Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
LPAR4 / GPR23
lysophosphatidic acid receptor 4
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.
IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells. Lin DA, Boyce JA. Journal of immunology (Baltimore, Md. : 1950). 2005 175:5430-8. (Flo; Human)
Related Antibodies: LS-A1895.
Elevated plasma levels of lysophosphatidic acid and aberrant expression of lysophosphatidic acid receptors in adenomyosis. Yang B, Wang L, Wan X, Li Y, Yu X, Qin Y, Luo Y, Wang F, Huang O. BMC women's health. 2017 November;17:118. (Human)[Full Text Article]
Related Antibodies: LS-A872.