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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PathPlus™ CD45RB Antibody aa79‑88 Monoclonal Flo,IHC LS‑B7886

Catalog Number Size Price
LS-B7886-0.1 0.1 mg $425 
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Anti-CD45RB antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Anti-CD45RB antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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PathPlus™ CD45RB Antibody aa79‑88 Monoclonal Flo,IHC LS‑B7886

Note: This antibody replaces LS-C46051
Antibody:
Mouse Monoclonal to Human CD45RB
Application:
IHC, IHC-P, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B7886-0.1
Toll Free North America
866-819-4732

Overview

Antibody:
Mouse Monoclonal to Human CD45RB
Application:
IHC, IHC-P, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
CD45RB is a splice isoform of CD45 (also called protein tyrosine phosphatase, receptor type, C), a glycoprotein receptor that is required for T-cell activation. Several different splice isoforms of the extracellular domain of CD45 are expressed on T cells, and the isoform expressed depends on the particular subpopulation of cell, the state of cell maturation, and whether the cells have been exposed to antigen. CD45RB is expressed in bone marrow and immune system tissues, on naive T cells, peripheral B cells, thymocytes, dendritic cells, and macrophages. CD45RB expression decreases as T cells progress from naive T cells to memory cells. It is positive in most leukemias and lymphomas, but negative in Langerhans cells and plasma cell tumors. J Exp Med. 1987;166(5):1548-1566. doi: 10.1084/jem.166.5.1548;Proc Natl Acad Sci U S A. 1988;85(19):7182-7186. doi: 10.1073/pnas.85.19.7182;Trends Immunol. 2006;27(3):146-153. doi: 10.1016/j.it.2006.01.001;Immunol Cell Biol. 1997;75(5):430-445. doi: 10.1038/icb.1997.68;Eur J Immunol 1995 25(2):317.
Target
Human CD45RB
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Clone
MEM-143
Conjugations
Unconjugated
Purification
Purified by protein-A affinity chromatography. Greater than 95% by SDS-PAGE.
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • Flow Cytometry
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Human peripheral blood lymphocytes.
Epitope
aa79-88
Specificity
The antibody MEM-143 reacts with a protein determinant of CD45RB, a 180-240 kDa single chain type I membrane glycoprotein, variant of CD45 (CD45RB isoform). CD45RB is expressed on a subset of T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells.The MEM-143 is therefore not neuraminidase sensitive like most other anti-CD45RB antibodies (including standard antibody MEM-55). The reactivity of the antibody MEM-143 can be blocked by a peptide including amino acids 79-88.
Presentation
PBS, pH 7.4, 15 mM Sodium Azide
Storage
Store at 2°C to 8°C. Do not freeze.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee

Validation

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
PathPlus™ Validated
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-CD45RB antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
PathPlus™ Validated
Anti-CD45RB antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Anti-CD45RB antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.

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Reviews (0)

Featured Products

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Species: Human
Applications: IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Human Tonsil, Lymphocytes: Formalin-Fixed, Paraffin-Embedded (FFPE)
Species: Human
Applications: IHC, IHC - Paraffin, IHC - Frozen, Immunoprecipitation, Flow Cytometry
Human Tonsil, Lymphocytes: Formalin-Fixed, Paraffin-Embedded (FFPE)
Species: Human
Applications: IHC, IHC - Paraffin, IHC - Frozen, Immunoprecipitation, Flow Cytometry
Anti-CD45RB antibody IHC of human spleen, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Applications: Flow Cytometry
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Species: Human
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Product
Species: Mouse
Applications: Immunoprecipitation, Flow Cytometry

Requested From: United States
Date Requested: 8/22/2019
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