Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Catalog Number Size Price
LS-A5395-50 50 µg (1 mg/ml) $460 
NR0B2 Antibody - Ovary, carcinoma
NR0B2 Antibody - Pancreas, carcinoma
NR0B2 Antibody - Anti-NR0B2 antibody IHC staining of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NR0B2 Antibody - Breast, carcinoma
NR0B2 Antibody - Ovary, carcinoma
NR0B2 Antibody - Pancreas, carcinoma
NR0B2 Antibody - Anti-NR0B2 antibody IHC staining of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NR0B2 Antibody - Breast, carcinoma
1 of 4
2 of 4
3 of 4
4 of 4

PathPlus™ Polyclonal Rabbit anti‑Human NR0B2 Antibody (C‑Terminus, IHC) LS‑A5395

PathPlus™ Polyclonal Rabbit anti‑Human NR0B2 Antibody (C‑Terminus, IHC) LS‑A5395

Antibody:
NR0B2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Format:
Unconjugated, Unmodified
Price
Catalog Number
$460
LS-A5395-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
NR0B2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Format:
Unconjugated, Unmodified

Specifications

Description
SHP (short heterodimer partner) is a bile acid-dependent orphan NR0 Knirps-Like receptor with dimerization and ligand-binding domains but not the conventional DNA-binding domain. SHP has been shown to inhibit the transcriptional activity of other nuclear receptors, including thyroid hormone receptor, constitutive androstane receptor, and retinoic acid receptors. SHP affects hepatic cholesterol catabolism based on a two-step mechanism dependent on both coactivator competition and direct transcriptional repression by mediating the repression of CYP7A1, the rate-limiting enzyme for bile acid synthesis. Mutations in the SHP gene contribute to increased body weight, indicating a possible role of SHP in the development of early-onset diabetes (maturity-onset diabetes of the young, MODY). Loss of SHP in mice caused abnormal accumulation and increased synthesis of bile acids due to derepression of rate-limiting CYP7A1 and CYP8B1 hydroxylase enzymes in the biosynthetic pathway. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human NR0B2
Synonyms
NR0B2 | Short heterodimer partner | SHP | Nuclear receptor SHP | Orphan nuclear receptor SHP | Small heterodimer partner | SHP1
Host
Rabbit
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 14 amino acid peptide near C-Terminus of human NR0B2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon, Monkey, Marmoset (100%); Gorilla, Tamarin, Bat (93%); Hamster, Panda, Rabbit, Horse (86%).
Epitope
C-Terminus
Specificity
Human NR0B2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (21 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About NR0B2
Q15466 NM_021969 NP_068804.1

Validation

NR0B2 Antibody - Ovary, carcinoma
Ovary, carcinoma
Ovary, carcinoma

NR0B2 Antibody - Pancreas, carcinoma
Pancreas, carcinoma
Pancreas, carcinoma

NR0B2 Antibody - Anti-NR0B2 antibody IHC staining of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR0B2 antibody IHC staining of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR0B2 antibody IHC staining of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

NR0B2 Antibody - Breast, carcinoma
Breast, carcinoma
Breast, carcinoma

LSBio Ratings

PathPlus™ NR0B2 Antibody (C-Terminus) for IHC LS-A5395 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/17/2021