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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A1895-50 50 µg (1 mg/ml) $425 
LPAR4 / GPR23 Antibody - Anti-LPAR4 / GPR23 antibody IHC of human brain neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LPAR4 / GPR23 Antibody - Ovary, Carcinoma
LPAR4 / GPR23 Antibody - Anti-LPAR4 / GPR23 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LPAR4 / GPR23 Antibody - Anti-LPAR4 / GPR23 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LPAR4 / GPR23 Antibody - Anti-LPAR4 / GPR23 antibody IHC of human brain neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LPAR4 / GPR23 Antibody - Ovary, Carcinoma
LPAR4 / GPR23 Antibody - Anti-LPAR4 / GPR23 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LPAR4 / GPR23 Antibody - Anti-LPAR4 / GPR23 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human LPAR4 / GPR23 Antibody (N‑Terminus, IHC) LS‑A1895

PathPlus™ Polyclonal Rabbit anti‑Human LPAR4 / GPR23 Antibody (N‑Terminus, IHC) LS‑A1895

Antibody:
Rabbit Polyclonal to Human LPAR4 / GPR23
Application:
IHC, IHC-P, Flo
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Hamster
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A1895-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human LPAR4 / GPR23
Application:
IHC, IHC-P, Flo
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Hamster
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Lysophosphatidic acid receptor 4 (LPAR4) is a mediator of diverse cellular activities. It transduces signals by increasing intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA. LPAR4 has highest membranous positivity in the hippocampus, corpus callosum, thalamus and amygdala in the brain, and it is also found throughout the central nervous system, on granulocytes, in the ovaries, and at low levels in various tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human LPAR4 / GPR23
Synonyms
LPAR4 | G-protein coupled receptor 23 | LPA-4 | p2RY9 | p2Y5-LIKE | p2Y purinoceptor 9 | p2Y5-like receptor | p2Y9 | G protein-coupled receptor 23 | GPR23 | LPA receptor 4 | LPA4 | Purinergic receptor 9
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat, Hamster (tested or 100% immunogen sequence identity)
Predicted
Bovine, Dog, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (2 µg/ml)
  • Flow Cytometry
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 19 amino acid peptide from N-Terminus extracellular domain of human LPAR4 / GPR23. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bat, Hamster (100%); Dog, Bovine, Elephant, Panda, Rabbit, Horse, Pig (95%).
Blocking Peptide
LS-E28425 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A1895. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
N-Terminus
Specificity
Human LPAR4 / GPR23. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About LPAR4 / GPR23
Q99677 NM_005296 NP_005287.1

Validation

LPAR4 / GPR23 Antibody - Anti-LPAR4 / GPR23 antibody IHC of human brain neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LPAR4 / GPR23 antibody IHC of human brain neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LPAR4 / GPR23 antibody IHC of human brain neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LPAR4 / GPR23 Antibody - Ovary, Carcinoma
Ovary, Carcinoma
Ovary, Carcinoma

LPAR4 / GPR23 Antibody - Anti-LPAR4 / GPR23 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LPAR4 / GPR23 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LPAR4 / GPR23 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LPAR4 / GPR23 Antibody - Anti-LPAR4 / GPR23 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LPAR4 / GPR23 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LPAR4 / GPR23 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ LPAR4 / GPR23 Antibody (N-Terminus) for IHC, Flow LS-A1895 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells. Lin DA, Boyce JA. Journal of immunology (Baltimore, Md. : 1950). 2005 175:5430-8. (Flo; Human)

Customer Reviews (0)


Requested From: United States
Date Requested: 6/1/2020