Myelin Basic Protein (MBP) is the second most abundant protein of the myelin membrane sheath in the central nervous system. It is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. MBP has roles in myelin formation and stabilization, remyelination and brain development, and may be involved in signaling. MBP has a role in diseases of demyelination such as multiple sclerosis. It is expressed in oligodendrocytes and Schwann cells of the central nervous system. References: Cell mol Life Sci 2006 63(17):1945