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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-B4737-250 250 µl (0.2 mg/ml) $485 
PECAM-1 / CD31 Antibody - Anti-CD31 antibody IHC of human kidney, glomerulus, Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
PECAM-1 / CD31 Antibody - Anti-CD31 antibody IHC of human lung, endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
PECAM-1 / CD31 Antibody - Anti-CD31 antibody IHC of human kidney, glomerulus, Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
PECAM-1 / CD31 Antibody - Anti-CD31 antibody IHC of human lung, endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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PathPlus™ PECAM‑1 / CD31 Antibody Polyclonal IHC LS‑B4737

PathPlus™ PECAM‑1 / CD31 Antibody Polyclonal IHC LS‑B4737

Note: This antibody replaces LS-C88609
Antibody:
Rabbit Polyclonal to Mouse PECAM-1 / CD31
Application:
IHC, IHC-P
Reactivity:
Mouse, Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$485 
LS-B4737-250
250 µl
0.2 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Mouse PECAM-1 / CD31
Application:
IHC, IHC-P
Reactivity:
Mouse, Human
Format:
Unconjugated, Unmodified

Specifications

Description
CD31 (PECAM-1) is a surface glycoprotein expressed on the surface of endothelial cells, platelets, granulocytes, and monocytes that acts as an inhibitory receptor in circulating platelets and leukocytes as well as n endothelial adhesive stress response protein. It functions to promote and maintain endothelial cell junctional integrity and the vascular permeability barrier. It is also useful as an angiogenesis marker in cancer, and increased staining of vessels within lymph nodes is an indicator of potential lymph node metastases of invasive ductal carcinoma of the breast. This protein is expressed in endothelial cells within capillaries and vessels. Curr Opin Hamatol 2016 23(3):253; Popiela, 2008; Zaha, 2014
Target
Mouse PECAM-1 / CD31
Host
Rabbit
Reactivity
Mouse, Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide corresponding to C-terminus of mouse CD31 protein.
Specificity
c-terminal
Presentation
10 mM PBS, pH 7.6, 15 mM Sodium Azide, 0.2% BSA
Storage
Stable for 2 years when stored at 2°C to 8°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About PECAM-1 / CD31
P16284 NM_000442 NP_000433.4

Validation

PECAM-1 / CD31 Antibody - Anti-CD31 antibody IHC of human kidney, glomerulus, Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CD31 antibody IHC of human kidney, glomerulus, Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CD31 antibody IHC of human kidney, glomerulus, Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

PECAM-1 / CD31 Antibody - Anti-CD31 antibody IHC of human lung, endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CD31 antibody IHC of human lung, endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CD31 antibody IHC of human lung, endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Publications (3)

Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis. Yuan K, Orcholski ME, Panaroni C, Shuffle EM, Huang NF, Jiang X, Tian W, Vladar EK, Wang L, Nicolls MR, Wu JY, de Jesus Perez VA. The American journal of pathology. Jan;185:69-84.

Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension. Yuan K, Shao NY, Hennigs JK, Discipulo M, Orcholski ME, Shamskhou E, Richter A, Hu X, Wu JC, de Jesus Perez VA. The American journal of pathology. 2016 186:2500-14. (IF; Human)

Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse. Osmanagic-Myers S, Kiss A, Manakanatas C, Hamza O, Sedlmayer F, Szabo PL, Fischer I, Fichtinger P, Podesser BK, Eriksson M, Foisner R. The Journal of clinical investigation. 2019 February;129:531-545.

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Requested From: United States
Date Requested: 11/20/2019