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Catalog Number Size Price
LS-B16255-100 100 µg (200 µg/ml) $485 
NKX2-2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
NKX2-2 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
NKX2-2 Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
NKX2-2 Antibody - SDS-PAGE Analysis Purified NKX2.2 Mouse Recombinant Monoclonal Antibody (rNX2/294). Confirmation of Purity and Integrity of Antibody.
NKX2-2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
NKX2-2 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
NKX2-2 Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
NKX2-2 Antibody - SDS-PAGE Analysis Purified NKX2.2 Mouse Recombinant Monoclonal Antibody (rNX2/294). Confirmation of Purity and Integrity of Antibody.
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PathPlus™ Recombinant Monoclonal Mouse anti‑Human NKX2‑2 Antibody (clone rNX2/294, IHC) LS‑B16255

PathPlus™ Recombinant Monoclonal Mouse anti‑Human NKX2‑2 Antibody (clone rNX2/294, IHC) LS‑B16255

Note: This antibody replaces LS-C751300
Antibody:
NKX2-2 Mouse anti-Human Recombinant Monoclonal (rNX2/294) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$485
LS-B16255-100
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
NKX2-2 Mouse anti-Human Recombinant Monoclonal (rNX2/294) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
NKX2-2 (NK2 homeobox 2) is a homeobox domain nuclear transcription factor involved in the morphogenesis of the central nervous system, including cranial nerves and motor neurons, as well as pancreatic islet cells. It is expressed in various brain regions and within pancreatic islets, and is nuclear in localization. It is useful as a marker to identify well-differentiated neuroendocrine tumors derived from the pancreas and GI tract. References: PlosOne 2015 10.1371/journal.pone.0124408; Development 2010 137(24):4249; Biomark Res 2018 6:15.
Target
Human NKX2-2
Synonyms
NKX2-2 | Homeobox protein Nkx-2.2 | NK-2 (Drosophila) homolog B | NK2 homeobox 2 | NKX2.2 | NKX2B | NK-2 homolog B
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Recombinant Monoclonal
Clone
rNX2/294
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified. Also available Azide-free, Carrier-free.
Immunogen
A full-length human recombinant NKX2.2 protein. Antigen Molecular Weight: 40-50 kDa
Specificity
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
Applications
  • IHC - Paraffin (1:50)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistology (Formalin-fixed - 0.5-1 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About NKX2-2
P42586 NP_035049.1

Validation

NKX2-2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

NKX2-2 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

NKX2-2 Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ NKX2-2 Antibody (clone rNX2/294) for IHC LS-B16255 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/19/2021