Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Measured by its ability to induce IL-8 production by human PBMCs.
Less than 0.1 ng/µg of protein (less than 1EU/µg).
Sterile filtered, lyophilized from 10 mM sodium phosphate, pH 7.0
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
If lyophilized, can be stored for 1 month at room temperature, 6 months at 4°C, or through the expiration date at -20°C to -80°C. Once reconstituted per the supplied instructions, can be stored for 3 months at -20°C to -80°C, or for 1 week at 2°C to 8°C. Avoid repeat freeze-thaw cycles.
IL36B Protein, FIL1 Protein, FIL1 eta Protein, FILI-(ETA) Protein, IL-1 eta Protein, IL-1F8 Protein, Interleukin 1, eta Protein, Interleukin-1 eta Protein, IL1F8 Protein, Interleukin 36, beta Protein, Interleukin-1 family member 8 Protein, Interleukin-1 Superfamily e Protein, Family of interleukin 1-eta Protein, FIL1H Protein, Interleukin-1 homolog 2 Protein, FIL1-(ETA) Protein, IL-1F8 (FIL1-eta) Protein, IL-1H2 Protein, IL1-ETA Protein, IL1H2 Protein, Interleukin-36 beta Protein
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP.