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Catalog Number Size Price
LS-B3203-0.05 0.05 mg (1 mg/ml) $425 
BECN1 / Beclin-1 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
BECN1 / Beclin-1 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
BECN1 / Beclin-1 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
BECN1 / Beclin-1 Antibody - Anti-BECN1 / Beclin-1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
BECN1 / Beclin-1 Antibody - Anti-BECN1 / Beclin-1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
BECN1 / Beclin-1 Antibody - Anti-BECN1 / Beclin-1 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
BECN1 / Beclin-1 Antibody - Immunofluorescence of Beclin-1 in human brain tissue with Beclin-1 antibody at 20 µg/ml.
BECN1 / Beclin-1 Antibody - Immunofluorescence of Beclin-1 in mouse brain tissue with Beclin-1 antibody at 20 µg/ml.Green: Beclin-1 Antibody  Blue: DAPI staining
BECN1 / Beclin-1 Antibody - Western blot of Beclin-1 in 293 cell lysate with Beclin-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
BECN1 / Beclin-1 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
BECN1 / Beclin-1 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
BECN1 / Beclin-1 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
BECN1 / Beclin-1 Antibody - Anti-BECN1 / Beclin-1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
BECN1 / Beclin-1 Antibody - Anti-BECN1 / Beclin-1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
BECN1 / Beclin-1 Antibody - Anti-BECN1 / Beclin-1 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
BECN1 / Beclin-1 Antibody - Immunofluorescence of Beclin-1 in human brain tissue with Beclin-1 antibody at 20 µg/ml.
BECN1 / Beclin-1 Antibody - Immunofluorescence of Beclin-1 in mouse brain tissue with Beclin-1 antibody at 20 µg/ml.Green: Beclin-1 Antibody  Blue: DAPI staining
BECN1 / Beclin-1 Antibody - Western blot of Beclin-1 in 293 cell lysate with Beclin-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
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PathPlus™ Polyclonal BECN1 / Beclin‑1 Antibody (IHC, IF, WB) LS‑B3203

PathPlus™ Polyclonal BECN1 / Beclin‑1 Antibody (IHC, IF, WB) LS‑B3203

Note: This antibody replaces LS-C19537, LS-C56772, LS-C42329
Antibody:
Rabbit Polyclonal to Human BECN1 / Beclin-1
Application:
IHC-P, ICC, IF, WB, ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B3203-0.05
0.05 mg
1 mg/ml
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human BECN1 / Beclin-1
Application:
IHC-P, ICC, IF, WB, ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified

Specifications

Description
BECN1 (Beclin 1) is a coiled coil protein that interacts with prototypic cellular anti-apoptotic gene BCL2 and modulates autophagy and cell death. BECN1 is widely expressed with highest levels in skeletal muscle. In schizophrenia, increased neuronal cell death is caused by lowered levels of BECN1 in the hippocampus. Additionally, allelic deletion of BECN1 results in a wide variety of cancers including breast cancer. In immunohistochemistry, BECN1 has cytoplasmic positivity in a majority of tissues throughout the body. References: Molecular Psychiatry. 20 (1): 126–32, PMID: 24365867; The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804;
Target
Human BECN1 / Beclin-1
Synonyms
BECN1 | ATG6 | Beclin 1 | Beclin 1, autophagy related | Beclin1 | GT197 | Protein GT197 | VPS30 | Beclin-1
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Peptide Column Affinity Chromatography
Modifications
Unmodified
Applications
  • IHC - Paraffin (5 µg/ml)
  • ICC
  • Immunofluorescence
  • Western blot (0.5 - 1 µg/ml)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
A 17 AA synthetic peptide near the N-Terminus of human Beclin-1. The immunogen is located within aa 40-90 of Beclin-1.
Blocking Peptide
LS-E30178 - Liquid - 0.05 mg 200 µg/ml - $145.00
Immunizing peptide used to generate LS-B3203. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Usage
Beclin-1 antibody can be used for the detection of Beclin-1 by Western blot at 0.5 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2 ug/mL. For immunofluorescence start at 20 ug/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human, mouse, and rat samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested. Western Blot:
Presentation
PBS containing 0.02% Sodium Azide
Storage
Store at 4°C for up 3 months. Store at -20°C for up to 1 year. Avoid freeze/thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About BECN1 / Beclin-1
Q14457 NM_003766 NP_003757.1

Validation

BECN1 / Beclin-1 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

BECN1 / Beclin-1 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

BECN1 / Beclin-1 Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)

BECN1 / Beclin-1 Antibody - Anti-BECN1 / Beclin-1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-BECN1 / Beclin-1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-BECN1 / Beclin-1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

BECN1 / Beclin-1 Antibody - Anti-BECN1 / Beclin-1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-BECN1 / Beclin-1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-BECN1 / Beclin-1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

BECN1 / Beclin-1 Antibody - Anti-BECN1 / Beclin-1 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-BECN1 / Beclin-1 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-BECN1 / Beclin-1 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

LSBio Ratings

PathPlus™ BECN1 / Beclin-1 Antibody for IHC, ICC, IF/Immunofluorescence, WB/Western, ELISA LS-B3203 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 3/29/2020