DKK2

dickkopf WNT signaling pathway inhibitor 2

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

DKK2 (8)

Publications

No (8)

Tag

Fc, N-terminus (1)

Fc, N-terminus + 6His, C-terminus (1)

His (2)

His-SUMO (1)

Myc-DDK (Flag) (2)

Species

Human (7)

Source

293T Cells (1)

CHO Cells (1)

E. coli (3)

HEK 293 Cells (1)

Human Cells (1)

Mammalian Cells (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (2)

Biologically Active

Biologically active (1)

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Human DKK2 Protein (Recombinant) - LS-G133788

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

25.8 kDa or 31-36 kDa

Price:

10 µg/$349; 2 µg/$268

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Human DKK2 Protein (Recombinant His-SUMO) (aa34-259) - LS-G21931

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

41 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human DKK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84566

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.45 kDa

Price:

20 µg/$150

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DKK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101216

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.45 kDa

Price:

100 µg/$494

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Human DKK2 Protein (Recombinant His) - LS-G1918

Source:

E. coli

Tag:

His

Price:

20 µg/$361; 100 µg/$739; 4 µg/$261

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Human DKK2 Protein (Recombinant Fc, N-terminus) (Asp251-Ile526) - LS-G139560

Source:

Mammalian Cells

Tag:

Fc, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

58.9 kDa

Price:

10 µg/$288; 50 µg/$436

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Human DKK2 Protein (Recombinant Fc, N-terminus + 6His, C-terminus) (Asp251-Ile526) - LS-G39397

Source:

Human Cells

Tag:

Fc, N-terminus + 6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

58.9kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human DKK2 Protein (Recombinant His) (aa159-258) - LS-G13243

Source:

E. coli

Tag:

His

Molecular Weight:

12.9 kDa

Price:

10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359

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