Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Recombinant Human Dickkopf-related protein 2 is produced by our Mammalian expression system and the target gene encoding Asp251-Ile526 is expressed with a Fc tag at the N-terminus, 6His tag at the C-terminus.
Fc,N-terminus + 6His,C-terminus
Greater than 95% by SDS-PAGE
Less than 0.1 EU/µg protein (determined by LAL method).
Lyophilized protein should be stored at < -20°C. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
DKK2 Protein, DKK-2 Protein, Dickkopf homolog 2 Protein, Dickkopf related protein-2 Protein, HDkk-2 Protein, Dickkopf-2 Protein, Dickkopf-related protein 2 Protein
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.