Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
HIF1A Protein, ARNT-interacting protein Protein, ARNT interacting protein Protein, BHLHe78 Protein, HIF1 Alpha Protein, Hypoxia-inducible factor1alpha Protein, HIF-1A Protein, HIF1 Protein, MOP1 Protein, Member of PAS superfamily 1 Protein, PASD8 Protein, HIF-1-alpha Protein, HIF-1alpha Protein, HIF1-ALPHA Protein, Member of PAS protein 1 Protein
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.