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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-B7045-50 50 µl (1 mg/ml) $425 
PARK2 / Parkin 2 Antibody - Anti-PARK2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
PARK2 / Parkin 2 Antibody - Western blot analysis of lysates from Jurkat cells, using Parkin Antibody. The lane on the right is blocked with the synthesized peptide.
PARK2 / Parkin 2 Antibody - Anti-PARK2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
PARK2 / Parkin 2 Antibody - Western blot analysis of lysates from Jurkat cells, using Parkin Antibody. The lane on the right is blocked with the synthesized peptide.
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PathPlus™ Polyclonal Rabbit anti‑Human PARK2 / Parkin 2 Antibody (aa1‑50, IHC, WB) LS‑B7045

PathPlus™ Polyclonal Rabbit anti‑Human PARK2 / Parkin 2 Antibody (aa1‑50, IHC, WB) LS‑B7045

Note: This antibody replaces LS-C118549
Antibody:
Rabbit Polyclonal to Human PARK2 / Parkin 2
Application:
IHC, IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B7045-50
50 µl
1 mg/ml
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human PARK2 / Parkin 2
Application:
IHC, IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified

Specifications

Description
PRKN (Parkin, PARK2) is an E3 ubiquitin ligase involved in ubiquitination, the promotion of cell survival, autophagy and mitophagy. Mutations in PRKN result in mitochondrial dysfunction and are thought to lead to juvenile and early-onset Parkinson disease (AR-JP). Additionally, PRKN mutations, loss of function or loss of expression events are frequent in glioblastoma, lung cancers and other malignancies and are correlated with worse prognosis. In immunohistochemistry, PRKN has high cytoplasmic and nuclear positivity in the brain, and is also expressed in other tissues including the kidney, testes, muscle, lung, gastrointestinal tract, liver, and thyroid and adrenal glands. References: The FEBS Journal. 282 (11): 2076–88, PMID: 25712550; Nature Genetics. 42 (1): 77–82, PMID: 19946270;
Target
Human PARK2 / Parkin 2
Synonyms
PARK2 | AR-JP | LPRS2 | Parkin | PDJ | Parkinson disease protein 2 | PRKN | PRKN2
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:100)
  • Western blot (1:500 - 1:1000)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:5000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide from human Parkin. (AA Range: 1-50)
Epitope
aa1-50
Specificity
Parkin Antibody detects endogenous levels of total Parkin protein.
Usage
Western Blot: Predicted MW 51 kDa
Presentation
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide, 50% Glycerol
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About PARK2 / Parkin 2
O60260 NM_004562 NP_004553.2

Validation

PARK2 / Parkin 2 Antibody - Anti-PARK2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-PARK2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-PARK2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

LSBio Ratings

PathPlus™ PARK2 / Parkin 2 Antibody (aa1-50) for IHC, WB/Western LS-B7045 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 7/15/2020