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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16145-100 | 100 µl (1 mg/ml) | $460 |
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PathPlus™ Monoclonal Mouse anti‑Human CLDN18 / Claudin 18 Antibody (IHC) LS‑B16145
PathPlus™ Monoclonal Mouse anti‑Human CLDN18 / Claudin 18 Antibody (IHC) LS‑B16145
Note: This antibody replaces LS-C744501
Antibody:
CLDN18 / Claudin 18 Mouse anti-Human Monoclonal Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
CLDN18 / Claudin 18 Mouse anti-Human Monoclonal Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
CLDN18/claudin 18 is a member of the claudin family of integral membrane proteins that comprise tight junction strands. These are formed at points of cell-cell adhesion at the plasma membrane in epithelial cells. There are two splice variants, one expressed in the gastric mucosa and the other in lung. The gastric isoform is expressed in gastric tumors as well as tumors of other tissues, including the lung, ovary, pancreas, and esophagus. Staining is used to identify gastrointestinal and pancreatobiliary neoplasms such as gastrointestinal signet ring cell carcinoma, pancreatic ductal adenocarcinomas, and intrahepatic cholangiocarcinoma.
References: Mol Cell Biol. 2001;21(21):7380-7390. doi: 10.1128/MCB.21.21.7380-7390.2001; Clin Cancer Res. 2008;14(23):7624-7634. doi: 10.1158/1078-0432.CCR-08-1547; Gene. 2011;481(2):83-92. doi: 10.1016/j.gene.2011.04.007; Am J Surg Pathol. 2008;32(8):1182-1189. doi: 10.1097/PAS.0b013e318163a8f8; J Histochem Cytochem. 2011;59(10):942-952. doi: 10.1369/0022155411420569; Virchows Arch. 2011;459(1):73-80. doi: 10.1007/s00428-011-1092-z.
Target
Human CLDN18 / Claudin 18
Synonyms
CLDN18 | Claudin 18 | Claudin-18 | SFTPJ | SFTA5 | Surfactant associated 5
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Monoclonal
Conjugations
Unconjugated
Purification
Immunogen affinity purified
Modifications
Unmodified
Immunogen
Synthetic Claudin 18
Applications
- IHC (1:200 - 1:400)
- IHC - Paraffin (1:50)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Use Heat-induced epitope retrieval (HIER) Citrate buffer of pH 6.0 Recommended IHC controls tissues are Stomach. Resulting localization is Membranous
Presentation
PBS, pH7.4, 50% glycerol, 0.03% Proclin300
Storage
Store at -20°C for up to 1 year.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CLDN18 / Claudin 18
Validation
Human Stomach: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Stomach: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Stomach: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Stomach: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ CLDN18 / Claudin 18 Antibody for IHC LS-B16145 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, Immunoprecipitation, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, ELISA
Species:
Human
Applications:
IHC, Western blot, Immunoprecipitation, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, ELISA
Reactivity:
Human
Range:
0.313-20 ng/ml
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 5/13/2024
Date Requested: 5/13/2024
