Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart Cart lightblue
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Locations


Orders Processing,
Shipping & Receiving,
Warehouse

2 Shaker Rd Suites
B001/B101
Shirley, MA 01464


Production Lab

Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036

Telephone Numbers



Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565

Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Catalog Number Size Price
LS-A2841-50 50 µg (1 mg/ml) $460 
EPHA4 / EPH Receptor A4 Antibody - Anti-EPHA4 antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PathPlus™ Polyclonal Rabbit anti‑Human EPHA4 / EPH Receptor A4 Antibody (Internal, IHC) LS‑A2841

PathPlus™ Polyclonal Rabbit anti‑Human EPHA4 / EPH Receptor A4 Antibody (Internal, IHC) LS‑A2841

Antibody:
EPHA4 / EPH Receptor A4 Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bat, Bovine, Dog, Horse, Pig
Format:
Unconjugated, Unmodified
Price
Catalog Number
$460
LS-A2841-50

Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
EPHA4 / EPH Receptor A4 Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bat, Bovine, Dog, Horse, Pig
Format:
Unconjugated, Unmodified

Specifications

Description
EPHA4 is a receptor tyrosine kinase that binds membrane-bound ephrin to induce bidirectional signaling into neighboring cells. EPHA4 regulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. It plays an important role in the development of the nervous system, controlling different steps of axonal guidance including the establishment of the corticospinal projections. It may also control the segregation of motor and sensory axons during neuromuscular circuit development. It is also involved in synaptic plasticity, injury repair, and angiogenesis in the central nervous system. In amyotrophic lateral sclerosis and other neurodegenerative diseases, EPHA4 plays an important role in the degeneration of neurons and in disease progression, and is a putative therapy target. In immunohistochemistry, EPHA4 has highest cytoplasmic positivity in the brain, and it is also found in the thyroid, respiratory epithelial cells in the lung, reproductive tissues, skin, immune tissues, and at lower levels elsewhere. References: J Neurosci. 2011 Dec 14;31(50):18364-80, PMID: 22171039; J Neurosci. 2007 Dec 19;27(51):14205-15, PMID: 18094260; J Neurochem. 2010 Apr;113(1):153-65; Cell Chem Biol. 2017 Mar 16;24(3):293-305, PMID: 28196613
Target
Human EPHA4 / EPH Receptor A4
Synonyms
EPHA4 | CEK8 | EK8 | Ephrin type-A receptor 4 | HEK8 | SEK | TYRO1 | TYRO1 protein tyrosine kinase | Tyrosine-protein kinase TYRO1 | EPH receptor A4 | EPH-like kinase 8
Host
Rabbit
Reactivity
Human, Monkey, Bat, Bovine, Dog, Horse, Pig (tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Hamster, Rabbit, Xenopus (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 18 amino acid peptide from internal region of human EPHA4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Panda, Bovine, Dog, Bat, Horse, Pig (100%); Mouse, Rat, Hamster, Elephant, Rabbit, Opossum, Platypus, Xenopus (94%); Turkey, Chicken (89%); Lizard (83%).
Epitope
Internal
Specificity
Human EPHA4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (3 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About EPHA4 / EPH Receptor A4
P54764 NM_004438 NP_004429.1

Validation

EPHA4 / EPH Receptor A4 Antibody - Anti-EPHA4 antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EPHA4 antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EPHA4 antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ EPHA4 / EPH Receptor A4 Antibody (Internal) for IHC LS-A2841 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 7/16/2024