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PathPlusTM PARK2 / Parkin 2 Antibodies
PRKN (Parkin, PARK2) is an E3 ubiquitin ligase involved in ubiquitination, the promotion of cell survival, autophagy and mitophagy. Mutations in PRKN result in mitochondrial dysfunction and are thought to lead to juvenile and early-onset Parkinson disease (AR-JP). Additionally, PRKN mutations, loss of function or loss of expression events are frequent in glioblastoma, lung cancers and other malignancies and are correlated with worse prognosis. In immunohistochemistry, PRKN has high cytoplasmic and nuclear positivity in the brain, and is also expressed in other tissues including the kidney, testes, muscle, lung, gastrointestinal tract, liver, and thyroid and adrenal glands. References: The FEBS Journal. 282 (11): 2076–88, PMID: 25712550; Nature Genetics. 42 (1): 77–82, PMID: 19946270;

2 PathPlusTM Antibodies
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Antibodies (2)
Primary (2)
PARK2 / Parkin 2 (2)
Human (2)
Mouse (2)
Rat (2)
IHC (2)
IHC-P (2)
WB (2)
IF (1)
Peptide-ELISA (1)
rabbit (2)
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polyclonal pc (2)
Unconjugated (2)
aa1-50 (1)
No (2)
PARK2 / Parkin 2 Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
PARK2 / Parkin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
PARK2 / Parkin 2 Antibody - Anti-PARK2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Neuroscience
PARK2 / Parkin 2 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
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