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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
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866-206-6909 (Toll Free North America)
206-577-4565 (International)
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PathPlusTM ABCA4 Antibodies
ABCA4 (ATP-binding cassette, sub-family A, member 4, ABCR) is a membrane-associated protein that functions to transport various molecules across the photoreceptor cell membrane in retina photoreceptor cells. ABCA4 is retina-specific, with N-retinylidene-PE as a substrate. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2. In immunohistochemistry of normal tissue, ABCA4 has membranous positivity in photoreceptor cells in the retina. It also has some positivity in a few regions of the brain (Warren, 2009). References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; The Journal of Biological Chemistry. 2008. 283 (39): 26684–93, PMID: 18658157; Warren et al. Pharmacol Res. 2009 Jun;59(6):404-13, PMID: 19429473

2 PathPlusTM Antibodies
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ABCA4 Antibody - Human Retina: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
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Rabbit Polyclonal to Human ABCA4
IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
ABCA4 Antibody - Human Brain, Cortex
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Cancer
Rabbit Polyclonal (IgG) to Human ABCA4
Human
IHC, IHC-P
Unconjugated
50µl   0.55mg/ml   $425.00

Viewing 1-2 of 2 items