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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16159-100 | 100 µl (1 mg/ml) | $460 |
PathPlus™ Monoclonal Mouse anti‑Human PLAP / Alkaline Phosphatase Antibody (IHC) LS‑B16159
PathPlus™ Monoclonal Mouse anti‑Human PLAP / Alkaline Phosphatase Antibody (IHC) LS‑B16159
Note: This antibody replaces LS-C744554
Antibody:
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
PLAP / Alkaline Phosphatase Mouse anti-Human Monoclonal Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
PLAP (alkaline phosphatase, placental type, ALPP) is an allosteric enzyme expressed in the placenta. PLAP is a membrane-bound protein that functions to catalyze phosphate monoester hydrolysis and transphosphorylation. In immunohistochemistry of cancer, PLAP is marker used to identify seminoma and malignant germ cell tumors (embryonal carcinoma and dysgerminoma), and it is also positive in ovarian, breast, lung, stomach, and pancreatic carcinomas. In normal tissues, PLAP stains placental trophoblasts.
References: J Phys Chem B. 2014 Dec 11;118(49):14302-13, PMID: 25409280; J Lab Med. 2004. 28 (2): 109–115, DOI:10.1515/labmed.2004.018; Clin. Biochem. 20 (6): 387–92, PMID: 3325192.
Target
Human PLAP / Alkaline Phosphatase
Synonyms
ALPP | ALP | Alkaline phosphomonoesterase | Glycerophosphatase | PALP | PLAP | PLAP-1 | Alp1 | Germ-cell alkaline phosphatase | Nagao isozyme | Regan isozyme
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Monoclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Immunogen
Synthetic Placental Alkaline Phosphatase (PLAP)
Applications
- IHC (1:200 - 1:400)
- IHC - Paraffin (1:50)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Use Heat-induced epitope retrieval (HIER) Citrate buffer of pH 6.0 Recommended IHC controls tissues are Placenta. Resulting localization is Cytoplasmic
Presentation
0.5% BSA, 0.1% Kathon, Tris-Buffered Saline, DI H2O and 50% glycerol
Storage
Store at -20°C for up to 1 year.
Restrictions
For research use only. Intended for use by laboratory professionals.
About PLAP / Alkaline Phosphatase
Validation
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ PLAP / Alkaline Phosphatase Antibody for IHC LS-B16159 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Frozen, Flow Cytometry, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Frozen, Western blot, ELISA
Species:
Human
Applications:
IHC, Western blot, ELISA
Species:
Human
Applications:
Western blot, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/27/2024
Date Requested: 4/27/2024
