IL36B

interleukin 36, beta

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.

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Proteins (15)

Type

Over-Expression Lysate (2)

Recombinant (13)

Target

IL36B (15)

Publications

No (15)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (9)

Mouse (5)

Source

293T Cells (1)

E. coli (11)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (7)

Biologically Active

Biologically active (5)

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Human IL36B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71513

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.5 kDa

Price:

20 µg/$1,107

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Human IL36B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89968

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.5 kDa

Price:

20 µg/$150

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Human IL36B Protein (Recombinant GST) (Full Length) - LS-G33285

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

44.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse IL36B Protein (Recombinant) (Ser31-Lys183) - LS-G40082

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.6kD

Price:

10 µg/$288; 50 µg/$372; 500 µg/$1,585; 1 mg/$2,157

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IL36B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105365

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.5 kDa

Price:

100 µg/$494

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Mouse IL36B Protein (Recombinant) (Ser31-Lys183) - LS-G139001

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.6 kDa

Price:

10 µg/$269; 50 µg/$368

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Human IL36B Protein (Recombinant) - LS-G146010

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.2 kDa

Price:

10 µg/$345; 50 µg/$662

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Human IL36B Protein (Recombinant) - LS-G131441

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

~17.5 kDa

Price:

10 µg/$291; 100 µg/$490; 1 mg/$2,851

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Mouse IL36B Protein (Recombinant) (aa31-183) - LS-G3933

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Molecular Weight:

~17kDa

Price:

10 µg/$344

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Human IL36B Protein (Recombinant) (aa5-57) - LS-G3947

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 0.01 EU/µg protein (determined by LAL method).

Molecular Weight:

~15kDa (SDS-PAGE)

Price:

10 µg/$344

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Human IL36B Protein (Recombinant) (aa1-157) - LS-G5744

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

17.7kDa

Price:

10 µg/$388; 100 µg/$1,466; 500 µg/$3,025

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Human IL36B Protein (Recombinant) (aa5-157) - LS-G5746

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

17.2 kDa

Price:

10 µg/$388; 100 µg/$1,466; 500 µg/$3,025

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Mouse IL36B Protein (Recombinant) (aa1-183) - LS-G5850

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

20.9 kDa

Price:

10 µg/$388; 100 µg/$1,661; 500 µg/$3,629

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Mouse IL36B Protein (Recombinant) (aa31-183) - LS-G5852

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

17.4 kDa

Price:

10 µg/$388; 100 µg/$1,661; 500 µg/$3,629

Select

Human IL36B Protein (Recombinant) - LS-G185

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

17.3 kDa

Price:

2 µg/$268; 10 µg/$349

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