Free fatty acid receptor 2 (FFAR2) is a G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. FFAR2 regulates the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake and the whole-body's energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. FFAR2 plays a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804