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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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FFAR2 / GPR43

free fatty acid receptor 2

G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604). Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016).

Gene Name: free fatty acid receptor 2
Family/Subfamily: GPCR , Carboxylic Acid
Synonyms: FFAR2, FFA2R, Free fatty acid receptor 2, G protein-coupled receptor 43, G-protein coupled receptor 43, LSSIG, GPR43, Gpcr43
Target Sequences: NM_005306 NP_005297.1 O15552

Filtered by: None
Target
FFAR2 / GPR43 (55)
Reactivity
Human (55)
Mouse (7)
Rat (7)
Chimpanzee (3)
Monkey (18)
Orangutan (3)
Pig (7)
Application
IHC (39)
IHC-P (38)
WB (14)
ELISA (20)
ICC (1)
IF (3)
Peptide-ELISA (1)
Host
rabbit (55)
Isotype
IgG (14)
Clonality
polyclonal pc (55)
Format
AP Conjugated (6)
APC Conjugated (6)
Azide-free (6)
Biotin Conjugated (8)
FITC Conjugated (8)
HRP Conjugated (8)
PE Conjugated (6)
Unconjugated (13)
Epitope
Extracellular Domain (14)
C-Terminus (12)
aa286-315 (8)
Cytoplasmic Domain (7)
Internal (7)
250-330 aa, C-terminal (1)
aa271-320 (1)
Publications
No (54)
Yes (1)
Showing 1-25 of 55 results

IHC-plus™ FFAR2 / GPR43 Antibody (C-Terminus) LS-A6598
Publications (1)
Publications (1)
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
ELISA, IHC, IHC-P
Unconjugated
50µg 1mg/ml  $425.00
Anti-GPR43 antibody IHC of human lung, alveolar macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (C-Terminus, Azide-free, HRP) LS-A106323
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
ELISA, IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-GPR43 antibody IHC of human lung, alveolar macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (C-Terminus, APC) LS-A106320
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
ELISA, IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-GPR43 antibody IHC of human lung, alveolar macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (C-Terminus, AP) LS-A106319
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
ELISA, IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-GPR43 antibody IHC of human lung, alveolar macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (aa271-320) LS-B5986
Rabbit Polyclonal (IgG) to Human FFAR2 / GPR43
Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50µl 1mg/ml  $425.00
Anti-GPR43 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Immunofluorescence analysis of COS7 cells, using FFAR2 Antibody. The picture on the right is blocked with the synthesized peptide.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain) LS-A6599
Rabbit Polyclonal to Human FFAR2 / GPR43
Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-FFAR2 / GPR43 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR43 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, Biotin) LS-A106327
Rabbit Polyclonal to Human FFAR2 / GPR43
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR43 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, FITC) LS-A106328
Rabbit Polyclonal to Human FFAR2 / GPR43
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR43 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, PE) LS-A106330
Rabbit Polyclonal to Human FFAR2 / GPR43
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR43 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, AP) LS-A106325
Rabbit Polyclonal to Human FFAR2 / GPR43
Human, Monkey
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR43 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, APC) LS-A106326
Rabbit Polyclonal to Human FFAR2 / GPR43
Human, Monkey
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR43 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, Azide-free, HRP) LS-A106329
Rabbit Polyclonal to Human FFAR2 / GPR43
Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR43 antibody IHC of human spleen, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Cytoplasmic Domain) LS-A1578
Rabbit Polyclonal to Human FFAR2 / GPR43
Mouse, Rat, Pig, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-FFAR2 / GPR43 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR43 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Internal) LS-A1586
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-GPR43 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR43 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain) LS-A6600
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
IHC, IHC-P
Unconjugated
50µg 1mg/ml  $425.00
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ FFAR2 / GPR43 Antibody (aa286-315) LS-B9101
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
IHC, IHC-P, WB
Unconjugated
200µl  $425.00
Human, Lung, Macrophages: Formalin-Fixed Paraffin-Embedded (FFPE)
FFAR2 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The FFAR2 antibody detected the FFAR2 protein (arrow).

FFAR2 / GPR43 Antibody (C-Terminus) LS-C358987
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30µl 1mg/ml  $205.00; 100µl 1mg/ml  $245.00; 200µl 1mg/ml  $305.00
Immunohistochemical analysis of GPR43 staining in human tonsil formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of GPR43 staining in THP1 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 ??C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

FFAR2 / GPR43 Antibody (C-Terminus) LS-C151906
Rabbit Polyclonal to Human FFAR2 / GPR43
Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $385.00
FFAR2 / GPR43 antibody Western Blot of Fetal Liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

FFAR2 / GPR43 Antibody (aa286-315, APC) LS-C214194
Rabbit Polyclonal (IgG) to Human FFAR2 / GPR43
Human
ELISA, WB
APC Conjugated
200µl 0.35mg/ml  $740.00

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, Biotin) LS-A106333
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FFAR2 / GPR43 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, FITC) LS-A106334
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FFAR2 / GPR43 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, AP) LS-A106331
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FFAR2 / GPR43 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, APC) LS-A106332
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FFAR2 / GPR43 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, Azide-free, HRP) LS-A106335
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FFAR2 / GPR43 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ FFAR2 / GPR43 Antibody (Extracellular Domain, PE) LS-A106336
Rabbit Polyclonal to Human FFAR2 / GPR43
Human
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-FFAR2 / GPR43 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FFAR2 / GPR43 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Showing 1-25 of 55 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).