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Catalog Number Size Price
LS-B16288-100 100 µg (0.2 mg/ml) $495 
EPCAM Antibody - Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
EPCAM Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
EPCAM Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
EPCAM Antibody - SDS-PAGE Analysis Purified EpCAM Rabbit Recombinant Monoclonal Antibody (EGP40/1556R). Confirmation of Purity and Integrity of Antibody.
EPCAM Antibody - Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
EPCAM Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
EPCAM Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
EPCAM Antibody - SDS-PAGE Analysis Purified EpCAM Rabbit Recombinant Monoclonal Antibody (EGP40/1556R). Confirmation of Purity and Integrity of Antibody.
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PathPlus™ Recombinant Monoclonal Rabbit anti‑Human EPCAM Antibody (clone EGP40/1556R, IHC, IF) LS‑B16288

PathPlus™ Recombinant Monoclonal Rabbit anti‑Human EPCAM Antibody (clone EGP40/1556R, IHC, IF) LS‑B16288

Note: This antibody replaces LS-C751261
Antibody:
EPCAM Rabbit anti-Human Recombinant Monoclonal (EGP40/1556R) Antibody
Application:
IHC-P, IF, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$495
LS-B16288-100
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
EPCAM Rabbit anti-Human Recombinant Monoclonal (EGP40/1556R) Antibody
Application:
IHC-P, IF, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
EPCAM (TACSTD1) is an epithelial membrane glycoprotein involved in cell adhesion that is present on the surface of a variety of epithelial cells. It is expressed in a wide variety of cancers, including: basal cell carcinomas, mammary Paget disease, lung adenocarcinomas, trichoepitheliomas, dermatofibromas, basal-cell carcinomas, cholangiocarcinomas, colorectal carcinomas, and carcinomas of prostate, ovary, endometrium, head and neck, and thyroid. EPCAM is useful for distinguishing epithelial cells (positive) from mesothelial cells (negative). It has also been implicated in the progression of individuals with Lynch Syndrome who hold inherited deletions in the gene. These deletions lead to silencing of the adjacent repair gene MSH2 via transcriptional read-through, which then causes microsatellite instability and colorectal cancer (as well as other malignancies that also frequently arise from Lynch Syndrome). MOC31 and BerEP4 are common monoclonal antibodies to this target. References: JClinPathol 1990,43:213; Acta Neuropathol 1991, 83:46; Dai, 2017; Baeuerle, 2007; Kempers 2010; ModPath 2002, 15:1279
Target
Human EPCAM
Synonyms
EPCAM | 323/A3 | ACSTD1 | 17-1A | CD326 | EGP | EGP34 | Epithelial glycoprotein | GA733-2 | HNPCC8 | Ep-CAM | ESA | HEGP314 | KS 1/4 antigen | KS1/4 | KSA | M1S2 | MIC18 | MK-1 | MH99 | TROP1 | TACST-1 | TACSTD1 | CD326 antigen | CO-17A | DIAR5 | EGP-2 | EGP314 | EGP40 | Epithelial glycoprotein 314 | HEA125 | Ly74 | M4S1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Non-Reactivity
Mouse, Rat
Clonality
IgG Recombinant Monoclonal
Clone
EGP40/1556R
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified. Also available Azide-free, Carrier-free.
Immunogen
Recombinant full-length human TACSTD1 protein. Antigen Molecular Weight: 40-43 kDa
Specificity
EGP40 is a 40-43 kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (EpCAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas with the exception of adult squamous epithelium, hepatocytes and gastric epithelial cells. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. This antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma.
Applications
  • IHC - Paraffin (1:100)
  • Immunofluorescence (1 - 2 µg/ml)
  • Flow Cytometry (1 - 2 µg/10E6 cells)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistology (Formalin-fixed - 0.5-1 ug/ml for 30 min at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About EPCAM
P16422 NM_002354 NP_002345.2

Validation

EPCAM Antibody - Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

EPCAM Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

EPCAM Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ EPCAM Antibody (clone EGP40/1556R) for IHC, IF/Immunofluorescence, Flow LS-B16288 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 7/4/2022