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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
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866-206-6909 (Toll Free North America)
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PathPlusTM ANXA1 / Annexin A1 Antibodies
Annexin A1 (ANXA1, lipocortin 1) is a calcium-dependent, phospholipid-binding protein that inhibits phospholipase A2 and exerts anti-inflammatory activity. It is expressed in tissues such as the bone marrow and the immune system, lung, and the gastrointestinal tract and is localized to the cytoplasm, plasma membrane, and nucleus. Dysregulation of ANXA1 expression and changes in subcellular localization are associated with many cancers, some with increased expression and some with decreased expression depending on the tissue and state of disease progression. Staining is used to distinguish hairy cell leukemia from other B-cell malignancies. In normal tissues, ANXA1 stains positive in squamous epithelium of the esophagus, tonsil, placental trophoblasts, and infiltrating leukocytes across a variety of tissues. Int J Mol Sci. 2018;19(4):1045. doi: 10.3390/ijms19041045; Clin Sci (Lond). 2016;130(4):205-220. doi: 10.1042/CS20150415; J Exp Med. 2004;199(1):59-68. doi: 10.1084/jem.20031175; Lancet. 2004;363(9424):1869-1870 doi: 10.1016/S0140-6736(04)16356-3.

4 PathPlusTM Antibodies
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Mouse Monoclonal [clone AHC0011] (IgG1) to Human ANXA1 / Annexin A1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $250.00
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Rabbit Polyclonal to Human ANXA1 / Annexin A1
IHC-P
Unconjugated
100µg   100µl   1mg/ml   $425.00
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Mouse Monoclonal (IgG1) to Human ANXA1 / Annexin A1
Human
ELISA, IHC-P, WB
Unconjugated
0.1ml   $250.00
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Mouse Monoclonal (IgG) to Human ANXA1 / Annexin A1
Human
IHC, IHC-P
Unconjugated
100µl   1mg/ml   $254.00
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