Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Measured by its ability to inhibit secretion of IL-8 by A431 cells in the presence of IL-36?.
Less than 0.1 ng/µg of protein (less than 1EU/µg).
Sterile filtered, lyophilized from 10 mM sodium phosphate, pH 7.5
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
If lyophilized, can be stored for 1 month at room temperature, 6 months at 4°C, or through the expiration date at -20°C to -80°C. Once reconstituted per the supplied instructions, can be stored for 3 months at -20°C to -80°C, or for 1 week at 2°C to 8°C. Avoid repeat freeze-thaw cycles.
IL36RN Protein, FIL1 Protein, FIL1D Protein, IL-1 delta Protein, IL-1 related protein 3 Protein, IL-1HY1 Protein, IL-1RP3 Protein, IL-1-related protein 3 Protein, IL1F5 Protein, IL1RP3 Protein, IL1L1 Protein, IL36RA Protein, Interleukin-1 delta Protein, Family of interleukin 1-delta Protein, FIL1 delta Protein, IL-1L1 Protein, IL-1ra homolog 1 Protein, Interleukin-1 family member 5 Protein, Interleukin-1-like protein 1 Protein, FIL1(DELTA) Protein, IL-1F5 Protein, IL1HY1 Protein, Interleukin-1 HY1 Protein, PSORP Protein
Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation.