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HIF1A / HIF1 Alpha

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

Gene Name: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Synonyms: HIF1A, ARNT-interacting protein, ARNT interacting protein, BHLHe78, HIF1 Alpha, Hypoxia-inducible factor1alpha, HIF-1A, HIF1, MOP1, Member of PAS superfamily 1, PASD8, HIF-1-alpha, HIF-1alpha, HIF1-ALPHA, Member of PAS protein 1
Target Sequences: NM_001530 NP_001521.1 Q16665

Publications (464)

1
Aging persons' estimates of vehicular motion. Schiff W, Oldak R, Shah V. Psychology and aging. 1992 7:518-25. [PubMed:1466820]
2
[Interrelationships between methylmercury exposure and selenium supplementation in cockerels using selected laboratory diagnostic parameters and toxicological parameters of residues]. Wilsdorf G, Schulz O, Walzel R. DTW. Deutsche tierrztliche Wochenschrift. 1991 98:373-6. (WB; Mouse) [PubMed:1752206]
3
The sail sign. Chapman S. British journal of hospital medicine. 1991 46:399-400. (WB; Mouse) [PubMed:1760676]
4
Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Wiesener MS, Turley H, Allen WE, Willam C, Eckardt KU, Talks KL, Wood SM, Gatter KC, Harris AL, Pugh CW, Ratcliffe PJ, Maxwell PH. Blood. 1998 92:2260-8. [PubMed:9746763]
5
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW. Cancer research. 1999 59:5830-5. (IHC-P; Mouse, Human) [PubMed:10582706]
6
Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha. Gothi E, Richard DE, Berra E, Pags G, Pouyssgur J. The Journal of biological chemistry. 2000 275:6922-7. (WB; Human) [PubMed:10702253]
7
Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Sutter CH, Laughner E, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2000 97:4748-53. [PubMed:10758161] [PMC:PMC18304]
8
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. The American journal of pathology. 2000 157:411-21. (IHC, WB, IHC-P; Human) [PubMed:10934146] [PMC:PMC1850121]
9
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW. Proceedings of the National Academy of Sciences of the United States of America. 2000 97:10430-5. [PubMed:10973499] [PMC:PMC27041]
10
Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR. Annals of neurology. 2000 48:285-96. (WB; Human) [PubMed:10976634]
11
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G. Cancer research. 2000 60:4693-6. (IHC-P; Human) [PubMed:10987269]
12
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Koukourakis MI, Giatromanolaki A, Skarlatos J, Corti L, Blandamura S, Piazza M, Gatter KC, Harris AL. Cancer research. 2001 61:1830-2. (IHC-P; Human) [PubMed:11280732]
13
Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Birner P, Gatterbauer B, Oberhuber G, Schindl M, Rssler K, Prodinger A, Budka H, Hainfellner JA. Cancer. 2001 92:165-71. (IHC-P; Human) [PubMed:11443623]
14
Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells. Tacchini L, Dansi P, Matteucci E, Desiderio MA. Carcinogenesis. 2001 22:1363-71. [PubMed:11532856]
15
Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. Duyndam MC, Hulscher TM, Fontijn D, Pinedo HM, Boven E. The Journal of biological chemistry. 2001 276:48066-76. (WB; Human) [PubMed:11641398]
16
Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Giatromanolaki A, Koukourakis MI, Sivridis E, Pastorek J, Wykoff CC, Gatter KC, Harris AL. Cancer research. 2001 61:7992-8. (IHC-P; Human) [PubMed:11691824]
17
Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells. Tang T, Arbiser JL, Brandt SJ. The Journal of biological chemistry. 2002 277:18365-72. (WB; Human) [PubMed:11904294]
18
Effect of hypoxia on human seminoma cells. Fujii T, Otsuki T, Moriya T, Sakaguchi H, Kurebayashi J, Yata K, Uno M, Kobayashi T, Kimura T, Jo Y, Kinugawa K, Furukawa Y, Morioka M, Ueki A, Tanaka H. International journal of oncology. 2002 20:955-62. (ICC; Human) [PubMed:11956589]
19
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Beasley NJ, Leek R, Alam M, Turley H, Cox GJ, Gatter K, Millard P, Fuggle S, Harris AL. Cancer research. 2002 62:2493-7. (IHC-P; Human) [PubMed:11980639]
20
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP. Science (New York, N.Y.). 2002 296:1886-9. (IP) [PubMed:12004076]
21
Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer. Schindl M, Schoppmann SF, Samonigg H, Hausmaninger H, Kwasny W, Gnant M, Jakesz R, Kubista E, Birner P, Oberhuber G. Clinical cancer research : an official journal of the American Association for Cancer Research. 2002 8:1831-7. [PubMed:12060624]
22
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Mandriota SJ, Turner KJ, Davies DR, Murray PG, Morgan NV, Sowter HM, Wykoff CC, Maher ER, Harris AL, Ratcliffe PJ, Maxwell PH. Cancer cell. 2002 1:459-68. (IHC; Human) [PubMed:12124175]
23
Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression. Powell JD, Elshtein R, Forest DJ, Palladino MA. Biology of reproduction. 2002 67:995-1002. (WB; Rat) [PubMed:12193413]
24
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Ivan M, Haberberger T, Gervasi DC, Michelson KS, Gnzler V, Kondo K, Yang H, Sorokina I, Conaway RC, Conaway JW, Kaelin WG. Proceedings of the National Academy of Sciences of the United States of America. 2002 99:13459-64. [PubMed:12351678] [PMC:PMC129695]
25
Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells. Park JH, Kim TY, Jong HS, Kim TY, Chun YS, Park JW, Lee CT, Jung HC, Kim NK, Bang YJ. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 9:433-40. (WB; Human) [PubMed:12538497]
26
Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Burke B, Giannoudis A, Corke KP, Gill D, Wells M, Ziegler-Heitbrock L, Lewis CE. The American journal of pathology. 2003 163:1233-43. (IHC; Human) [PubMed:14507633] [PMC:PMC1868302]
27
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors. de Candia P, Solit DB, Giri D, Brogi E, Siegel PM, Olshen AB, Muller WJ, Rosen N, Benezra R. Proceedings of the National Academy of Sciences of the United States of America. 2003 100:12337-42. (IHC-P; Mouse) [PubMed:14526102] [PMC:PMC218759]
28
Hypoxic preconditioning of cardiomyocytes and cardioprotection: phophorylation of HIF-1alpha induced by p42/p44 mitogen-activated protein kinases is involved. Liu X, Wu X, Cai L, Tang C, Su J. Pathophysiology : the official journal of the International Society for Pathophysiology / ISP. 2003 9:201-205. (WB; Rat) [PubMed:14567922]
29
Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe?. Abbate A, Santini D, Biondi-Zoccai GG, Scarpa S, Vasaturo F, Liuzzo G, Bussani R, Silvestri F, Baldi F, Crea F, Biasucci LM, Baldi A. Heart (British Cardiac Society). 2004 90:440-3. (IHC-P; Human) [PubMed:15020525] [PMC:PMC1768143]
30
Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1alpha in non-small cell lung cancers. Hirami Y, Aoe M, Tsukuda K, Hara F, Otani Y, Koshimune R, Hanabata T, Nagahiro I, Sano Y, Date H, Shimizu N. Cancer letters. 2004 214:157-64. [PubMed:15363541]
31
c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Knies-Bamforth UE, Fox SB, Poulsom R, Evan GI, Harris AL. Cancer research. 2004 64:6563-70. (WB) [PubMed:15374969]
32
Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line. Aminova LR, Chavez JC, Lee J, Ryu H, Kung A, Lamanna JC, Ratan RR. The Journal of biological chemistry. 2005 280:3996-4003. (WB; Mouse) [PubMed:15557337]
33
Redox regulation of lung development and perinatal lung epithelial function. Land SC, Wilson SM. Antioxidants & redox signaling. 7:92-107. [PubMed:15650399]
34
Genistein inhibited retinal neovascularization and expression of vascular endothelial growth factor and hypoxia inducible factor 1alpha in a mouse model of oxygen-induced retinopathy. Wang B, Zou Y, Li H, Yan H, Pan JS, Yuan ZL. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2005 21:107-13. [PubMed:15857276]
35
Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells. Alberghini A, Recalcati S, Tacchini L, Santambrogio P, Campanella A, Cairo G. The Journal of biological chemistry. 2005 280:30120-8. (WB; Human) [PubMed:15985433]
36
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL. Cancer research. 2005 65:6178-88. [PubMed:16024619]
37
Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ. Blood. 2006 107:698-707. (WB; Mouse) [PubMed:16166593]
38
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Kong D, Park EJ, Stephen AG, Calvani M, Cardellina JH, Monks A, Fisher RJ, Shoemaker RH, Melillo G. Cancer research. 2005 65:9047-55. (GS; Human) [PubMed:16204079]
39
Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice. Wang J, Hoshijima M, Lam J, Zhou Z, Jokiel A, Dalton ND, Hultenby K, Ruiz-Lozano P, Ross J, Tryggvason K, Chien KR. The Journal of biological chemistry. 2006 281:213-20. [PubMed:16204254]
40
Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension. Rodriguez-Porcel M, Zhu XY, Chade AR, Amores-Arriaga B, Caplice NM, Ritman EL, Lerman A, Lerman LO. American journal of physiology. Heart and circulatory physiology. 2006 290:H978-84. [PubMed:16214846] [PMC:PMC1363360]
41
Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. Lu H, Dalgard CL, Mohyeldin A, McFate T, Tait AS, Verma A. The Journal of biological chemistry. 2005 280:41928-39. [PubMed:16223732]
42
Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Villanueva S, Cspedes C, Vio CP. American journal of physiology. Regulatory, integrative and comparative physiology. 2006 290:R861-70. [PubMed:16284088]
43
Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation. Quintero M, Brennan PA, Thomas GJ, Moncada S. Cancer research. 2006 66:770-4. [PubMed:16424008]
44
Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, Weindruch R. The Journal of nutrition. 2006 136:343-52. [PubMed:16424110]
45
Essential role of B-Raf in ERK activation during extraembryonic development. Galabova-Kovacs G, Matzen D, Piazzolla D, Meissl K, Plyushch T, Chen AP, Silva A, Baccarini M. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:1325-30. [PubMed:16432225] [PMC:PMC1360532]
46
Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1alpha variant for local induction of angiogenesis. Trentin D, Hall H, Wechsler S, Hubbell JA. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:2506-11. [PubMed:16477043] [PMC:PMC1413769]
47
Activation of hypoxia-inducible factor 1 during macrophage differentiation. Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, Arai T, Fukuda K, Kita T, Adachi T, Semenza GL, Nohara R. American journal of physiology. Cell physiology. 2006 291:C104-13. [PubMed:16481368]
48
Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility. Hsu T, Adereth Y, Kose N, Dammai V. The Journal of biological chemistry. 2006 281:12069-80. [PubMed:16505488] [PMC:PMC2367321]
49
A constitutively active hypoxia-inducible factor-1alpha/VP16 hybrid factor activates expression of the human B-type natriuretic peptide gene. Luo Y, Jiang C, Belanger AJ, Akita GY, Wadsworth SC, Gregory RJ, Vincent KA. Molecular pharmacology. 2006 69:1953-62. [PubMed:16507742]
50
Calcium signaling stimulates translation of HIF-alpha during hypoxia. Hui AS, Bauer AL, Striet JB, Schnell PO, Czyzyk-Krzeska MF. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 20:466-75. [PubMed:16507764]
51
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation. Lee KS, Kim SR, Park SJ, Lee HK, Park HS, Min KH, Jin SM, Lee YC. Molecular pharmacology. 2006 69:1829-39. (WB; Mouse) [PubMed:16527906]
52
EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Pore N, Jiang Z, Gupta A, Cerniglia G, Kao GD, Maity A. Cancer research. 2006 66:3197-204. [PubMed:16540671]
53
Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha. Fath DM, Kong X, Liang D, Lin Z, Chou A, Jiang Y, Fang J, Caro J, Sang N. The Journal of biological chemistry. 2006 281:13612-9. [PubMed:16543236] [PMC:PMC1564196]
54
Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia. Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung AM, Brown AS, Hicklin DJ, Foster FS, Kerbel RS. Cancer research. 2006 66:3639-48. [PubMed:16585189]
55
Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia. Zampino M, Yuzhakova M, Hansen J, McKinney RD, Goldspink PH, Geenen DL, Buttrick PM. American journal of physiology. Heart and circulatory physiology. 2006 291:H957-64. [PubMed:16603692]
56
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC. Molecular and cellular biology. 2006 26:3514-26. [PubMed:16611993] [PMC:PMC1447431]
57
Bone marrow-derived cells home to and regenerate retinal pigment epithelium after injury. Harris JR, Brown GA, Jorgensen M, Kaushal S, Ellis EA, Grant MB, Scott EW. Investigative ophthalmology & visual science. 2006 47:2108-13. (IHC-P; Mouse) [PubMed:16639022]
58
Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. Wang R, Zhang YW, Zhang X, Liu R, Zhang X, Hong S, Xia K, Xia J, Zhang Z, Xu H. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 20:1275-7. [PubMed:16645044]
59
Oxygen concentration is an important factor for modulating progesterone synthesis in bovine corpus luteum. Nishimura R, Sakumoto R, Tatsukawa Y, Acosta TJ, Okuda K. Endocrinology. 2006 147:4273-80. [PubMed:16740971]
60
Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. Bracken CP, Fedele AO, Linke S, Balrak W, Lisy K, Whitelaw ML, Peet DJ. The Journal of biological chemistry. 2006 281:22575-85. (WB; Human) [PubMed:16760477]
61
Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. Bernhardt WM, Cmpean V, Kany S, Jrgensen JS, Weidemann A, Warnecke C, Arend M, Klaus S, Gnzler V, Amann K, Willam C, Wiesener MS, Eckardt KU. Journal of the American Society of Nephrology : JASN. 2006 17:1970-8. (IHC-P; Rat) [PubMed:16762988]
62
Synergistic effects of CoCl(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells. Pacary E, Legros H, Valable S, Duchatelle P, Lecocq M, Petit E, Nicole O, Bernaudin M. Journal of cell science. 2006 119:2667-78. [PubMed:16772336]
63
5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J, Foretz M, Viollet B. Molecular and cellular biology. 2006 26:5336-47. [PubMed:16809770] [PMC:PMC1592699]
64
Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. McMahon S, Charbonneau M, Grandmont S, Richard DE, Dubois CM. The Journal of biological chemistry. 2006 281:24171-81. (WB; Human) [PubMed:16815840]
65
bFGF induces an earlier expression of nephrogenic proteins after ischemic acute renal failure. Villanueva S, Cespedes C, Gonzalez A, Vio CP. American journal of physiology. Regulatory, integrative and comparative physiology. 2006 291:R1677-87. [PubMed:16873559]
66
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. Grimmer C, Balbus N, Lang U, Aigner T, Cramer T, Mller L, Swoboda B, Pfander D. The American journal of pathology. 2006 169:491-502. [PubMed:16877351] [PMC:PMC1698781]
67
Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells. Brooks C, Wang J, Yang T, Dong Z. American journal of physiology. Renal physiology. 2007 292:F243-52. (WB; Human) [PubMed:16885151]
68
Estrogen induces angiogenesis of the female rabbit bladder. Lin AD, Mannikarottu A, Kogan BA, Whitbeck C, Chichester P, Leggett RE, Levin RM. The Journal of endocrinology. 2006 190:241-6. (WB; Rabbit) [PubMed:16899558]
69
Hypoxia and expression of hypoxia-inducible factor in the aging kidney. Tanaka T, Kato H, Kojima I, Ohse T, Son D, Tawakami T, Yatagawa T, Inagi R, Fujita T, Nangaku M. The journals of gerontology. Series A, Biological sciences and medical sciences. 2006 61:795-805. [PubMed:16912095]
70
Differentiation arrest by hypoxia. Lin Q, Lee YJ, Yun Z. The Journal of biological chemistry. 2006 281:30678-83. (WB; Mouse) [PubMed:16926163]
71
Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response. Hwang II, Watson IR, Der SD, Ohh M. Journal of virology. 2006 80:10712-23. [PubMed:16928739] [PMC:PMC1641802]
72
Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice. Shen F, Su H, Fan Y, Chen Y, Zhu Y, Liu W, Young WL, Yang GY. Stroke; a journal of cerebral circulation. 2006 37:2601-6. [PubMed:16946160]
73
Overexpression of hypoxia-inducible factor 1alpha and p53 is a marker for an unfavorable prognosis in gastric cancer. Sumiyoshi Y, Kakeji Y, Egashira A, Mizokami K, Orita H, Maehara Y. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 12:5112-7. [PubMed:16951228]
74
Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. An HJ, Maeng O, Kang KH, Lee JO, Kim YS, Paik SG, Lee H. The Journal of biological chemistry. 2006 281:33939-48. [PubMed:16954213]
75
Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. Carroll PA, Kenerson HL, Yeung RS, Lagunoff M. Journal of virology. 2006 80:10802-12. (IHC-P; Human) [PubMed:16956952] [PMC:PMC1641760]
76
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. Chavez JC, Baranova O, Lin J, Pichiule P. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 26:9471-81. [PubMed:16971531]
77
Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats. McLaren AT, Marsden PA, Mazer CD, Baker AJ, Stewart DJ, Tsui AK, Li X, Yucel Y, Robb M, Boyd SR, Liu E, Yu J, Hare GM. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 292:R403-14. (ICC, IHC, WB, IHC-P; Rat) [PubMed:16973934]
78
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Chen H, Yan Y, Davidson TL, Shinkai Y, Costa M. Cancer research. 2006 66:9009-16. [PubMed:16982742]
79
Regulation of the ring finger E3 ligase Siah2 by p38 MAPK. Khurana A, Nakayama K, Williams S, Davis RJ, Mustelin T, Ronai Z. The Journal of biological chemistry. 2006 281:35316-26. [PubMed:17003045] [PMC:PMC2954258]
80
Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Khan Z, Michalopoulos GK, Stolz DB. The American journal of pathology. 2006 169:1251-69. (ICC, IHC-P; Rat) [PubMed:17003483] [PMC:PMC1698853]
81
Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, Wenger RH, Ohta A, Sitkovsky M. Journal of immunology (Baltimore, Md. : 1950). 2006 177:4962-5. (WB; Mouse) [PubMed:17015677]
82
Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter. Ramanathan M, Pinhal-Enfield G, Hao I, Leibovich SJ. Molecular biology of the cell. 2007 18:14-23. (WB; Mouse) [PubMed:17065555] [PMC:PMC1751314]
83
Hypoxic regulation of Id-1 and activation of the unfolded protein response are aberrant in neuroblastoma. Nemetski SM, Gardner LB. The Journal of biological chemistry. 2007 282:240-8. (WB; Mouse) [PubMed:17102133]
84
HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells. Pore N, Gupta AK, Cerniglia GJ, Maity A. Neoplasia (New York, N.Y.). 2006 8:889-95. (WB; Human) [PubMed:17132220] [PMC:PMC1716015]
85
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Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221. Creighton-Gutteridge M, Cardellina JH, Stephen AG, Rapisarda A, Uranchimeg B, Hite K, Denny WA, Shoemaker RH, Melillo G. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 13:1010-8. [PubMed:17289897]
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Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. Zhang X, Zhou K, Wang R, Cui J, Lipton SA, Liao FF, Xu H, Zhang YW. The Journal of biological chemistry. 2007 282:10873-80. [PubMed:17303576]
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Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Bernhardt WM, Wiesener MS, Weidemann A, Schmitt R, Weichert W, Lechler P, Campean V, Ong AC, Willam C, Gretz N, Eckardt KU. The American journal of pathology. 2007 170:830-42. (IHC-P; Rat) [PubMed:17322369] [PMC:PMC1864863]
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Hypoxia inducible factor regulates the cardiac expression and secretion of apelin. Ronkainen VP, Ronkainen JJ, Hnninen SL, Leskinen H, Ruas JL, Pereira T, Poellinger L, Vuolteenaho O, Tavi P. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2007 21:1821-30. [PubMed:17341685]
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Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model. Jayle C, Favreau F, Zhang K, Doucet C, Goujon JM, Hebrard W, Carretier M, Eugene M, Mauco G, Tillement JP, Hauet T. American journal of physiology. Renal physiology. 2007 292:F1082-93. [PubMed:17341718]
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Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, Ohneda O, Takeda N, Sata M, Miyata T, Fujita T, Nangaku M. Journal of the American Society of Nephrology : JASN. 2007 18:1218-26. [PubMed:17344427]
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Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning. Chin BY, Jiang G, Wegiel B, Wang HJ, Macdonald T, Zhang XC, Gallo D, Cszimadia E, Bach FH, Lee PJ, Otterbein LE. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:5109-14. [PubMed:17360382] [PMC:PMC1820823]
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Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway. Jeong CH, Lee HJ, Cha JH, Kim JH, Kim KR, Kim JH, Yoon DK, Kim KW. The Journal of biological chemistry. 2007 282:13672-9. [PubMed:17360716]
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Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. Lang SA, Klein D, Moser C, Gaumann A, Glockzin G, Dahlke MH, Dietmaier W, Bolder U, Schlitt HJ, Geissler EK, Stoeltzing O. Molecular cancer therapeutics. 2007 6:1123-32. (WB; Human) [PubMed:17363505]
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Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy. Shimojo N, Jesmin S, Zaedi S, Otsuki T, Maeda S, Yamaguchi N, Aonuma K, Hattori Y, Miyauchi T. American journal of physiology. Heart and circulatory physiology. 2007 293:H474-81. [PubMed:17369464]
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Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia. Bateman RM, Tokunaga C, Kareco T, Dorscheid DR, Walley KR. American journal of physiology. Heart and circulatory physiology. 2007 293:H448-56. (WB; Rat) [PubMed:17369472]
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Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo. Gillespie DL, Whang K, Ragel BT, Flynn JR, Kelly DA, Jensen RL. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 13:2441-8. [PubMed:17438103]
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Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements. Young HW, Williams OW, Chandra D, Bellinghausen LK, Prez G, Surez A, Tuvim MJ, Roy MG, Alexander SN, Moghaddam SJ, Adachi R, Blackburn MR, Dickey BF, Evans CM. American journal of respiratory cell and molecular biology. 2007 37:273-90. (ChrIP; Human) [PubMed:17463395] [PMC:PMC1994232]
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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL. Cancer cell. 2007 11:407-20. [PubMed:17482131]
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Over-expression of hypoxia-inducible factor 1 alpha in ovarian clear cell carcinoma. Lee S, Garner EI, Welch WR, Berkowitz RS, Mok SC. Gynecologic oncology. 2007 106:311-7. [PubMed:17532031] [PMC:PMC1995602]
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The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling. Ide T, Kitajima Y, Miyoshi A, Ohtsuka T, Mitsuno M, Ohtaka K, Miyazaki K. Annals of surgical oncology. 2007 14:2600-7. [PubMed:17534684]
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Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL. The Journal of biological chemistry. 2007 282:23572-80. [PubMed:17558023]
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Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Monsef N, Helczynski L, Lundwall A, Phlman S. The Prostate. 2007 67:1219-29. [PubMed:17562539]
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Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms. Hunt TK, Aslam RS, Beckert S, Wagner S, Ghani QP, Hussain MZ, Roy S, Sen CK. Antioxidants & redox signaling. 2007 9:1115-24. [PubMed:17567242] [PMC:PMC2443402]
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BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Tracy K, Dibling BC, Spike BT, Knabb JR, Schumacker P, Macleod KF. Molecular and cellular biology. 2007 27:6229-42. [PubMed:17576813] [PMC:PMC1952167]
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Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. Molecular and cellular biology. 2007 27:7381-93. (ChrIP; Human) [PubMed:17785433] [PMC:PMC2169056]
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Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer. Yamamoto Y, Ibusuki M, Okumura Y, Kawasoe T, Kai K, Iyama K, Iwase H. Breast cancer research and treatment. 2008 110:465-75. [PubMed:17805961]
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Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells. Cheng G, Shao Z, Chaudhari B, Agrawal DK. American journal of physiology. Lung cellular and molecular physiology. 2007 293:L1339-47. [PubMed:17873007]
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Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. Baek JH, Liu YV, McDonald KR, Wesley JB, Zhang H, Semenza GL. The Journal of biological chemistry. 2007 282:33358-66. [PubMed:17875644]
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Differential regulation of hypoxia-induced CXCR4 triggering during B-cell development and lymphomagenesis. Piovan E, Tosello V, Indraccolo S, Masiero M, Persano L, Esposito G, Zamarchi R, Ponzoni M, Chieco-Bianchi L, Dalla-Favera R, Amadori A. Cancer research. 2007 67:8605-14. (IHC-P, IHC-Fr; Human) [PubMed:17875700]
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Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation. Black SM, DeVol JM, Wedgwood S. American journal of physiology. Cell physiology. 2008 294:C345-54. [PubMed:17942638]
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Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. Liu YV, Hubbi ME, Pan F, McDonald KR, Mansharamani M, Cole RN, Liu JO, Semenza GL. The Journal of biological chemistry. 2007 282:37064-73. [PubMed:17965024]
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Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model. Ohtomo S, Nangaku M, Izuhara Y, Takizawa S, Strihou Cv, Miyata T. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 23:1166-72. (IHC, WB; Rat) [PubMed:17967803]
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High-fat, high-sucrose, and high-cholesterol diets accelerate tumor growth and metastasis in tumor-bearing mice. Kimura Y, Sumiyoshi M. Nutrition and cancer. 2007 59:207-16. (IHC, WB; Mouse) [PubMed:18001216]
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Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia. Ryu J, Lee CW, Hong KH, Shin JA, Lim SH, Park CS, Shim J, Nam KB, Choi KJ, Kim YH, Han KH. Cardiovascular research. 2008 78:333-40. [PubMed:18006432]
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The neurohormone orexin stimulates hypoxia-inducible factor-1 activity. Sikder D, Kodadek T. Genes & development. 2007 21:2995-3005. (WB; Human) [PubMed:18006690] [PMC:PMC2049199]
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Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, Saito Y, Johnson RS, Kretzler M, Cohen CD, Eckardt KU, Iwano M, Haase VH. The Journal of clinical investigation. 2007 117:3810-20. [PubMed:18037992] [PMC:PMC2082142]
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Evidence for sustained renal hypoxia and transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury. Rosenberger C, Goldfarb M, Shina A, Bachmann S, Frei U, Eckardt KU, Schrader T, Rosen S, Heyman SN. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 23:1135-43. [PubMed:18048419]
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Glomerular endothelium in kidneys with congenital nephrotic syndrome of the Finnish type (NPHS1). Kaukinen A, Kuusniemi AM, Lautenschlager I, Jalanko H. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 23:1224-32. [PubMed:18048423]
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Acute hypobaric hypoxia (5486 m) induces greater pulmonary HIF-1 activation in hilltop compared to madison rats. Engebretsen BJ, Irwin D, Valdez ME, O'Donovan MK, Tucker A, van Patot MT. High altitude medicine & biology. 2007 8:312-21. [PubMed:18081507]
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Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. Klatte T, Seligson DB, Riggs SB, Leppert JT, Berkman MK, Kleid MD, Yu H, Kabbinavar FF, Pantuck AJ, Belldegrun AS. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 13:7388-93. [PubMed:18094421]
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Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG. Blood. 2008 111:3236-44. (WB; Mouse) [PubMed:18096761] [PMC:PMC2265460]
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Inhibition of bFGF-receptor type 2 increases kidney damage and suppresses nephrogenic protein expression after ischemic acute renal failure. Villanueva S, Cespedes C, Gonzalez AA, Roessler E, Vio CP. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 294:R819-28. [PubMed:18184769]
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Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells. Piantadosi CA, Suliman HB. The Journal of biological chemistry. 2008 283:10967-77. (ICC, WB, IP; Human) [PubMed:18252725] [PMC:PMC2447662]
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HIF activation protects from acute kidney injury. Weidemann A, Bernhardt WM, Klanke B, Daniel C, Buchholz B, Cmpean V, Amann K, Warnecke C, Wiesener MS, Eckardt KU, Willam C. Journal of the American Society of Nephrology : JASN. 2008 19:486-94. (IHC) [PubMed:18256363] [PMC:PMC2391048]
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Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. The Journal of biological chemistry. 2008 283:10892-903. (WB; Mouse, Human) [PubMed:18281291] [PMC:PMC2447655]
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HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus. Nagao K, Taniyama Y, Kietzmann T, Doi T, Komuro I, Morishita R. The Journal of biological chemistry. 2008 283:11841-9. [PubMed:18303027]
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Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours. Kubo T, Sugita T, Shimose S, Matsuo T, Arihiro K, Ochi M. The Journal of bone and joint surgery. British volume. 2008 90:364-70. (WB, IHC-P; Human) [PubMed:18310762]
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Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. Hartmann H, Eltzschig HK, Wurz H, Hantke K, Rakin A, Yazdi AS, Matteoli G, Bohn E, Autenrieth IB, Karhausen J, Neumann D, Colgan SP, Kempf VA. Gastroenterology. 2008 134:756-67. [PubMed:18325389]
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Metallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1alpha. Murphy BJ, Kimura T, Sato BG, Shi Y, Andrews GK. Molecular cancer research : MCR. 2008 6:483-90. [PubMed:18337454]
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Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis. Singh RP, Gu M, Agarwal R. Cancer research. 2008 68:2043-50. (IHC-P; Human) [PubMed:18339887]
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A possible role for hypoxia-induced apelin expression in enteric cell proliferation. Han S, Wang G, Qi X, Lee HM, Englander EW, Greeley GH. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 294:R1832-9. [PubMed:18367654]
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(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors. Lauzier MC, Robitaille GA, Chan DA, Giaccia AJ, Richard DE. Molecular pharmacology. 2008 74:282-8. (WB; Human) [PubMed:18424552] [PMC:PMC3050611]
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The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells. Yamashita T, Ohneda O, Sakiyama A, Iwata F, Ohneda K, Fujii-Kuriyama Y. Blood. 2008 112:1482-92. [PubMed:18451309]
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Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells. Radek KA, Kovacs EJ, Gallo RL, DiPietro LA. American journal of physiology. Heart and circulatory physiology. 2008 295:H174-84. [PubMed:18469146] [PMC:PMC2494747]
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Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia. Frew IJ, Minola A, Georgiev S, Hitz M, Moch H, Richard S, Vortmeyer AO, Krek W. Molecular and cellular biology. 2008 28:4536-48. [PubMed:18474617] [PMC:PMC2447121]
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Hypoxia-stimulated vascular endothelial growth factor production in human nasal polyp fibroblasts: effect of epigallocatechin-3-gallate on hypoxia-inducible factor-1 alpha synthesis. Lin SK, Shun CT, Kok SH, Wang CC, Hsiao TY, Liu CM. Archives of otolaryngology--head & neck surgery. 2008 134:522-7. [PubMed:18490575]
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Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. Rosenberger C, Rosen S, Shina A, Frei U, Eckardt KU, Flippin LA, Arend M, Klaus SJ, Heyman SN. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 23:3472-8. [PubMed:18515655]
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Population origin, development and temperature of development affect the amounts of HSP70, HSP90 and the putative hypoxia-inducible factor in the tadpoles of the common frog Rana temporaria. Nikinmaa M, Leveelahti L, Dahl E, Rissanen E, Rytknen KT, Laurila A. The Journal of experimental biology. 2008 211:1999-2004. (WB; Xenopus) [PubMed:18515731]
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Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals. Tacchini L, Gammella E, De Ponti C, Recalcati S, Cairo G. The Journal of biological chemistry. 2008 283:20674-86. [PubMed:18519569] [PMC:PMC3258948]
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Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling. Champion KJ, Guinea M, Dammai V, Hsu T. Cancer research. 2008 68:4649-57. [PubMed:18559510] [PMC:PMC2650247]
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High oxygen prevents fetal lethality due to lack of catecholamines. Ream MA, Chandra R, Peavey M, Ray AM, Roffler-Tarlov S, Kim HG, Wetsel WC, Rockman HA, Chikaraishi DM. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 295:R942-53. (WB; Mouse) [PubMed:18635452] [PMC:PMC2536863]
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ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo. Moser C, Lang SA, Mori A, Hellerbrand C, Schlitt HJ, Geissler EK, Fogler WE, Stoeltzing O. BMC cancer. 2008 8:206. [PubMed:18651980] [PMC:PMC2496914]
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Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Kimura K, Iwano M, Higgins DF, Yamaguchi Y, Nakatani K, Harada K, Kubo A, Akai Y, Rankin EB, Neilson EG, Haase VH, Saito Y. American journal of physiology. Renal physiology. 2008 295:F1023-9. [PubMed:18667485]
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Divergent effects of hypoxia on dendritic cell functions. Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A. Blood. 2008 112:3723-34. [PubMed:18694997]
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Adventitial transplantation of blood outgrowth endothelial cells in porcine haemodialysis grafts alleviates hypoxia and decreases neointimal proliferation through a matrix metalloproteinase-9-mediated pathway--a pilot study. Hughes D, Fu AA, Puggioni A, Glockner JF, Anwer B, McGuire AM, Mukhopadhyay D, Misra S. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009 24:85-96. [PubMed:18786975] [PMC:PMC2639314]
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Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation. Hlushchuk R, Riesterer O, Baum O, Wood J, Gruber G, Pruschy M, Djonov V. The American journal of pathology. 2008 173:1173-85. [PubMed:18787105] [PMC:PMC2543084]
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HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice. Saini Y, Harkema JR, LaPres JJ. The Journal of biological chemistry. 2008 283:33650-7. (WB; Mouse) [PubMed:18801745] [PMC:PMC2586263]
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Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells. Westfall SD, Sachdev S, Das P, Hearne LB, Hannink M, Roberts RM, Ezashi T. Stem cells and development. 2008 17:869-81. (ICC; Human) [PubMed:18811242] [PMC:PMC3189708]
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p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury. Sutton TA, Wilkinson J, Mang HE, Knipe NL, Plotkin Z, Hosein M, Zak K, Wittenborn J, Dagher PC. American journal of physiology. Renal physiology. 2008 295:F1666-77. (IHC-P; Rat) [PubMed:18815219] [PMC:PMC2604829]
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A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells. Meyuhas R, Pikarsky E, Tavor E, Klar A, Abramovitch R, Hochman J, Lago TG, Honigman A. Molecular cancer research : MCR. 2008 6:1397-409. (WB; Mouse) [PubMed:18819928]
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Placental HIFs as markers of cerebral hypoxic distress in fetal mice. Trollmann R, Strasser K, Keller S, Antoniou X, Grenacher B, Ogunshola OO, Dtsch J, Rascher W, Gassmann M. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 295:R1973-81. (IHC, WB; Mouse) [PubMed:18832080]
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PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress. Yang G, Sun Q, Teng Y, Li F, Weng T, Yang X. Development (Cambridge, England). 2008 135:3587-97. [PubMed:18832389]
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Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response. Stagg J, Sharkey J, Pommey S, Young R, Takeda K, Yagita H, Johnstone RW, Smyth MJ. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:16254-9. [PubMed:18838682] [PMC:PMC2570981]
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Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts. Wirthner R, Wrann S, Balamurugan K, Wenger RH, Stiehl DP. Carcinogenesis. 2008 29:2306-16. (WB; Mouse) [PubMed:18842680]
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Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-. Alam H, Weck J, Maizels E, Park Y, Lee EJ, Ashcroft M, Hunzicker-Dunn M. Endocrinology. 2009 150:915-28. [PubMed:18845636] [PMC:PMC2646536]
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Inhibition of HIF-1alpha by the anticancer drug TAS106 enhances X-ray-induced apoptosis in vitro and in vivo. Yasui H, Ogura A, Asanuma T, Matsuda A, Kashiwakura I, Kuwabara M, Inanami O. British journal of cancer. 2008 99:1442-52. [PubMed:18854835] [PMC:PMC2579694]
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Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity. Lysiak JJ, Kirby JL, Tremblay JJ, Woodson RI, Reardon MA, Palmer LA, Turner TT. Journal of andrology. 30:146-56. [PubMed:18930903]
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Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy. Shibata R, Ueda S, Yamagishi S, Kaida Y, Matsumoto Y, Fukami K, Hayashida A, Matsuoka H, Kato S, Kimoto M, Okuda S. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009 24:1162-9. [PubMed:19015171]
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Molecular angiogenic signaling in angiofibromas after embolization: implications for therapy. Ngan BY, Forte V, Campisi P. Archives of otolaryngology--head & neck surgery. 2008 134:1170-6. [PubMed:19015446]
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Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice. Botusan IR, Sunkari VG, Savu O, Catrina AI, Grnler J, Lindberg S, Pereira T, Yl-Herttuala S, Poellinger L, Brismar K, Catrina SB. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:19426-31. (IHC, WB; Mouse) [PubMed:19057015] [PMC:PMC2614777]
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Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression. Gilbert JS, Gilbert SA, Arany M, Granger JP. Hypertension. 2009 53:399-403. [PubMed:19075097] [PMC:PMC2692089]
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Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing. Keely S, Glover LE, MacManus CF, Campbell EL, Scully MM, Furuta GT, Colgan SP. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009 23:1338-46. [PubMed:19103643] [PMC:PMC2669428]
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mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha. Wong W, Goehring AS, Kapiloff MS, Langeberg LK, Scott JD. Science signaling. 2008 1:ra18. [PubMed:19109240] [PMC:PMC2828263]
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Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia. El Hasnaoui-Saadani R, Pichon A, Marchant D, Olivier P, Launay T, Quidu P, Beaudry M, Duvallet A, Richalet JP, Favret F. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 296:R801-11. [PubMed:19109375]
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Hypoxia-inducible factor-1alpha protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression. Yeh SH, Hung JJ, Gean PW, Chang WC. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 28:14259-70. [PubMed:19109507]
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Adaptive response of the heart to long-term anemia induced by iron deficiency. Naito Y, Tsujino T, Matsumoto M, Sakoda T, Ohyanagi M, Masuyama T. American journal of physiology. Heart and circulatory physiology. 2009 296:H585-93. (WB; Rat) [PubMed:19136608]
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Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Tyagi A, Singh RP, Ramasamy K, Raina K, Redente EF, Dwyer-Nield LD, Radcliffe RA, Malkinson AM, Agarwal R. Cancer prevention research (Philadelphia, Pa.). 2009 2:74-83. [PubMed:19139021] [PMC:PMC2615181]
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Hypoxia stimulates via separate pathways ERK phosphorylation and NF-kappaB activation in skeletal muscle cells in primary culture. Osorio-Fuentealba C, Valds JA, Riquelme D, Hidalgo J, Hidalgo C, Carrasco MA. Journal of applied physiology (Bethesda, Md. : 1985). 2009 106:1301-10. [PubMed:19179647]
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Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neur. Lomb DJ, Desouza LA, Franklin JL, Freeman RS. Molecular pharmacology. 2009 75:1198-209. (WB; Mouse) [PubMed:19204094] [PMC:PMC2672811]
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Cytogenetic and molecular tumor profiling for type 1 and type 2 papillary renal cell carcinoma. Klatte T, Pantuck AJ, Said JW, Seligson DB, Rao NP, LaRochelle JC, Shuch B, Zisman A, Kabbinavar FF, Belldegrun AS. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:1162-9. [PubMed:19228721]
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Antitumor activity of an oncolytic adenoviral-CD40 ligand (CD154) transgene construct in human breast cancer cells. Gomes EM, Rodrigues MS, Phadke AP, Butcher LD, Starling C, Chen S, Chang D, Hernandez-Alcoceba R, Newman JT, Stone MJ, Tong AW. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:1317-25. (IHC; Human) [PubMed:19228733]
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Molecular signatures of localized clear cell renal cell carcinoma to predict disease-free survival after nephrectomy. Klatte T, Seligson DB, LaRochelle J, Shuch B, Said JW, Riggs SB, Zomorodian N, Kabbinavar FF, Pantuck AJ, Belldegrun AS. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2009 18:894-900. [PubMed:19240241]
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Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M. Circulation research. 2009 104:879-86. (ICC; Rat) [PubMed:19265035] [PMC:PMC3332328]
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GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. Amann T, Maegdefrau U, Hartmann A, Agaimy A, Marienhagen J, Weiss TS, Stoeltzing O, Warnecke C, Schlmerich J, Oefner PJ, Kreutz M, Bosserhoff AK, Hellerbrand C. The American journal of pathology. 2009 174:1544-52. [PubMed:19286567] [PMC:PMC2671384]
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The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. Kimbrel EA, Kung AL. The Journal of biological chemistry. 2009 284:13033-44. [PubMed:19297328] [PMC:PMC2676036]
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Hypoxia inducible factor-1alpha correlates with vascular endothelial growth factor A and C indicating worse prognosis in clear cell renal cell carcinoma. Dorevi G, Matusan-Ilijas K, Babarovi E, Hadzisejdi I, Grahovac M, Grahovac B, Jonji N. Journal of experimental & clinical cancer research : CR. 2009 28:40. (IHC-P; Human) [PubMed:19302703] [PMC:PMC2664792]
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Signaling by hypoxia-inducible factors is critical for ovulation in mice. Kim J, Bagchi IC, Bagchi MK. Endocrinology. 2009 150:3392-400. [PubMed:19325003] [PMC:PMC2703551]
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Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE. Blood. 2009 113:5568-74. [PubMed:19336759] [PMC:PMC2689054]
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ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells. Hatipoglu OF, Hirohata S, Cilek MZ, Ogawa H, Miyoshi T, Obika M, Demircan K, Shinohata R, Kusachi S, Ninomiya Y. The Journal of biological chemistry. 2009 284:16325-33. [PubMed:19349275] [PMC:PMC2713541]
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An anti-vascular endothelial growth factor receptor 2/fetal liver kinase-1 Listeria monocytogenes anti-angiogenesis cancer vaccine for the treatment of primary and metastatic Her-2/neu+ breast tumors in a mouse model. Seavey MM, Maciag PC, Al-Rawi N, Sewell D, Paterson Y. Journal of immunology (Baltimore, Md. : 1950). 2009 182:5537-46. (ICC, IHC; Mouse) [PubMed:19380802] [PMC:PMC2850569]
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Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible factor pathway. Rhoads RP, Johnson RM, Rathbone CR, Liu X, Temm-Grove C, Sheehan SM, Hoying JB, Allen RE. American journal of physiology. Cell physiology. 2009 296:C1321-8. [PubMed:19386789] [PMC:PMC2692418]
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Hypoxia-inducible factor (HIF) 1alpha accumulation and HIF target gene expression are impaired after induction of endotoxin tolerance. Frede S, Stockmann C, Winning S, Freitag P, Fandrey J. Journal of immunology (Baltimore, Md. : 1950). 2009 182:6470-6. (WB; Human) [PubMed:19414801]
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Magnesium deficiency causes loss of response to intermittent hypoxia in paraganglion cells. Torii S, Kobayashi K, Takahashi M, Katahira K, Goryo K, Matsushita N, Yasumoto K, Fujii-Kuriyama Y, Sogawa K. The Journal of biological chemistry. 2009 284:19077-89. [PubMed:19433582] [PMC:PMC2707206]
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Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:8760-5. [PubMed:19433784] [PMC:PMC2688966]
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Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E, Greten FR, Rius J, Lewis CE. Blood. 2009 114:844-59. [PubMed:19454749] [PMC:PMC2882173]
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Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium. Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, Haldar SM, Maemura K, Lamanna JC, Jain MK. The Journal of biological chemistry. 2009 284:20522-30. [PubMed:19491109] [PMC:PMC2742816]
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An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Benita Y, Kikuchi H, Smith AD, Zhang MQ, Chung DC, Xavier RJ. Nucleic acids research. 2009 37:4587-602. [PubMed:19491311] [PMC:PMC2724271]
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Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs. Hansen SL, Trakooljul N, Liu HC, Moeser AJ, Spears JW. The Journal of nutrition. 2009 139:1474-9. [PubMed:19535423]
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mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Shackelford DB, Vasquez DS, Corbeil J, Wu S, Leblanc M, Wu CL, Vera DR, Shaw RJ. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:11137-42. [PubMed:19541609] [PMC:PMC2708689]
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Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization. Loinard C, Ginouvs A, Vilar J, Cochain C, Zouggari Y, Recalde A, Duriez M, Lvy BI, Pouyssgur J, Berra E, Silvestre JS. Circulation. 2009 120:50-9. (WB; Mouse, Human) [PubMed:19546390]
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MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. Aubert S, Fauquette V, Hmon B, Lepoivre R, Briez N, Bernard D, Van Seuningen I, Leroy X, Perrais M. Cancer research. 2009 69:5707-15. [PubMed:19549898]
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Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3. Hsu K, Chi N, Gucek M, Van Eyk JE, Cole RN, Lin M, Foster DB. Blood. 2009 114:1919-28. [PubMed:19564639] [PMC:PMC2738576]
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mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition. Bhaskar PT, Nogueira V, Patra KC, Jeon SM, Park Y, Robey RB, Hay N. Molecular and cellular biology. 2009 29:5136-47. [PubMed:19620286] [PMC:PMC2738274]
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Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response. Doroudgar S, Thuerauf DJ, Marcinko MC, Belmont PJ, Glembotski CC. The Journal of biological chemistry. 2009 284:29735-45. [PubMed:19622751] [PMC:PMC2785605]
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Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. Inagaki T, Tachibana M, Magoori K, Kudo H, Tanaka T, Okamura M, Naito M, Kodama T, Shinkai Y, Sakai J. Genes to cells : devoted to molecular & cellular mechanisms. 2009 14:991-1001. (WB; Mouse) [PubMed:19624751]
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TSC2 deficiency increases PTEN via HIF1alpha. Mahimainathan L, Ghosh-Choudhury N, Venkatesan B, Das F, Mandal CC, Dey N, Habib SL, Kasinath BS, Abboud HE, Ghosh Choudhury G. The Journal of biological chemistry. 2009 284:27790-8. [PubMed:19648120] [PMC:PMC2788829]
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Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell MJ, Bissell M, Boudreau N. Cancer research. 2009 69:6721-9. [PubMed:19654314] [PMC:PMC2760003]
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The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues. Thangarajah H, Yao D, Chang EI, Shi Y, Jazayeri L, Vial IN, Galiano RD, Du XL, Grogan R, Galvez MG, Januszyk M, Brownlee M, Gurtner GC. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:13505-10. [PubMed:19666581] [PMC:PMC2726398]
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Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. Lee DW, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal MF, Ratan RR, Andersen JK. The Journal of biological chemistry. 2009 284:29065-76. [PubMed:19679656] [PMC:PMC2781452]
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Pharmacological stimulation of soluble guanylate cyclase modulates hypoxia-inducible factor-1alpha in rat heart. Tsuruda T, Hatakeyama K, Masuyama H, Sekita Y, Imamura T, Asada Y, Kitamura K. American journal of physiology. Heart and circulatory physiology. 2009 297:H1274-80. [PubMed:19684186]
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A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG. Molecular and cellular biology. 2009 29:5729-41. (WB; Mouse) [PubMed:19720742] [PMC:PMC2772748]
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Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury. Hammerschmidt E, Loeffler I, Wolf G. American journal of physiology. Renal physiology. 2009 297:F1273-87. [PubMed:19726548]
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Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation. Sims JR, Lee SW, Topalkara K, Qiu J, Xu J, Zhou Z, Moskowitz MA. Stroke; a journal of cerebral circulation. 2009 40:3618-26. [PubMed:19762700] [PMC:PMC2869495]
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Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:17910-5. (ChrIP; Human) [PubMed:19805192] [PMC:PMC2764905]
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Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia. Xia X, Kung AL. Genome biology. 2009 10:R113. (ChrIP; Human) [PubMed:19828020] [PMC:PMC2784328]
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HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization. Noguera R, Fredlund E, Piqueras M, Pietras A, Beckman S, Navarro S, Phlman S. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:7130-6. [PubMed:19903792]
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Construction of mutant TKGFP for real-time imaging of temporal dynamics of HIF-1 signal transduction activity mediated by hypoxia and reoxygenation in tumors in living mice. Hsieh CH, Kuo JW, Lee YJ, Chang CW, Gelovani JG, Liu RS. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2009 50:2049-57. [PubMed:19910419]
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Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation. Saini Y, Kim KY, Lewandowski R, Bramble LA, Harkema JR, Lapres JJ. American journal of physiology. Lung cellular and molecular physiology. 2010 298:L139-47. [PubMed:19915160] [PMC:PMC2822559]
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Hypoxia-inducible factor-1alpha regulates the expression of nucleotide excision repair proteins in keratinocytes. Rezvani HR, Mahfouf W, Ali N, Chemin C, Ged C, Kim AL, de Verneuil H, Taeb A, Bickers DR, Mazurier F. Nucleic acids research. 2010 38:797-809. [PubMed:19934262] [PMC:PMC2817476]
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Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity. Kim Y, Lin Q, Zelterman D, Yun Z. Cancer research. 2009 69:9271-80. [PubMed:19934310] [PMC:PMC2828615]
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Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL. The Journal of biological chemistry. 2010 285:3651-63. [PubMed:19940151] [PMC:PMC2823506]
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Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Rey S, Lee K, Wang CJ, Gupta K, Chen S, McMillan A, Bhise N, Levchenko A, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:20399-404. [PubMed:19948968] [PMC:PMC2787122]
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PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2. Choy MK, Movassagh M, Bennett MR, Foo RS. Journal of cellular physiology. 2010 222:635-9. (WB; Mouse, Rat) [PubMed:19950214]
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Human nephrosclerosis triggers a hypoxia-related glomerulopathy. Neusser MA, Lindenmeyer MT, Moll AG, Segerer S, Edenhofer I, Sen K, Stiehl DP, Kretzler M, Grne HJ, Schlndorff D, Cohen CD. The American journal of pathology. 2010 176:594-607. [PubMed:20019191] [PMC:PMC2808068]
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Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. Lee JJ, Natsuizaka M, Ohashi S, Wong GS, Takaoka M, Michaylira CZ, Budo D, Tobias JW, Kanai M, Shirakawa Y, Naomoto Y, Klein-Szanto AJ, Haase VH, Nakagawa H. Carcinogenesis. 2010 31:427-34. (WB; Human) [PubMed:20042640] [PMC:PMC2832548]
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Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression. Tanaka T, Wakamatsu T, Daijo H, Oda S, Kai S, Adachi T, Kizaka-Kondoh S, Fukuda K, Hirota K. American journal of physiology. Regulatory, integrative and comparative physiology. 2010 298:R661-71. [PubMed:20042684]
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Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP. Evens AM, Sehn LH, Farinha P, Nelson BP, Raji A, Lu Y, Brakman A, Parimi V, Winter JN, Schumacker PT, Gascoyne RD, Gordon LI. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010 28:1017-24. [PubMed:20048181] [PMC:PMC2834428]
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Hypoxia stimulates CXCR4 signalling in ileal carcinoids. Arvidsson Y, Bergstrm A, Arvidsson L, Kristiansson E, Ahlman H, Nilsson O. Endocrine-related cancer. 2010 17:303-16. (IHC; Human) [PubMed:20071457]
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Clinicopathological implications of expressions of hypoxia-related molecules in esophageal superficial squamous cell carcinoma. Ogane N, Yasuda M, Shimizu M, Miyazawa M, Kamoshida S, Ueda A, Takata K, Sakuma Y, Miyagi Y, Kameda Y. Annals of diagnostic pathology. 2010 14:23-9. (IHC; Human) [PubMed:20123453]
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Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. Hyvrinen J, Hassinen IE, Sormunen R, Mki JM, Kivirikko KI, Koivunen P, Myllyharju J. The Journal of biological chemistry. 2010 285:13646-57. [PubMed:20185832] [PMC:PMC2859527]
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Double immunohistochemical staining method for HIF-1alpha and its regulators PHD2 and PHD3 in formalin-fixed paraffin-embedded tissues. Vaughan MM, Toth K, Chintala S, Rustum YM. Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry. 2010 18:375-81. (IHC; Human) [PubMed:20216402] [PMC:PMC3215297]
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Partial pulmonary embolization disrupts alveolarization in fetal sheep. Filby CE, Hooper SB, Wallace MJ. Respiratory research. 2010 11:42. (IHC-P; Human) [PubMed:20416033] [PMC:PMC2873931]
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Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. Wu DC, Paulson RF. PloS one. 2010 5:e11303. (ChrIP; Mouse) [PubMed:20585586] [PMC:PMC2892039]
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Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors. Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Tsuya A, Nakamura Y, Naito T, Hayashi I, Serizawa M, Koh Y, Hanaoka H, Tominaga H, Oriuchi N, Kondo H, Nakajima T, Yamamoto N. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010 28:3746-53. (IHC; Human) [PubMed:20625125]
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Biologic correlates of F-FDG uptake on PET in pulmonary pleomorphic carcinoma. Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Tsuya A, Nakamura Y, Naito T, Hayashi I, Kondo H, Nakajima T, Yamamoto N. Lung cancer (Amsterdam, Netherlands). 2011 71:144-50. (IHC; Human) [PubMed:20646779]
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Retina-specific activation of a sustained hypoxia-like response leads to severe retinal degeneration and loss of vision. Lange C, Caprara C, Tanimoto N, Beck S, Huber G, Samardzija M, Seeliger M, Grimm C. Neurobiology of disease. 2011 41:119-30. [PubMed:20817091]
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Prognostic implications of hypoxia-inducible factor-1 in epidermal growth factor receptor-negative non-small cell lung cancer. Park S, Ha SY, Cho HY, Chung DH, Kim NR, Hong J, Cho EK. Lung cancer (Amsterdam, Netherlands). 2011 72:100-7. [PubMed:20822827]
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Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Chen H, Kluz T, Zhang R, Costa M. Carcinogenesis. 2010 31:2136-44. [PubMed:20881000] [PMC:PMC2994281]
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Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role. Espinosa I, Jos Carnicer M, Catasus L, Canet B, D'angelo E, Zannoni GF, Prat J. The American journal of surgical pathology. 2010 34:1708-14. [PubMed:20962622]
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Tissue inhibitor of metalloproteinases-1-induced scattered liver metastasis is mediated by hypoxia-inducible factor-1. Schelter F, Halbgewachs B, Bumler P, Neu C, Grlach A, Schrtzlmair F, Krger A. Clinical & experimental metastasis. 2011 28:91-9. (WB, IHC-Fr; Mouse) [PubMed:21053058]
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Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}. Gibbings S, Elkins ND, Fitzgerald H, Tiao J, Weyman ME, Shibao G, Fini MA, Wright RM. The Journal of biological chemistry. 2011 286:961-75. [PubMed:21059659] [PMC:PMC3020781]
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Diverging prognostic impacts of hypoxic markers according to NSCLC histology. Andersen S, Eilertsen M, Donnem T, Al-Shibli K, Al-Saad S, Busund LT, Bremnes RM. Lung cancer (Amsterdam, Netherlands). 2011 72:294-302. [PubMed:21075472]
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Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer. Jian J, Yang Q, Dai J, Eckard J, Axelrod D, Axelrod D, Smith J, Huang X. Free radical biology & medicine. 2011 50:841-7. [PubMed:21193031] [PMC:PMC3046244]
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HIF1A is essential for the development of the intermediate plexus of the retinal vasculature. Caprara C, Thiersch M, Lange C, Joly S, Samardzija M, Grimm C. Investigative ophthalmology & visual science. 2011 52:2109-17. [PubMed:21212189]
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Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells. Trisciuoglio D, Gabellini C, Desideri M, Ragazzoni Y, De Luca T, Ziparo E, Del Bufalo D. Cell death and differentiation. 2011 18:1024-35. (IP; Human) [PubMed:21233846] [PMC:PMC3131942]
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Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats. Lunde IG, Anton SL, Bruusgaard JC, Rana ZA, Ellefsen S, Gundersen K. The Journal of physiology. 2011 589:1443-54. (WB; Human, Rat) [PubMed:21262877] [PMC:PMC3082102]
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Hypoxia-inducible factor-1 (HIF-1) and autophagy in polycystic kidney disease (PKD). Belibi F, Zafar I, Ravichandran K, Segvic AB, Jani A, Ljubanovic DG, Edelstein CL. American journal of physiology. Renal physiology. 2011 300:F1235-43. (ICC, WB, IHC-Fr; Mouse, Rat) [PubMed:21270095] [PMC:PMC3094047]
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Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury. Hlscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, Wielockx B, Breier G, Katschinski DM, Zieseniss A. The Journal of biological chemistry. 2011 286:11185-94. [PubMed:21270129] [PMC:PMC3064173]
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Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?. Kim JA, Kim SJ, Do IG, Jin J, Nam DH, Ko YH, Kim K, Kim WS. Leukemia & lymphoma. 2011 52:205-13. (IHC; Human) [PubMed:21281236]
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NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning. Valsecchi V, Pignataro G, Del Prete A, Sirabella R, Matrone C, Boscia F, Scorziello A, Sisalli MJ, Esposito E, Zambrano N, Di Renzo G, Annunziato L. Stroke; a journal of cerebral circulation. 2011 42:754-63. (WB, ChrIP; Human) [PubMed:21293012]
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Acetaminophen hepatotoxicity and HIF-1 induction in acetaminophen toxicity in mice occurs without hypoxia. Chaudhuri S, McCullough SS, Hennings L, Letzig L, Simpson PM, Hinson JA, James LP. Toxicology and applied pharmacology. 2011 252:211-20. [PubMed:21316383] [PMC:PMC3099476]
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An improved method for the study of apoptosis-related genes using the tet-on system. Halterman MW. Journal of biomolecular screening. 2011 16:332-7. (WB; Mouse) [PubMed:21335597]
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Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Higashimura Y, Nakajima Y, Yamaji R, Harada N, Shibasaki F, Nakano Y, Inui H. Archives of biochemistry and biophysics. 2011 509:8-Jan. (WB, ChrIP; Human) [PubMed:21338575]
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Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Mller cells. Lin M, Chen Y, Jin J, Hu Y, Zhou KK, Zhu M, Le YZ, Ge J, Johnson RS, Ma JX. Diabetologia. 2011 54:1554-66. [PubMed:21360191]
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Hypoxia-inducible factor 1 regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver. Huang LJ, Chuang IC, Dong HP, Yang RC. Shock (Augusta, Ga.). 2011 36:90-6. (WB; Rat) [PubMed:21412184]
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Coexpression of hypoxia-inducible factor-1 and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients. Eckert AW, Lautner MH, Schtze A, Taubert H, Schubert J, Bilkenroth U. Histopathology. 2011 58:1136-47. [PubMed:21438910]
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Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration. Lange C, Heynen SR, Tanimoto N, Thiersch M, Le YZ, Meneau I, Seeliger MW, Samardzija M, Caprara C, Grimm C. Investigative ophthalmology & visual science. 2011 52:5872-80. [PubMed:21447692]
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Correlation between 18F-FDG uptake on PET and molecular biology in metastatic pulmonary tumors. Kaira K, Okumura T, Ohde Y, Takahashi T, Murakami H, Oriuchi N, Endo M, Kondo H, Nakajima T, Yamamoto N. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2011 52:705-11. [PubMed:21498541]
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Trichinella spiralis infection induces angiogenic factor thymosin 4 expression. Kang YJ, Jo JO, Cho MK, Yu HS, Ock MS, Cha HJ. Veterinary parasitology. 2011 181:222-8. (IHC, WB; Mouse) [PubMed:21531510]
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Hypoxia inducible factor-1 directly induces the expression of receptor activator of nuclear factor-B ligand in periodontal ligament fibroblasts. Park HJ, Baek KH, Lee HL, Kwon A, Hwang HR, Qadir AS, Woo KM, Ryoo HM, Baek JH. Molecules and cells. 2011 31:573-8. (WB; Human) [PubMed:21533547]
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Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium. Polosukhin VV, Cates JM, Lawson WE, Milstone AP, Matafonov AG, Massion PP, Lee JW, Randell SH, Blackwell TS. The Journal of pathology. 2011 224:203-11. [PubMed:21557221]
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Induction of hypoxia inducible factor (HIF-1) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Baek JH, Reiter CE, Manalo DJ, Buehler PW, Hider RC, Alayash AI. Biochimica et biophysica acta. 1809:262-8. (WB, IP; Human) [PubMed:21558026]
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Rapamycin decreases survivin expression to induce NSCLC cell apoptosis under hypoxia through inhibiting HIF-1 induction. Chen B, Yuping S, Ni J. Molecular biology reports. 2012 39:185-91. (WB; Human) [PubMed:21567203]
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The role of hypoxia-inducible factor-1 in acetaminophen hepatotoxicity. Sparkenbaugh EM, Saini Y, Greenwood KK, LaPres JJ, Luyendyk JP, Copple BL, Maddox JF, Ganey PE, Roth RA. The Journal of pharmacology and experimental therapeutics. 2011 338:492-502. [PubMed:21576378] [PMC:PMC3141908]
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Scaffold porosity and oxygenation of printed hydrogel constructs affect functionality of embedded osteogenic progenitors. Fedorovich NE, Kuipers E, Gawlitta D, Dhert WJ, Alblas J. Tissue engineering. Part A. 2011 17:2473-86. (IHC; Goat) [PubMed:21599540]
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IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis. Zhang C, Lu L, Li Y, Wang X, Zhou J, Liu Y, Fu P, Gallicchio MA, Bach LA, Duan C. International journal of cancer. Journal international du cancer. 2012 130:2003-12. (WB; Human) [PubMed:21618524] [PMC:PMC3259243]
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EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate. Pascal LE, Ai J, Rigatti LH, Lipton AK, Xiao W, Gnarra JR, Wang Z. Angiogenesis. 2011 14:331-43. [PubMed:21638067] [PMC:PMC3155049]
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MCM proteins are negative regulators of hypoxia-inducible factor 1. Hubbi ME, Luo W, Baek JH, Semenza GL. Molecular cell. 2011 42:700-12. (WB, IP; Human) [PubMed:21658608] [PMC:PMC3131976]
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Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats. Leh S, Hultstrm M, Rosenberger C, Iversen BM. Virchows Archiv : an international journal of pathology. 2011 459:99-108. [PubMed:21660521] [PMC:PMC3128263]
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Anti-VEGF antibody treatment accelerates polycystic kidney disease. Raina S, Honer M, Krmer SD, Liu Y, Wang X, Segerer S, Wthrich RP, Serra AL. American journal of physiology. Renal physiology. 2011 301:F773-83. [PubMed:21677148]
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Wnt--catenin signaling protects against hepatic ischemia and reperfusion injury in mice. Lehwald N, Tao GZ, Jang KY, Sorkin M, Knoefel WT, Sylvester KG. Gastroenterology. 2011 141:707-18, 718.e1-5. (WB; Mouse) [PubMed:21679710]
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The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: pathological consideration of their potential roles. Nonoguchi N, Miyatake S, Fukumoto M, Furuse M, Hiramatsu R, Kawabata S, Kuroiwa T, Tsuji M, Fukumoto M, Ono K. Journal of neuro-oncology. 2011 105:423-31. (IHC; Human) [PubMed:21688077]
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MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression. Wang Y, Huang JW, Li M, Cavenee WK, Mitchell PS, Zhou X, Tewari M, Furnari FB, Taniguchi T. Molecular cancer research : MCR. 2011 9:1100-11. [PubMed:21693595] [PMC:PMC3157593]
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Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis. Sengupta T, Abraham G, Xu Y, Clurman BE, Minella AC. Molecular and cellular biology. 2011 31:3885-95. (WB; Human) [PubMed:21746877] [PMC:PMC3165725]
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Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase. Zhang XL, Yan ZW, Sheng WW, Xiao J, Zhang ZX, Ye ZB. Molecular and cellular biochemistry. 2011 358:287-95. (WB; Mouse) [PubMed:21755458]
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Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas. Kwon TG, Zhao X, Yang Q, Li Y, Ge C, Zhao G, Franceschi RT. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2011 (IHC; Human) [PubMed:21778086]
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Dimethyloxalylglycine stabilizes HIF-1 in cultured human endothelial cells and increases random-pattern skin flap survival in vivo. Shafighi M, Olariu R, Fathi AR, Djafarzadeh S, Jakob SM, Banic A, Constantinescu MA. Plastic and reconstructive surgery. 2011 128:415-22. (WB; Human) [PubMed:21788833]
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Physical and functional interactions between Runx2 and HIF-1 induce vascular endothelial growth factor gene expression. Kwon TG, Zhao X, Yang Q, Li Y, Ge C, Zhao G, Franceschi RT. Journal of cellular biochemistry. 2011 112:3582-93. [PubMed:21793044] [PMC:PMC3202060]
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The Loss of HIF1 Leads to Increased Susceptibility to Cadmium-Chloride-Induced Toxicity in Mouse Embryonic Fibroblasts. Vengellur A, Grier E, Lapres JJ. Journal of toxicology. 2011 2011:391074. [PubMed:21811500] [PMC:PMC3147003]
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Systemic hypoxia differentially affects neurogenesis during early mouse brain maturation. Schneider C, Krischke G, Rascher W, Gassmann M, Trollmann R. Brain & development. 2012 34:261-73. [PubMed:21824737]
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Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux. Le Lay S, Rodriguez M, Jessup W, Rentero C, Li Q, Cartland S, Grewal T, Gaus K. PloS one. 2011 6:e23353. [PubMed:21858084] [PMC:PMC3155548]
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Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner. Chiang CK, Tanaka T, Inagi R, Fujita T, Nangaku M. Laboratory investigation; a journal of technical methods and pathology. 2011 91:1564-71. [PubMed:21863063]
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Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. Hattori H, Okuda K, Murase T, Shigetsura Y, Narise K, Semenza GL, Nagasawa H. Bioorganic & medicinal chemistry. 2011 19:5392-401. [PubMed:21865046]
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Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM, Pan F. Cell. 2011 146:772-84. [PubMed:21871655] [PMC:PMC3387678]
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Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients. Peurala E, Koivunen P, Bloigu R, Haapasaari KM, Jukkola-Vuorinen A. Breast cancer research and treatment. 2012 133:179-88. (IHC; Human) [PubMed:21877141]
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Intermittent hypoxia after transient focal ischemia induces hippocampal neurogenesis and c-Fos expression and reverses spatial memory deficits in rats. Tsai YW, Yang YR, Wang PS, Wang RY. PloS one. 2011 6:e24001. [PubMed:21887361] [PMC:PMC3161088]
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Methionine sulfoxide reductase A: Structure, function and role in ocular pathology. Sreekumar PG, Hinton DR, Kannan R. World journal of biological chemistry. 2011 2:184-92. [PubMed:21909460] [PMC:PMC3163237]
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Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction. Olson N, Hristova M, Heintz NH, Lounsbury KM, van der Vliet A. American journal of physiology. Lung cellular and molecular physiology. 2011 301:L993-L1002. [PubMed:21926263] [PMC:PMC3233830]
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NADPH oxidase subunit 4-mediated reactive oxygen species contribute to cycling hypoxia-promoted tumor progression in glioblastoma multiforme. Hsieh CH, Shyu WC, Chiang CY, Kuo JW, Shen WC, Liu RS. PloS one. 2011 6:e23945. [PubMed:21935366] [PMC:PMC3174133]
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Hypoxia inducible factor expression in intrahepatic cholangiocarcinoma. Morine Y, Shimada M, Utsunomiya T, Imura S, Ikemoto T, Mori H, Hanaoka J, Kanamoto M, Iwahashi S, Miyake H. Hepato-gastroenterology. 58:1439-44. [PubMed:21940327]
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Thymidylate synthase expression is closely associated with outcome in patients with pulmonary adenocarcinoma. Kaira K, Ohde Y, Nakagawa K, Okumura T, Murakami H, Takahashi T, Kondo H, Nakajima T, Endo M, Yamamoto N. Medical oncology (Northwood, London, England). 2012 29:1663-72. (IHC; Human) [PubMed:21948461]
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MUC1 expression in pulmonary metastatic tumors: a comparison of primary lung cancer. Kaira K, Okumura T, Nakagawa K, Ohde Y, Takahashi T, Murakami H, Naito T, Endo M, Kondo H, Nakajima T, Yamamoto N. Pathology oncology research : POR. 2012 18:439-47. (IHC; Human) [PubMed:21964914]
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Differential impact of EGFR-targeted therapies on hypoxia responses: implications for treatment sensitivity in triple-negative metastatic breast cancer. El Guerrab A, Zegrour R, Nemlin CC, Vigier F, Cayre A, Penault-Llorca F, Rossignol F, Bignon YJ. PloS one. 2011 6:e25080. [PubMed:21966417] [PMC:PMC3178587]
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Cell-autonomous and non-cell-autonomous neuroprotective functions of ROR in neurons and astrocytes during hypoxia. Jolly S, Journiac N, Naudet F, Gautheron V, Mariani J, Vernet-der Garabedian B. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:14314-23. [PubMed:21976517]
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Role of histone deacetylase expression in intrahepatic cholangiocarcinoma. Morine Y, Shimada M, Iwahashi S, Utsunomiya T, Imura S, Ikemoto T, Mori H, Hanaoka J, Miyake H. Surgery. 2012 151:412-9. (IHC; Human) [PubMed:21982637]
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Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice. Milesi-Hall A, McCullough S, Hinson JA, Kurten RC, Lamps LW, Brown A, James LP. Basic & clinical pharmacology & toxicology. 2012 110:327-34. (WB; Mouse) [PubMed:21985601] [PMC:PMC3289727]
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Choline phosphorylation and regulation of transcription of choline kinase in hypoxia. Bansal A, Harris RA, DeGrado TR. Journal of lipid research. 2012 53:149-57. [PubMed:22025560] [PMC:PMC3243471]
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Genetic and functional studies implicate HIF1 as a 14q kidney cancer suppressor gene. Shen C, Beroukhim R, Schumacher SE, Zhou J, Chang M, Signoretti S, Kaelin WG. Cancer discovery. 2011 1:222-35. [PubMed:22037472] [PMC:PMC3202343]
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Role of FDG-PET as a biological marker for predicting the hypoxic status of tongue cancer. Han MW, Lee HJ, Cho KJ, Kim JS, Roh JL, Choi SH, Nam SY, Kim SY. Head & neck. 2012 34:1395-402. (IHC; Human) [PubMed:22052623]
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18F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: a clinicopathological study. Kaira K, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Hayashi I, Oriuchi N, Endo M, Kondo H, Nakajima T, Yamamoto N. European journal of radiology. 2012 81:2423-9. (IHC; Human) [PubMed:22055682]
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Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1. Ogle ME, Gu X, Espinera AR, Wei L. Neurobiology of disease. 2012 45:733-42. [PubMed:22061780] [PMC:PMC3286647]
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Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors. Tan SC, Carr CA, Yeoh KK, Schofield CJ, Davies KE, Clarke K. Molecular biology reports. 2012 39:4857-67. (WB; Rat) [PubMed:22065248] [PMC:PMC3294216]
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Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism. Cartee TV, White KJ, Newton-West M, Swerlick RA. Journal of dermatological science. 2012 65:86-94. [PubMed:22093255] [PMC:PMC3273579]
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Effects of oxygen on zonal marker expression in human articular chondrocytes. Schrobback K, Malda J, Crawford RW, Upton Z, Leavesley DI, Klein TJ. Tissue engineering. Part A. 2012 18:920-33. (ICC, IHC-Fr; Human) [PubMed:22097912]
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Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity. Edrey YH, Casper D, Huchon D, Mele J, Gelfond JA, Kristan DM, Nevo E, Buffenstein R. Aging cell. 2012 11:213-22. (WB; Mouse) [PubMed:22103690]
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Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss. Ly A, Yee P, Vessey KA, Phipps JA, Jobling AI, Fletcher EL. Investigative ophthalmology & visual science. 2011 52:9316-26. [PubMed:22110070]
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A myeloid hypoxia-inducible factor 1-Krppel-like factor 2 pathway regulates gram-positive endotoxin-mediated sepsis. Mahabeleshwar GH, Qureshi MA, Takami Y, Sharma N, Lingrel JB, Jain MK. The Journal of biological chemistry. 2012 287:1448-57. [PubMed:22110137] [PMC:PMC3256857]
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Interleukin-1beta-induced iNOS expression in human lung carcinoma A549 cells: involvement of STAT and MAPK pathways. Ravichandran K, Tyagi A, Deep G, Agarwal C, Agarwal R. Indian journal of experimental biology. 2011 49:840-7. [PubMed:22126015]
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Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1-mediated TRPC signalling. Chu W, Wan L, Zhao D, Qu X, Cai F, Huo R, Wang N, Zhu J, Zhang C, Zheng F, Cai R, Dong D, Lu Y, Yang B. Journal of cellular and molecular medicine. 2012 16:2022-34. (ICC, WB; Rat) [PubMed:22129453]
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Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs. Tang X, Lucas JE, Chen JL, LaMonte G, Wu J, Wang MC, Koumenis C, Chi JT. Cancer research. 2012 72:491-502. [PubMed:22135092] [PMC:PMC3261313]
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GSK-3 regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1. Flgel D, Grlach A, Kietzmann T. Blood. 2012 119:1292-301. [PubMed:22144179] [PMC:PMC3352078]
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2-Hydroxyestradiol slows progression of experimental polycystic kidney disease. Anderson S, Oyama TT, Lindsley JN, Schutzer WE, Beard DR, Gattone VH, Komers R. American journal of physiology. Renal physiology. 2012 302:F636-45. (WB; Rat) [PubMed:22160773] [PMC:PMC3353649]
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Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. Bohonowych JE, Peng S, Gopal U, Hance MW, Wing SB, Argraves KM, Lundgren K, Isaacs JS. BMC cancer. 2011 11:520. [PubMed:22172030] [PMC:PMC3259130]
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A dual role for hypoxia inducible factor-1 in the hepatitis C virus lifecycle and hepatoma migration. Wilson GK, Brimacombe CL, Rowe IA, Reynolds GM, Fletcher NF, Stamataki Z, Bhogal RH, Simes ML, Ashcroft M, Afford SC, Mitry RR, Dhawan A, Mee CJ, Hbscher SG, Balfe P, McKeating JA. Journal of hepatology. 2012 56:803-9. (ICC, IHC; Human) [PubMed:22178269] [PMC:PMC3343261]
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Iron facilitator LS081 reduces hypoxia-inducible factor-1 protein and functions as anticancer agent in hepatocellular carcinoma. Tanaka H, Li Z, Ikuta K, Addo L, Akutsu H, Nakamura M, Sasaki K, Ohtake T, Fujiya M, Torimoto Y, Glass J, Kohgo Y. Cancer science. 2012 103:767-74. (WB; Human) [PubMed:22181812]
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Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells. Doe MR, Ascano JM, Kaur M, Cole MD. Cancer research. 2012 72:949-57. [PubMed:22186139] [PMC:PMC3288382]
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Loss of epidermal hypoxia-inducible factor-1 accelerates epidermal aging and affects re-epithelialization in human and mouse. Rezvani HR, Ali N, Serrano-Sanchez M, Dubus P, Varon C, Ged C, Pain C, Cario-Andr M, Seneschal J, Taeb A, de Verneuil H, Mazurier F. Journal of cell science. 2011 124:4172-83. [PubMed:22193962]
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Hypoxic preconditioning increases iron transport rate in astrocytes. Yang L, Fan M, Du F, Gong Q, Bi ZG, Zhu ZJ, Zhu LL, Ke Y. Biochimica et biophysica acta. 2012 1822:500-8. [PubMed:22198321]
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Hypoxia-inducible factor 1 promotes primary tumor growth and tumor-initiating cell activity in breast cancer. Schwab LP, Peacock DL, Majumdar D, Ingels JF, Jensen LC, Smith KD, Cushing RC, Seagroves TN. Breast cancer research : BCR. 2012 14:R6. (WB; Mouse) [PubMed:22225988] [PMC:PMC3496121]
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Unfavourable consequences of chronic cardiac HIF-1 stabilization. Hlscher M, Schfer K, Krull S, Farhat K, Hesse A, Silter M, Lin Y, Pichler BJ, Thistlethwaite P, El-Armouche A, Maier LS, Katschinski DM, Zieseniss A. Cardiovascular research. 2012 94:77-86. [PubMed:22258630]
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Expansion of the fetoplacental vasculature in late gestation is strain dependent in mice. Rennie MY, Detmar J, Whiteley KJ, Jurisicova A, Adamson SL, Sled JG. American journal of physiology. Heart and circulatory physiology. 2012 302:H1261-73. (IHC, WB; Mouse) [PubMed:22268107] [PMC:PMC3311476]
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Hypoxia-inducible factor activation in myeloid cells contributes to the development of liver fibrosis in cholestatic mice. Copple BL, Kaska S, Wentling C. The Journal of pharmacology and experimental therapeutics. 2012 341:307-16. [PubMed:22271822] [PMC:PMC3336817]
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Increased activation of the hypoxia-inducible factor pathway in varicose veins. Lim CS, Kiriakidis S, Paleolog EM, Davies AH. Journal of vascular surgery. 2012 55:1427-39. (WB; Human) [PubMed:22277691]
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Effects of hypoxic preconditioning on the expression of iron influx and efflux proteins in primary neuron culture. Du F, Fan M, Gong Q, Zhu LL, Zhu ZJ, Lu L, Ke Y. Neurochemistry international. 2012 60:335-43. (WB; Rat) [PubMed:22281055]
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Transient ureteral obstruction prevents against kidney ischemia/reperfusion injury via hypoxia-inducible factor (HIF)-2 activation. Zhang S, Han CH, Chen XS, Zhang M, Xu LM, Zhang JJ, Xia Q. PloS one. 2012 7:e29876. [PubMed:22295069] [PMC:PMC3266244]
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Relationship between 18F-FDG uptake on positron emission tomography and molecular biology in malignant pleural mesothelioma. Kaira K, Serizawa M, Koh Y, Takahashi T, Hanaoka H, Oriuchi N, Endo M, Kondo H, Nakajima T, Yamamoto N. European journal of cancer (Oxford, England : 1990). 2012 48:1244-54. [PubMed:22330319]
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Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 in lung tumor. Hsieh YL, Chou LW, Chang PL, Yang CC, Kao MJ, Hong CZ. Environmental toxicology. 2012 [PubMed:22331677]
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Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury: possible involvements in hypoxia-inducible factor 1 (HIF-1). Hsieh YL, Chou LW, Chang PL, Yang CC, Kao MJ, Hong CZ. The Journal of comparative neurology. 2012 520:2903-16. [PubMed:22351621]
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HIG1, a novel regulator of mitochondrial -secretase, maintains normal mitochondrial function. Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 26:2306-17. (WB; Human) [PubMed:22355194]
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Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis. Xu Y, Li Q, Li XY, Yang QY, Xu WW, Liu GL. Journal of experimental & clinical cancer research : CR. 2012 31:16. (WB; Mouse) [PubMed:22357313] [PMC:PMC3310846]
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Correlation of a priori DCE-MRI and (1)H-MRS data with molecular markers in neck nodal metastases: Initial analysis. Jansen JF, Carlson DL, Lu Y, Stambuk HE, Moreira AL, Singh B, Patel SG, Kraus DH, Wong RJ, Shaha AR, Shah JP, Shukla-Dave A. Oral oncology. 2012 48:717-22. (IHC; Human) [PubMed:22366441] [PMC:PMC3368067]
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A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection. Okumura CY, Hollands A, Tran DN, Olson J, Dahesh S, von Kckritz-Blickwede M, Thienphrapa W, Corle C, Jeung SN, Kotsakis A, Shalwitz RA, Johnson RS, Nizet V. Journal of molecular medicine (Berlin, Germany). 2012 90:1079-89. (WB; Mouse) [PubMed:22371073] [PMC:PMC3606899]
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HIF-1 and c-Src mediate increased glucose uptake induced by endothelin-1 and connexin43 in astrocytes. Valle-Casuso JC, Gonzlez-Snchez A, Medina JM, Tabernero A. PloS one. 2012 7:e32448. [PubMed:22384254] [PMC:PMC3285680]
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Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features. Azab AK, Hu J, Quang P, Azab F, Pitsillides C, Awwad R, Thompson B, Maiso P, Sun JD, Hart CP, Roccaro AM, Sacco A, Ngo HT, Lin CP, Kung AL, Carrasco RD, Vanderkerken K, Ghobrial IM. Blood. 2012 119:5782-94. [PubMed:22394600] [PMC:PMC3382938]
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Hypoxia-inducible factor-1-regulated protein expression and oligodendroglioma patient outcome: comparison with established biomarkers and preoperative UCSF low-grade scoring system. Abraham S, Hu N, Jensen R. Journal of neuro-oncology. 2012 108:459-68. (IHC; Human) [PubMed:22396073]
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Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP. Cell. 2012 149:49-62. (WB; Mouse) [PubMed:22401813] [PMC:PMC3319228]
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Adrenomedullin promotes human endothelial cell proliferation via HIF-1. Chen L, Qiu JH, Zhang LL, Luo XD. Molecular and cellular biochemistry. 2012 365:263-73. (IHC, WB; Human) [PubMed:22406979]
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Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1. Wang Y, Roche O, Xu C, Moriyama EH, Heir P, Chung J, Roos FC, Chen Y, Finak G, Milosevic M, Wilson BC, Teh BT, Park M, Irwin MS, Ohh M. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:4892-7. (WB, GS; Human) [PubMed:22411794] [PMC:PMC3323978]
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Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1-mediated mRNA transcription and continuous protein synthesis. Natsuizaka M, Naganuma S, Kagawa S, Ohashi S, Ahmadi A, Subramanian H, Chang S, Nakagawa KJ, Ji X, Liebhaber SA, Klein-Szanto AJ, Nakagawa H. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 26:2620-30. (ChrIP; Human) [PubMed:22415309] [PMC:PMC3360153]
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Hypoxia-inducible factor-2 activation promotes colorectal cancer progression by dysregulating iron homeostasis. Xue X, Taylor M, Anderson E, Hao C, Qu A, Greenson JK, Zimmermann EM, Gonzalez FJ, Shah YM. Cancer research. 2012 72:2285-93. (WB; Mouse) [PubMed:22419665] [PMC:PMC3342485]
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Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through HIF-1 pathway. Song ZC, Zhou W, Shu R, Ni J. Cell proliferation. 2012 45:239-48. (WB; Human) [PubMed:22429763]
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Blockade of p53 by HIF-2, but not HIF-1, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells. Xu Y, Li Y, Pang Y, Ling M, Shen L, Jiang R, Zhao Y, Zhou J, Wang X, Liu Q. Archives of toxicology. 2012 86:947-59. (WB; Human) [PubMed:22447124]
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Nicotinic modulation of therapeutic response in vitro and in vivo. Warren GW, Romano MA, Kudrimoti MR, Randall ME, McGarry RC, Singh AK, Rangnekar VM. International journal of cancer. Journal international du cancer. 2012 131:2519-27. (IHC; Mouse) [PubMed:22447412]
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Prognostic impacts of hypoxic markers in soft tissue sarcoma. Smeland E, Kilvaer TK, Sorbye S, Valkov A, Andersen S, Bremnes RM, Busund LT, Donnem T. Sarcoma. 2012 2012:541650. (IHC; Human) [PubMed:22454562] [PMC:PMC3289941]
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Predicting outcomes of patients with intracranial meningiomas using molecular markers of hypoxia, vascularity, and proliferation. Jensen R, Lee J. Neurosurgery. 2012 71:146-56. (IHC; Human) [PubMed:22472549]
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Angiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats. Giani JF, Burghi V, Veiras LC, Tomat A, Muoz MC, Cao G, Turyn D, Toblli JE, Dominici FP. American journal of physiology. Renal physiology. 2012 302:F1606-15. (IHC, WB; Rat) [PubMed:22492942]
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Hypoxia and HIF-1 increase S100A8 and S100A9 expression in prostate cancer. Grebhardt S, Veltkamp C, Strbel P, Mayer D. International journal of cancer. Journal international du cancer. 2012 131:2785-94. (WB; Human) [PubMed:22505354]
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UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1 accumulation. Bandau S, Knebel A, Gage ZO, Wood NT, Alexandru G. BMC biology. 2012 10:36. (WB; Human) [PubMed:22537386] [PMC:PMC3349548]
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The Role of Hypoxia-Inducible Factor-1 and -2 in Androgen Insensitive Prostate Cancer Cells. Kaira K, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Shukuya T, Kenmotsu H, Naito T, Hayashi I, Oriuchi N, Endo M, Kondo H, Nakajima T, Yamamoto N. Urologic oncology. 2012 (WB; Human) [PubMed:22537539]
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Immunoexpression status and prognostic value of mammalian target of rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas. Chaux A, Schultz L, Albadine R, Hicks J, Kim JJ, Allaf ME, Carducci MA, Rodriguez R, Hammers HJ, Argani P, Reuter VE, Netto GJ. Human pathology. 2012 43:2129-37. (IHC; Human) [PubMed:22542128]
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The prognostic value of expression of HIF1, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy. Weber DC, Tille JC, Combescure C, Egger JF, Laouiti M, Hammad K, Granger P, Rubbia-Brandt L, Miralbell R. Radiation oncology (London, England). 2012 7:66. (IHC; Human) [PubMed:22546016] [PMC:PMC3432017]
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Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury. Sakamoto K, Hashimoto N, Kondoh Y, Imaizumi K, Aoyama D, Kohnoh T, Kusunose M, Kimura M, Kawabe T, Taniguchi H, Hasegawa Y. American journal of physiology. Lung cellular and molecular physiology. 2012 303:L43-53. (IHC, WB; Mouse, Human) [PubMed:22561461]
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Liposome-encapsulated hemoglobin attenuates cardiac dysfunction and sympathetic activity during hypohemoglobinemic shock. Nogami Y, Takase B, Kinoshita M, Shono S, Kaneda S, Tanaka Y, Kishimoto S, Hattori H, Ishihara M. Shock (Augusta, Ga.). 2012 38:159-64. (IHC; Rat) [PubMed:22575999]
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Ischemia is the prime but not the only cause of human multipotent stromal cell death in tissue-engineered constructs in vivo. Becquart P, Cambon-Binder A, Monfoulet LE, Bourguignon M, Vandamme K, Bensidhoum M, Petite H, Logeart-Avramoglou D. Tissue engineering. Part A. 2012 18:2084-94. (IHC; Human) [PubMed:22578283]
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Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung. Jackson IL, Zhang X, Hadley C, Rabbani ZN, Zhang Y, Marks S, Vujaskovic Z. Free radical biology & medicine. 2012 53:337-46. (WB; Mouse) [PubMed:22588005]
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Soluble epoxide hydrolase activity determines the severity of ischemia-reperfusion injury in kidney. Lee JP, Yang SH, Lee HY, Kim B, Cho JY, Paik JH, Oh YJ, Kim DK, Lim CS, Kim YS. PloS one. 2012 7:e37075. (ICC; Human) [PubMed:22590647] [PMC:PMC3349654]
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N-acetylcysteine protects against hypoxia mimetic-induced autophagy by targeting the HIF-1 pathway in retinal ganglion cells. Yang L, Tan P, Zhou W, Zhu X, Cui Y, Zhu L, Feng X, Qi H, Zheng J, Gu P, Fan X, Chen H. Cellular and molecular neurobiology. 2012 32:1275-85. (ICC; Rat) [PubMed:22618532]
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Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging. Wang H, Chen Q, Lee SH, Choi Y, Johnson FB, Pignolo RJ. Aging cell. 2012 11:704-13. (ICC; Mouse) [PubMed:22621437] [PMC:PMC3400025]
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Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensing. Koch Y, van Frden B, Kaiser S, Klein D, Kibschull M, Schorle H, Carpinteiro A, Gellhaus A, Winterhager E. Biology of reproduction. 2012 87:37. (WB; Mouse) [PubMed:22623621]
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Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW. Development (Cambridge, England). 2012 139:2340-50. (ICC, IHC; Mouse) [PubMed:22627278] [PMC:PMC3367444]
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IL-1-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway. Bhawal UK, Ito Y, Tanimoto K, Sato F, Fujimoto K, Kawamoto T, Sasahira T, Hamada N, Kuniyasu H, Arakawa H, Kato Y, Abiko Y. Journal of cellular biochemistry. 2012 113:3246-53. (IHC; Human) [PubMed:22644784]
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Hypoxia modulation of peroxisome proliferator-activated receptors (PPARs) in human glioblastoma stem cells. Implications for therapy. Galzio R, Cristiano L, Fidoamore A, Cifone MG, Benedetti E, Cinque B, Menghini P, Raysi Dehcordi S, Ippoliti R, Giordano A, Cimini A. Journal of cellular biochemistry. 2012 113:3342-52. (ICC, Flo; Human) [PubMed:22644833]
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Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism. Bardella C, Olivero M, Lorenzato A, Geuna M, Adam J, O'Flaherty L, Rustin P, Tomlinson I, Pollard PJ, Di Renzo MF. Molecular and cellular biology. 2012 32:3081-94. (WB; Human) [PubMed:22645311] [PMC:PMC3434507]
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Identification of a molecular signature underlying inhibition of mammary carcinoma growth by dietary N-3 fatty acids. Jiang W, Zhu Z, McGinley JN, El Bayoumy K, Manni A, Thompson HJ. Cancer research. 2012 72:3795-806. (WB; Rat) [PubMed:22651929]
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Hypoxia upregulates CD147 through a combined effect of HIF-1 and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors. Ke X, Fei F, Chen Y, Xu L, Zhang Z, Huang Q, Zhang H, Yang H, Chen Z, Xing J. Carcinogenesis. 2012 33:1598-607. (ChrIP; Human) [PubMed:22678117]
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Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2. Pourvali K, Matak P, Latunde-Dada GO, Solomou S, Mastrogiannaki M, Peyssonnaux C, Sharp PA. FEBS letters. 2012 586:2423-7. (WB; Human) [PubMed:22684009]
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Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension. Zhu Q, Liu M, Han WQ, Li PL, Wang Z, Li N. Journal of cellular and molecular medicine. 2012 16:2701-7. (WB; Rat) [PubMed:22686466] [PMC:PMC3461349]
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Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer. Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Okui T, Hu GF, Sasaki A. Oral oncology. 2012 48:1120-7. (IHC, WB; Human) [PubMed:22694909]
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Acute hypoxia induces apoptosis of pancreatic -cell by activation of the unfolded protein response and upregulation of CHOP. Zheng X, Zheng X, Wang X, Ma Z, Gupta Sunkari V, Botusan I, Takeda T, Bjrklund A, Inoue M, Catrina SB, Brismar K, Poellinger L, Pereira TS. Cell death & disease. 2012 3:e322. (WB; Mouse) [PubMed:22695615] [PMC:PMC3388238]
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Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage. Singh AK, Mukhopadhyay C, Biswas S, Singh VK, Mukhopadhyay CK. PloS one. 2012 7:e38489. (WB; Mouse) [PubMed:22701652] [PMC:PMC3373497]
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The role of androgens on hypoxia-inducible factor (HIF)-1-induced angiogenesis and on the survival of ischemically challenged skin flaps in a rat model. Shafighi M, Olariu R, Brun C, Fathi AR, Djafarzadeh S, Jakob SM, Hunger RE, Banic A, Constantinescu MA. Microsurgery. 2012 32:475-81. (WB; Human) [PubMed:22707412]
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Involvement of decreased hypoxia-inducible factor 1 activity and resultant G(1)-S cell cycle transition in radioresistance of perinecrotic tumor cells. Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S. Oncogene. 2012 (IHC; Human) [PubMed:22710721]
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NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme. Hsieh CH, Wu CP, Lee HT, Liang JA, Yu CY, Lin YJ. Free radical biology & medicine. 2012 53:649-58. (ICC, IHC-Fr; Mouse) [PubMed:22713363]
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A novel role for the transcription factor HIF-1 in the formation of mast cell extracellular traps. Branitzki-Heinemann K, Okumura CY, Vllger L, Kawakami Y, Kawakami T, Naim HY, Nizet V, Von Kckritz-Blickwede M. The Biochemical journal. 2012 446:159-63. (ICC; Human) [PubMed:22738198] [PMC:PMC3606900]
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Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1 via activation of PGE(2)-cAMP signaling. Lee J, Jung E, Hyun JW, Park D. Journal of cellular biochemistry. 2012 113:3681-91. (WB; Human) [PubMed:22753248]
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Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S. The Journal of cell biology. 2012 198:103-14. (WB, IP, ChrIP; Mouse) [PubMed:22753893] [PMC:PMC3392936]
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Hypoxia inducible factor-1 is necessary for invasive phenotype in Vegf-deleted islet cell tumors. Takeda T, Okuyama H, Nishizawa Y, Tomita S, Inoue M. Scientific reports. 2012 2:494. (WB; Mouse) [PubMed:22768384] [PMC:PMC3389366]
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Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis. Kiss J, Mollenhauer M, Walmsley SR, Kirchberg J, Radhakrishnan P, Niemietz T, Dudda J, Steinert G, Whyte MK, Carmeliet P, Mazzone M, Weitz J, Schneider M. Journal of immunology (Baltimore, Md. : 1950). 2012 189:1955-65. (WB; Mouse) [PubMed:22786772]
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Glucotoxicity induces glucose-6-phosphatase catalytic unit expression by acting on the interaction of HIF-1 with CREB-binding protein. Gautier-Stein A, Soty M, Chilloux J, Zitoun C, Rajas F, Mithieux G. Diabetes. 2012 61:2451-60. [PubMed:22787137] [PMC:PMC3447892]
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Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition. Chintala S, Najrana T, Toth K, Cao S, Durrani FA, Pili R, Rustum YM. BMC cancer. 2012 12:293. (IHC, WB; Human) [PubMed:22804960] [PMC:PMC3466155]
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Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma. Boysen G, Bausch-Fluck D, Thoma CR, Nowicka AM, Stiehl DP, Cima I, Luu VD, von Teichman A, Hermanns T, Sulser T, Ingold-Heppner B, Fankhauser N, Wenger RH, Krek W, Schraml P, Wollscheid B, Moch H. Neoplasia (New York, N.Y.). 2012 14:535-46. (WB, ChrIP; Human) [PubMed:22806541] [PMC:PMC3394196]
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Expression of cardiac GATA4 and downstream genes after exercise training in the db/db mouse. Broderick TL, Parrott CR, Wang D, Jankowski M, Gutkowska J. Pathophysiology : the official journal of the International Society for Pathophysiology / ISP. 2012 19:193-203. (WB; Mouse) [PubMed:22809789]
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Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis. Omarova S, Charvet CD, Reem RE, Mast N, Zheng W, Huang S, Peachey NS, Pikuleva IA. The Journal of clinical investigation. 2012 122:3012-23. (ICC, IHC-Fr; Mouse) [PubMed:22820291] [PMC:PMC3408752]
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Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells. Shimojo Y, Akimoto M, Hisanaga T, Tanaka T, Tajima Y, Honma Y, Takenaga K. Clinical & experimental metastasis. 2013 30:143-54. (ICC; Human) [PubMed:22833345]
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Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle. Roudier E, Forn P, Perry ME, Birot O. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 26:4530-9. (WB; Rat) [PubMed:22835827] [PMC:PMC3475253]
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Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle. Basic VT, Tadele E, Elmabsout AA, Yao H, Rahman I, Sirsj A, Abdel-Halim SM. American journal of physiology. Lung cellular and molecular physiology. 2012 303:L519-27. (WB; Mouse) [PubMed:22842216] [PMC:PMC3468481]
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Hypoxia-inducible factor-1 (HIF1) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release. Hatano N, Itoh Y, Suzuki H, Muraki Y, Hayashi H, Onozaki K, Wood IC, Beech DJ, Muraki K. The Journal of biological chemistry. 2012 287:31962-72. (WB, ChrIP; Human) [PubMed:22843691] [PMC:PMC3442528]
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Low TLR9 expression defines an aggressive subtype of triple-negative breast cancer. Tuomela J, Sandholm J, Karihtala P, Ilvesaro J, Vuopala KS, Kauppila JH, Kauppila S, Chen D, Pressey C, Hrknen P, Harris KW, Graves D, Auvinen PK, Soini Y, Jukkola-Vuorinen A, Selander KS. Breast cancer research and treatment. 2012 135:481-93. (IHC, WB; Human) [PubMed:22847512]
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Glucose transporter 1 (GLUT1) of anaerobic glycolysis as predictive and prognostic values in neoadjuvant chemoradiotherapy and laparoscopic surgery for locally advanced rectal cancer. Shim BY, Jung JH, Lee KM, Kim HJ, Hong SH, Kim SH, Sun DS, Cho HM. International journal of colorectal disease. 2013 28:375-83. (IHC; Human) [PubMed:22847606]
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Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells. Muratsu-Ikeda S, Nangaku M, Ikeda Y, Tanaka T, Wada T, Inagi R. PloS one. 2012 7:e41462. (WB; Human) [PubMed:22859986] [PMC:PMC3408438]
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Impaired response of hypoxic sensor protein HIF-1 and its downstream proteins in the spinal motor neurons of ALS model mice. Sato K, Morimoto N, Kurata T, Mimoto T, Miyazaki K, Ikeda Y, Abe K. Brain research. 2012 1473:55-62. (ICC, IHC, WB; Mouse) [PubMed:22871270]
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Low density lipoprotein receptor-related protein 1 expression correlates with cholesteryl ester accumulation in the myocardium of ischemic cardiomyopathy patients. Cal R, Juan-Babot O, Brossa V, Roura S, Glvez-Montn C, Portoles M, Rivera M, Cinca J, Badimon L, Llorente-Corts V. Journal of translational medicine. 2012 10:160. (IHC; Human) [PubMed:22873206] [PMC:PMC3479056]
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The importance of GLUT3 for de novo lipogenesis in hypoxia-induced lipid loading of human macrophages. Li L, Liu B, Hversen L, Lu E, Magnusson LU, Sthlman M, Born J, Bergstrm G, Levin MC, Hultn LM. PloS one. 2012 7:e42360. (IHC; Human) [PubMed:22876317] [PMC:PMC3410913]
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Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG. Tsukamoto S, Yamashita S, Kim YH, Kumazoe M, Huang Y, Yamada K, Tachibana H. FEBS letters. 2012 586:3441-7. (WB; Mouse) [PubMed:22884420]
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Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis. Kang YJ, Jo JO, Cho MK, Yu HS, Ock MS, Cha HJ. Journal of gastroenterology. 2012 (IHC, WB; Rat) [PubMed:22886508]
407
p16, Cyclin D1, and HIF-1 Predict Outcomes of Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Definitive Intensity-Modulated Radiation Therapy. Rahimi AS, Wilson DD, Saylor DK, Stelow EB, Thomas CY, Reibel JF, Levine PA, Shonka DC, Jameson MJ, Read PW. International journal of otolaryngology. 2012 2012:685951. (IHC; Human) [PubMed:22888357] [PMC:PMC3409529]
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Endothelial Semaphorin 7A promotes neutrophil migration during hypoxia. Morote-Garcia JC, Napiwotzky D, Khler D, Rosenberger P. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:14146-51. (ChrIP; Human) [PubMed:22891341] [PMC:PMC3435204]
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Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1 and HIF2 in tumor-associated fibroblasts and human breast cancer cells. Chiavarina B, Martinez-Outschoorn UE, Whitaker-Menezes D, Howell A, Tanowitz HB, Pestell RG, Sotgia F, Lisanti MP. Cell cycle (Georgetown, Tex.). 2012 11:3280-9. (ICC, WB; Human) [PubMed:22894905] [PMC:PMC3466527]
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Anthracycline inhibits recruitment of hypoxia-inducible transcription factors and suppresses tumor cell migration and cardiac angiogenic response in the host. Tanaka T, Yamaguchi J, Shoji K, Nangaku M. The Journal of biological chemistry. 2012 287:34866-82. (WB, IP; Human) [PubMed:22908232] [PMC:PMC3471702]
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The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1 mRNA stability. Zhang D, Li J, Zhang M, Gao G, Zuo Z, Yu Y, Zhu L, Gao J, Huang C. The Journal of biological chemistry. 2012 287:34361-71. (WB; Mouse) [PubMed:22910906] [PMC:PMC3464542]
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Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice. Chiabrando D, Fiorito V, Marro S, Silengo L, Altruda F, Tolosano E. Blood cells, molecules & diseases. 2013 50:25-30. (WB, IP; Human) [PubMed:22921471]
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The role of hypoxic-inducible factor (HIF1) and aldolaseC protein in endometrial carcinogenesis: a retrospective study of 279 patients. Mhawech-Fauceglia P, Wang D, Samrao D, Menesses T, Godoy H, Ough F, Lele S, Liu S, Pejovic T. BMJ open. 2012 2: (IHC; Human) [PubMed:22923632] [PMC:PMC3432840]
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Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model. Kim KJ, Choi JS, Kang I, Kim KW, Jeong CH, Jeong JW. Journal of pineal research. 2013 54:264-70. (IHC; Mouse) [PubMed:22924616]
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Hypoxia inducible factor-1-mediated activation of survivin in cervical cancer cells. Bai H, Ge S, Lu J, Qian G, Xu R. The journal of obstetrics and gynaecology research. 2013 39:555-63. (IHC, WB; Human) [PubMed:22925504]
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Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes. Aro E, Khatri R, Gerard-O'Riley R, Mangiavini L, Myllyharju J, Schipani E. The Journal of biological chemistry. 2012 287:37134-44. (WB; Mouse) [PubMed:22930750] [PMC:PMC3481313]
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Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy. Yamasaki T, Kamba T, Kanno T, Inoue T, Shibasaki N, Arakaki R, Yamada T, Kondo K, Kamoto T, Nishiyama H, Ogawa O, Nakamura E. Cancer science. 2012 103:2027-37. (WB; Human) [PubMed:22931246]
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Hypoxia regulates CD44 and its variant isoforms through HIF-1 in triple negative breast cancer. Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM. PloS one. 2012 7:e44078. (WB; Human) [PubMed:22937154] [PMC:PMC3429433]
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Aldosterone deficiency adversely affects pregnancy outcome in mice. Todkar A, Di Chiara M, Loffing-Cueni D, Bettoni C, Mohaupt M, Loffing J, Wagner CA. Pflgers Archiv : European journal of physiology. 2012 464:331-43. (WB; Mouse) [PubMed:22941338]
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Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1. Chou CW, Wang CC, Wu CP, Lin YJ, Lee YC, Cheng YW, Hsieh CH. Neuro-oncology. 2012 14:1227-38. (IHC, WB; Human) [PubMed:22946104] [PMC:PMC3452342]
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Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Zhao Y, Xiong X, Jia L, Sun Y. Cell death & disease. 2012 3:e386. (WB; Human) [PubMed:22951983] [PMC:PMC3461362]
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miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target. Aguado-Fraile E, Ramos E, Senz-Morales D, Conde E, Blanco-Snchez I, Stamatakis K, del Peso L, Cuppen E, Brne B, Bermejo ML. PloS one. 2012 7:e44305. (ChrIP; Human) [PubMed:22962609] [PMC:PMC3433485]
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Upstream stimulatory factor 2 and hypoxia-inducible factor 2 (HIF2) cooperatively activate HIF2 target genes during hypoxia. Pawlus MR, Wang L, Ware K, Hu CJ. Molecular and cellular biology. 2012 32:4595-610. (WB, ChrIP; Human) [PubMed:22966206] [PMC:PMC3486188]
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Expression of MUC17 is regulated by HIF1-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer. Kitamoto S, Yokoyama S, Higashi M, Yamada N, Matsubara S, Takao S, Batra SK, Yonezawa S. PloS one. 2012 7:e44108. (WB; Human) [PubMed:22970168] [PMC:PMC3438193]
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Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:E2784-93. (ChrIP; Human) [PubMed:22988108] [PMC:PMC3478644]
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Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease. Ding A, Kalaignanasundaram P, Ricardo SD, Abdelkader A, Witting PK, Broughton BR, Kim HB, Wyse BF, Phillips JK, Evans RG. Clinical and experimental pharmacology & physiology. 2012 39:917-29. (ICC, IHC; Rat) [PubMed:23006058]
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Hypoxia inducible factor-1 induces chemoresistance phenotype in non-Hodgkin lymphoma cell line via up-regulation of Bcl-(xL). Eftedal I, Jrgensen A, Rsbjrgen R, Flatberg A, Brubakk AO. Leukemia & lymphoma. 2012 (IHC, WB; Human) [PubMed:23013270]
428
A validated regulatory network for Th17 cell specification. Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, Agarwal A, Huang W, Parkurst CN, Muratet M, Newberry KM, Meadows S, Greenfield A, Yang Y, Jain P, Kirigin FK, Birchmeier C, Wagner EF, Murphy KM, Myers RM, Bonneau R, Littman DR. Cell. 2012 151:289-303. (ChrIP; Mouse) [PubMed:23021777] [PMC:PMC3503487]
429
Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts. Sirvent A, Vigy O, Orsetti B, Urbach S, Roche S. Molecular & cellular proteomics : MCP. 2012 11:1937-50. (WB; Human) [PubMed:23023324] [PMC:PMC3518126]
430
Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin 51 and ERK-dependent signaling pathways. Clarke DN, Al Ahmad A, Lee B, Parham C, Auckland L, Fertala A, Kahle M, Shaw CS, Roberts J, Bix GJ. PloS one. 2012 7:e45257. (WB; Mouse) [PubMed:23028886] [PMC:PMC3444475]
431
The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells. Rider P, Kaplanov I, Romzova M, Bernardis L, Braiman A, Voronov E, Apte RN. Frontiers in immunology. 2012 3:290. (WB; Human) [PubMed:23049530] [PMC:PMC3442192]
432
MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma. Brenner RM, Slayden OD. International journal of urology : official journal of the Japanese Urological Association. 2012 (IHC; Human) [PubMed:23050614]
433
Hypoxia markers are expressed in interneurons exposed to recurrent seizures. Gualtieri F, Marinelli C, Longo D, Pugnaghi M, Nichelli PF, Meletti S, Biagini G. Neuromolecular medicine. 2013 15:133-46. (ICC, IHC; Human) [PubMed:23073716]
434
Upregulation of VEGF expression is associated with accumulation of HIF-1 in the skin of nave scleroderma patients. Brenner RM, Slayden OD. Modern rheumatology / the Japan Rheumatism Association. 2012 (IHC; Human) [PubMed:23096096]
435
MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors. Ortiz-Masi D, Dez I, Calatayud S, Hernndez C, Cosn-Roger J, Hinojosa J, Esplugues JV, Barrachina MD. Oncogene. 2012 (WB; Human) [PubMed:23108411]
436
Molecular and functional aspects of menstruation in the macaque. Brenner RM, Slayden OD. Reviews in endocrine & metabolic disorders. 2012 13:309-18. (IHC; Avian) [PubMed:23108498] [PMC:PMC3523117]
437
Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process. Ortiz-Masi D, Dez I, Calatayud S, Hernndez C, Cosn-Roger J, Hinojosa J, Esplugues JV, Barrachina MD. PloS one. 2012 7:e48535. (IP; Human) [PubMed:23119050] [PMC:PMC3485304]
438
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Luo W, Chang R, Zhong J, Pandey A, Semenza GL. Proceedings of the National Academy of Sciences of the United States of America. 2012 109:E3367-76. (ChrIP; Human) [PubMed:23129632] [PMC:PMC3523832]
439
Early genetic responses in rat vascular tissue after simulated diving. Eftedal I, Jrgensen A, Rsbjrgen R, Flatberg A, Brubakk AO. Physiological genomics. 2012 44:1201-7. [PubMed:23132759]
440
HIF-1 inhibition reduces nasal inflammation in a murine allergic rhinitis model. Zhou H, Chen X, Zhang WM, Zhu LP, Cheng L. PloS one. 2012 7:e48618. (IHC, WB; Mouse) [PubMed:23133644] [PMC:PMC3486851]
441
Hypoxia-inducible factor 1- induces miR-210 in normoxic differentiating myoblasts. Cicchillitti L, Di Stefano V, Isaia E, Crimaldi L, Fasanaro P, Ambrosino V, Antonini A, Capogrossi MC, Gaetano C, Piaggio G, Martelli F. The Journal of biological chemistry. 2012 287:44761-71. (WB; Mouse) [PubMed:23148210] [PMC:PMC3531789]
442
The critical role of mast cell-derived hypoxia-inducible factor-1 in human and mice melanoma growth. Jeong HJ, Oh HA, Nam SY, Han NR, Kim YS, Kim JH, Lee SJ, Kim MH, Moon PD, Kim HM, Oh HA. International journal of cancer. Journal international du cancer. 2013 132:2492-501. (IHC, WB; Mouse, Human) [PubMed:23161568]
443
A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer. Menon J, Doebele RC, Gomes S, Bevilacqua E, Reindl KM, Rosner MR. PloS one. 2012 7:e49893. (WB; Human) [PubMed:23166790] [PMC:PMC3499522]
444
The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb. Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, Jefferson LS. American journal of physiology. Endocrinology and metabolism. 2013 304:E229-36. (WB; Rat) [PubMed:23193052] [PMC:PMC3543567]
445
Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties. Reddy VD, Padmavathi P, Kavitha G, Saradamma B, Varadacharyulu N. Molecular and cellular biochemistry. 2013 375:39-47. (WB; Rat) [PubMed:23212448]
446
Sprouty2 expression controls endothelial monolayer integrity and quiescence. Peier M, Walpen T, Christofori G, Battegay E, Humar R. Angiogenesis. 2013 16:455-68. (WB; Mouse) [PubMed:23232625]
447
Effects of oxygen tension and IGF-I on HIF-1 protein expression in mouse blastocysts. Yoon J, Juhn KM, Ko JK, Yoon SH, Ko Y, Lee CY, Lim JH. Journal of assisted reproduction and genetics. 2013 30:99-105. (ICC, IHC; Mouse) [PubMed:23232974] [PMC:PMC3553358]
448
Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4. Chiang CK, Nangaku M, Tanaka T, Iwawaki T, Inagi R. American journal of physiology. Cell physiology. 2013 304:C342-53. (WB, ChrIP; Human) [PubMed:23242184]
449
Myeloid cell HIF-1 regulates asthma airway resistance and eosinophil function. Hebron ML, Lonskaya I, Sharpe K, Weerasinghe PP, Algarzae NK, Shekoyan AR, Moussa CE. Journal of molecular medicine (Berlin, Germany). 2012 (WB; Mouse) [PubMed:23250618]
450
Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6). Hebron ML, Lonskaya I, Sharpe K, Weerasinghe PP, Algarzae NK, Shekoyan AR, Moussa CE. The Journal of biological chemistry. 2013 288:4103-15. (WB; Mouse) [PubMed:23258539] [PMC:PMC3567661]
451
MicroRNA-183 upregulates HIF-1 by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells. Tanaka H, Sasayama T, Tanaka K, Nakamizo S, Nishihara M, Mizukawa K, Kohta M, Koyama J, Miyake S, Taniguchi M, Hosoda K, Kohmura E. Journal of neuro-oncology. 2013 111:273-83. (WB; Human) [PubMed:23263745]
452
The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Enzmann G, Mysiorek C, Gorina R, Cheng YJ, Ghavampour S, Hannocks MJ, Prinz V, Dirnagl U, Endres M, Prinz M, Beschorner R, Harter PN, Mittelbronn M, Engelhardt B, Sorokin L. Acta neuropathologica. 2013 125:395-412. (IHC; Human) [PubMed:23269317] [PMC:PMC3578720]
453
Suppression of experimental choroidal neovascularization by curcumin in mice. Xie P, Zhang W, Yuan S, Chen Z, Yang Q, Yuan D, Wang F, Liu Q. PloS one. 2012 7:e53329. (WB; Mouse) [PubMed:23285282] [PMC:PMC3532428]
454
miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling. Momose K, Minami A, Shimono Y, Mizutani K, Nobutani K, Azuma T, Takai Y. Genes to cells : devoted to molecular & cellular mechanisms. 2013 18:195-202. (WB; Human) [PubMed:23301758]
455
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. Chaturvedi P, Gilkes DM, Wong CC, Luo W, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. The Journal of clinical investigation. 2013 123:189-205. (WB, ChrIP; Human) [PubMed:23318994] [PMC:PMC3533298]
456
Hypoxia pathways and cellular stress activate pancreatic stellate cells: development of an organotypic culture model of thick slices of normal human pancreas. Rebours V, Albuquerque M, Sauvanet A, Ruszniewski P, Lévy P, Paradis V, Bedossa P, Couvelard A. PloS one. 2013 8:e76229. (IHC; Human) [Full Text Article] [PubMed:24098783] [PMC:PMC3786955] Related Antibodies: LS-B674.
457
ATF4 promotes bone angiogenesis by increasing VEGF expression and release in the bone environment. Zhu K, Jiao H, Li S, Cao H, Galson DL, Zhao Z, Zhao X, Lai Y, Fan J, Im HJ, Chen D, Xiao G. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2013 28:1870-1884. (IHC; Mouse) [Full Text Article] [PubMed:23649506] [PMC:PMC4394202] Related Antibodies: LS-B495.
458
Hypoxia-independent upregulation of placental hypoxia inducible factor-1a gene expression contributes to the pathogenesis of preeclampsia. Iriyama T, Wang W, Parchim NF, Song A, Blackwell SC, Sibai BM, Kellems RE, Xia Y. Hypertension. 2015 65:1307-15. (IHC, WB; Mouse, Human) [Full Text Article] [PubMed:25847948] [PMC:PMC4859813] Related Antibodies: LS-B2823.
459
Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1a-miR-210 Signaling. Bakirtzi K, Law IK, Xue X, Iliopoulos D, Shah YM, Pothoulakis C. Journal of immunology (Baltimore, Md. : 1950). 2016 196:4311-21. (WB; Human) [Full Text Article] [PubMed:27076683]
460
Hypoxia-driven Hif2a coordinates mouse liver regeneration by coupling parenchymal growth to vascular expansion. Kron P, Linecker M, Limani P, Schlegel A, Kambakamba P, Lehn JM, Nicolau C, Graf R, Humar B, Clavien PA. Hepatology (Baltimore, Md.). 2016 December;64:2198-2209. (Mouse) [Full Text Article] [PubMed:27628483] Related Antibodies: LS-B495.
461
Carbon ion radiotherapy of human lung cancer attenuates HIF-1 signaling and acts with considerably enhanced therapeutic efficiency. Subtil FS, Wilhelm J, Bill V, Westholt N, Rudolph S, Fischer J, Scheel S, Seay U, Fournier C, Taucher-Scholz G, Scholz M, Seeger W, Engenhart-Cabillic R, Rose F, Dahm-Daphi J, H[Character e4]nze J. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014 Mar;28:1412-21. [Full Text Article] [PubMed:24347608] Related Antibodies: LS-B495.
462
HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells. Malec V, Gottschald OR, Li S, Rose F, Seeger W, H[Character e4]nze J. Free radical biology & medicine. 2010 Jun;48:1626-35. [Full Text Article] [PubMed:20347035] Related Antibodies: LS-B495.
463
Loss of HIF-1 alpha in the notochord results in cell death and complete disappearance of the nucleus pulposus. Merceron C, Mangiavini L, Robling A, Wilson TL, Giaccia AJ, Shapiro IM, Schipani E, Risbud MV. PloS one. 9:e110768. [Full Text Article] [PubMed:25338007] [PMC:PMC4206488] Related Antibodies: LS-B495.
464
Loss of PINK1 attenuates HIF-1 alpha induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia. Lin W, Wadlington NL, Chen L, Zhuang X, Brorson JR, Kang UJ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Feb;34:3079-89. [Full Text Article] [PubMed:24553947] [PMC:PMC3931509] Related Antibodies: LS-B1503.
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Filtered by: None
Type
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (5)
Recombinant (23)
Target
HIF1A / HIF1 Alpha (29)
Tag
6His,N-terminus (3)
8His,N-terminus (1)
GST (1)
GST,N-terminus (1)
His (11)
His + GST (2)
His + MBP (1)
His + T7 (1)
His, N-Terminal (2)
Myc + DDK (4)
Species
Bovine (2)
Chicken (3)
Human (18)
Mouse (1)
Pig (1)
Rat (2)
Source
293T Cells (2)
E. coli (20)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purification
Purified (21)
Low Endotoxin Level
Low endotoxin level (1)
Biologically Active
Biologically active (1)
Publications
No (29)
Showing 1-25 of 29 results

Human HIF1A / HIF1 Alpha Protein (Recombinant His + T7) (aa218-506) - LS-G12857
E. coli
His + T7
35.9 kDa
10µg  $265.00; 50µg  $415.00; 100µg  $515.00; 200µg  $755.00; 1mg  $1,935.00; 500µg  $860.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Recombinant Hypoxia Inducible Factor 1 Alpha By SDS-PAGE

Mouse HIF1A / HIF1 Alpha Protein (Recombinant His, N-Terminal) (aa588-836) - LS-G12862
E. coli
His, N-Terminal
28.5 kDa
10µg  $255.00; 50µg  $405.00; 100µg  $495.00; 200µg  $740.00; 1mg  $1,890.00; 500µg  $845.00
Recombinant Hypoxia Inducible Factor 1 Alpha By SDS-PAGE

Human HIF1A / HIF1 Alpha Protein (Recombinant GST) (Full Length) - LS-G28823
Wheat Germ Extract
GST
109.1 kDa
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE of human HIF1A stained with Coomassie Blue

Human HIF1A / HIF1 Alpha Protein (Recombinant) - LS-G3447
E. coli
None
100µg 1mg/ml  $275.00; 0.5mg 1mg/ml  $485.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human HIF1A / HIF1 Alpha Protein (Recombinant 6His,N-terminus) (Leu400-Asn826) - LS-G26959
HEK 293 Cells
6His,N-terminus
60-80 kDa
10µg  $235.00; 50µg  $315.00; 100µg  $405.00
SDS-PAGE under reducing conditions and visualized by Coomassie blue staining

Human HIF1A / HIF1 Alpha Protein (Recombinant His) (aa579-826) - LS-G22578
E. coli
His
31.1 kD
1000µg  $1,245.00; 500µg  $785.00; 200µg  $475.00; 50µg  $275.00; 10µg  $235.00; 100µg  $355.00

Human HIF1A / HIF1 Alpha Protein (Recombinant GST,N-terminus) (aa717-826) - LS-G58837
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human HIF1A / HIF1 Alpha Protein (Over-Expression Cell Culture Supernatant 6His,N-terminus) (Leu400-Asn826) - LS-G26846
HEK 293 Cells
6His,N-terminus
49 kDa
200µl  $235.00

Human HIF1A / HIF1 Alpha Protein (Over-Expression Lysate 8His,N-terminus) (Leu400-Asn826) - LS-G26703
HEK 293 Cells
8His,N-terminus
49 kDa
100µg  $245.00

Human HIF1A / HIF1 Alpha Protein (Recombinant His) - LS-G975
E. coli
His
10µg 0.25mg/ml  $315.00; 50µg 0.25mg/ml  $695.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human HIF1A / HIF1 Alpha Protein (Recombinant His) - LS-G19661
E. coli
His
11.8 kDa
1µg  $195.00; 5µg  $255.00; 50µg  $1,260.00

Human HIF1A / HIF1 Alpha Protein (Recombinant His, N-Terminal) - LS-G132774
E. coli
His, N-Terminal
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
40kDa
10µg  $355.00; 50µg  $725.00; 200µg  $1,440.00; 100µg  $1,140.00; 1mg  $4,320.00; 500µg  $1,920.00
Active Hypoxia Inducible Factor 1 Alpha (HIF1a) by WB
Active Hypoxia Inducible Factor 1 Alpha (HIF1a) by SDS-PAGE

Rat HIF1A / HIF1 Alpha Protein (Recombinant His) (aa216-336) - LS-G12874
E. coli
His
15.6 kDa
10µg  $265.00; 50µg  $425.00; 100µg  $545.00; 200µg  $800.00; 1mg  $2,040.00; 500µg  $905.00
Recombinant Hypoxia Inducible Factor 1 Alpha By SDS-PAGE

Human HIF1A / HIF1 Alpha Protein (Recombinant His + GST) (aa575-826) - LS-G12853
E. coli
His + GST
59.4 kDa
10µg  $265.00; 50µg  $415.00; 100µg  $515.00; 200µg  $755.00; 1mg  $1,935.00; 500µg  $860.00
Recombinant Hypoxia Inducible Factor 1 Alpha By SDS-PAGE

Bovine HIF1A / HIF1 Alpha Protein (Recombinant His) (aa45-180) - LS-G12856
E. coli
His
17.3 kDa
10µg  $295.00; 50µg  $515.00; 100µg  $695.00; 200µg  $1,020.00; 1mg  $2,610.00; 500µg  $1,155.00
Recombinant Hypoxia Inducible Factor 1 Alpha By SDS-PAGE

Bovine HIF1A / HIF1 Alpha Protein (Recombinant His + MBP) (aa220-349) - LS-G12858
E. coli
His + MBP
61.6 kDa
10µg  $295.00; 50µg  $515.00; 100µg  $695.00; 200µg  $1,020.00; 1mg  $2,610.00; 500µg  $1,155.00
Recombinant Hypoxia Inducible Factor 1 Alpha By SDS-PAGE

Chicken HIF1A / HIF1 Alpha Protein (Recombinant His) (aa35-155) - LS-G12859
E. coli
His
15.5 kDa
10µg  $295.00; 50µg  $495.00; 100µg  $695.00; 200µg  $1,005.00; 1mg  $2,580.00; 500µg  $1,140.00
Recombinant Hypoxia Inducible Factor 1 Alpha By SDS-PAGE

Chicken HIF1A / HIF1 Alpha Protein (Recombinant His) (aa641-785) - LS-G12860
E. coli
His
17.1 kDa
10µg  $295.00; 50µg  $495.00; 100µg  $695.00; 200µg  $1,005.00; 1mg  $2,580.00; 500µg  $1,140.00
Recombinant Hypoxia Inducible Factor 1 Alpha By SDS-PAGE

Chicken HIF1A / HIF1 Alpha Protein (Recombinant His) (aa238-389) - LS-G12863
E. coli
His
18.9 kDa
10µg  $295.00; 50µg  $495.00; 100µg  $695.00; 200µg  $1,005.00; 1mg  $2,580.00; 500µg  $1,140.00
Recombinant Hypoxia Inducible Factor 1 Alpha By SDS-PAGE

Rat HIF1A / HIF1 Alpha Protein (Recombinant His) (aa641-810) - LS-G12868
E. coli
His
20.2 kDa
10µg  $265.00; 50µg  $425.00; 100µg  $545.00; 200µg  $800.00; 1mg  $2,040.00; 500µg  $905.00
Recombinant Hypoxia Inducible Factor 1 Alpha By SDS-PAGE

Pig HIF1A / HIF1 Alpha Protein (Recombinant His + GST) (aa585-824) - LS-G12872
E. coli
His + GST
57.9 kDa
10µg  $305.00; 50µg  $530.00; 100µg  $725.00; 200µg  $1,065.00; 1mg  $2,745.00; 500µg  $1,215.00
Recombinant Hypoxia Inducible Factor 1 Alpha By SDS-PAGE

Human HIF1A / HIF1 Alpha Protein (Recombinant His) - LS-G19818
E. coli
His
25.1 kDa
2µg  $195.00; 10µg  $255.00; 1mg  $5,460.00

Human HIF1A / HIF1 Alpha Protein (Recombinant) - LS-G19879
E. coli
None
40.0 kDa
10µg  $195.00; 50µg  $255.00; 1mg  $1,890.00

Human HIF1A / HIF1 Alpha Protein (Recombinant 6His,N-terminus) (Leu400-Asn826) - LS-G26576
E. coli
6His,N-terminus
49 kDa
10µg  $215.00; 50µg  $275.00; 100µg  $325.00
SDS-PAGE under reducing conditions and visualized by Coomassie blue staining

Human HIF1A / HIF1 Alpha Protein (Recombinant His) - LS-G882
E. coli
His
50µg 1mg/ml  $315.00; 250µg 1mg/ml  $695.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Showing 1-25 of 29 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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