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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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EPHA4 / EPH Receptor A4

EPH receptor A4

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

Gene Name: EPH receptor A4
Family/Subfamily: Protein Kinase , Ephrin Receptor
Synonyms: EPHA4, CEK8, EK8, Ephrin type-A receptor 4, HEK8, SEK, TYRO1, TYRO1 protein tyrosine kinase, Tyrosine-protein kinase TYRO1, EPH receptor A4, EPH-like kinase 8
Target Sequences: NM_004438 NP_004429.1 P54764

Filtered by: None
Target
EPHA4 / EPH Receptor A4 (106)
Reactivity
Human (95)
Mouse (49)
Rat (25)
Bat (25)
Bovine (25)
Chicken (5)
Chimpanzee (3)
Dog (26)
Gibbon (3)
Guinea pig (4)
Hamster (14)
Horse (25)
Monkey (32)
Pig (33)
Rabbit (18)
Rhesus monkey (1)
Xenopus (4)
Zebrafish (4)
Application
IHC (63)
IHC-Fr (1)
IHC-P (32)
WB (68)
Flo (8)
ELISA (52)
ICC (6)
IF (10)
IP (8)
Host
rabbit (95)
mouse (11)
Isotype
IgG (40)
IgG1 (2)
IgG1,k (8)
IgG2b (1)
Clonality
monoclonal mc (11)
polyclonal pc (95)
Clone
6C1B6 (1)
6H7 (1)
7D3D4 (2)
Format
AP Conjugated (8)
APC (1)
APC Conjugated (9)
Azide-free (7)
Biotin Conjugated (11)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (11)
HRP Conjugated (11)
PE Conjugated (9)
Unconjugated (45)
Epitope
Internal (22)
C-Terminus (8)
aa40-70 (8)
aa464-492 (8)
aa621-882 (8)
aa875-904 (8)
aa568-617 (4)
aa383-417 (2)
pTyr596 (2)
540-620 aa (1)
Amino Acid: 751-983 (1)
Amino Acid: 777-986 (1)
aa309-342 (1)
aa347 (1)
aa417-451 (1)
Publications
No (106)
Showing 1-25 of 106 results

IHC-plus™ EPHA4 / EPH Receptor A4 Antibody (C-Terminus) LS-A2840
Rabbit Polyclonal to Human EPHA4 / EPH Receptor A4
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
ELISA, IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-EPHA4 antibody IHC of human glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ EPHA4 / EPH Receptor A4 Antibody (Internal) LS-A2839
Rabbit Polyclonal to Human EPHA4 / EPH Receptor A4
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-EPHA4 antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

EPHA4 / EPH Receptor A4 Antibody (aa40-70) LS-C100259
Rabbit Polyclonal to Human EPHA4 / EPH Receptor A4
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Methanol/Acetone fixed human stem cell is used in IF to detect Eph4A (blue) and endothelial Lectin(red). Data kindly provided by Dr. Weis from Cheresh Lab, UCSD.

EPHA4 / EPH Receptor A4 Antibody (C-Terminus) LS-C23105
Mouse Monoclonal (IgG1,k) to Human EPHA4 / EPH Receptor A4
Mouse, Human
ELISA, IHC, IHC-Fr, IP, WB
Unconjugated
100µg  $635.00

EPHA4 / EPH Receptor A4 Antibody (Biotin) LS-C525695
Mouse Monoclonal (IgG1,k) to Human EPHA4 / EPH Receptor A4
Human
ELISA, IHC, IP, WB
Biotin Conjugated
100µl  $800.00

EPHA4 / EPH Receptor A4 Antibody (AP) LS-C507724
Mouse Monoclonal (IgG1,k) to Human EPHA4 / EPH Receptor A4
Human
ELISA, IHC, IP, WB
AP Conjugated
100µl  $800.00

EPHA4 / EPH Receptor A4 Antibody (APC) LS-C516518
Mouse Monoclonal (IgG1,k) to Human EPHA4 / EPH Receptor A4
Human
ELISA, IHC, IP, WB
APC Conjugated
100µl  $800.00

IHC-plus™ EPHA4 / EPH Receptor A4 Antibody (Internal) LS-A2842
Rabbit Polyclonal to Human EPHA4 / EPH Receptor A4
Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-EPHA4 antibody IHC of human glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

EPHA4 / EPH Receptor A4 Antibody LS-C498789
Rabbit Polyclonal (IgG) to Human EPHA4 / EPH Receptor A4
Human
ELISA, IF, IHC
Unconjugated
50µg 4mg/ml  $285.00; 100µg 4mg/ml  $385.00
Immunohistochemistry of paraffin-embedded human spleen tissue using EPHA4 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using EPHA4 Antibody at dilution of 1:100

IHC-plus™ EPHA4 / EPH Receptor A4 Antibody (Internal) LS-A2841
Rabbit Polyclonal to Human EPHA4 / EPH Receptor A4
Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-EPHA4 antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

EPHA4 / EPH Receptor A4 Antibody (aa464-492) LS-C329511
Rabbit Polyclonal (IgG) to Mouse EPHA4 / EPH Receptor A4
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00

EPHA4 / EPH Receptor A4 Antibody (aa40-70) LS-C330427
Rabbit Polyclonal (IgG) to Human EPHA4 / EPH Receptor A4
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200µl  $590.00

EPHA4 / EPH Receptor A4 Antibody (aa40-70, Biotin) LS-C225355
Rabbit Polyclonal (IgG) to Human EPHA4 / EPH Receptor A4
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200µl  $740.00

EPHA4 / EPH Receptor A4 Antibody (aa40-70, FITC) LS-C225357
Rabbit Polyclonal (IgG) to Human EPHA4 / EPH Receptor A4
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200µl  $740.00

EPHA4 / EPH Receptor A4 Antibody (aa40-70, AP) LS-C225354
Rabbit Polyclonal (IgG) to Human EPHA4 / EPH Receptor A4
Human
ELISA, Flo, ICC, IF, IHC, WB
AP Conjugated
200µl  $740.00

EPHA4 / EPH Receptor A4 Antibody (aa40-70, APC) LS-C225356
Rabbit Polyclonal (IgG) to Human EPHA4 / EPH Receptor A4
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200µl  $740.00

EPHA4 / EPH Receptor A4 Antibody (aa40-70, Azide-free, HRP) LS-C225358
Rabbit Polyclonal (IgG) to Human EPHA4 / EPH Receptor A4
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

EPHA4 / EPH Receptor A4 Antibody (aa40-70, PE) LS-C225359
Rabbit Polyclonal (IgG) to Human EPHA4 / EPH Receptor A4
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200µl  $740.00

EPHA4 / EPH Receptor A4 Antibody (aa309-342) LS-C344374
Rabbit Polyclonal to Human EPHA4 / EPH Receptor A4
Mouse, Human
WB
Unconjugated
400µl  $325.00
Western blot of lysates from HeLa cell line and mouse lung tissue lysate (from left to right) with Mouse Epha4 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.

EPHA4 / EPH Receptor A4 Antibody (aa464-492) LS-C164375
Rabbit Polyclonal to Human EPHA4 / EPH Receptor A4
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Mouse Epha4 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded mouse cerebellum tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Mouse Epha4 Antibody western blot of K562 cell line lysates (35 ug/lane). The Epha4 antibody detected the Epha4 protein (arrow).

EPHA4 / EPH Receptor A4 Antibody (clone 6H7) LS-C197143
Mouse Monoclonal [clone 6H7] (IgG1,k) to Human EPHA4 / EPH Receptor A4
Mouse, Human
ELISA, WB
Unconjugated
100µg  $365.00
EPHA4 monoclonal antibody (M02), clone 6H7 Western Blot analysis of EPHA4 expression in NIH/3T3.
Detection limit for recombinant GST tagged EPHA4 is approximately 0.1 ng/ml as a capture antibody.

EPHA4 / EPH Receptor A4 Antibody (540-620 aa) LS-C381105
Rabbit Polyclonal (IgG) to Human EPHA4 / EPH Receptor A4
Mouse, Human
ELISA, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Phospho-EphA4 (Y596) antibody

EPHA4 / EPH Receptor A4 Antibody (aa621-882) LS-C374806
Rabbit Polyclonal to Human EPHA4 / EPH Receptor A4
Pig, Human
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00
Western blot of EPHA4 / EPH Receptor A4 antibody.
Western Blot; Sample: Porcine Cerebrum lysate; Primary Ab: 1µg/ml Rabbit Anti-Human EPHA4 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody

EPHA4 / EPH Receptor A4 Antibody LS-C665378
Rabbit Polyclonal (IgG) to Human EPHA4 / EPH Receptor A4
Human
ELISA, IF, IP, WB
Unconjugated
100µg  $355.00

EPHA4 / EPH Receptor A4 Antibody (aa875-904) LS-C100260
Rabbit Polyclonal to Human EPHA4 / EPH Receptor A4
Human
IHC, IHC-P, WB
Unconjugated
200µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of lysates from HeLa, HUVEC cell line (from left to right), using EPHA4 Antibody (R890). Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
Showing 1-25 of 106 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).