NKX2-2 | Homeobox protein Nkx-2.2 | NK-2 (Drosophila) homolog B | NK2 homeobox 2 | NKX2.2 | NKX2B | NK-2 homolog B
(tested or 100% immunogen sequence identity)
Also available Azide-free, Carrier-free
A full-length human recombinant NKX2.2 protein. Antigen Molecular Weight: 40-50 kDa
Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.