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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-B439-0.05 0.05 mg (1 mg/ml) $545 
ACE2 / ACE-2 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
ACE2 / ACE-2 Antibody - Immunofluorescence of ACE2 in Human Kidney cells with ACE2 antibody at 20 ug/ml.
ACE2 / ACE-2 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
ACE2 / ACE-2 Antibody - Immunofluorescence of ACE2 in Human Kidney cells with ACE2 antibody at 20 ug/ml.
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PathPlus™ Polyclonal Rabbit anti‑Human ACE2 / ACE‑2 Antibody (IHC, IF, WB) LS‑B439

PathPlus™ Polyclonal Rabbit anti‑Human ACE2 / ACE‑2 Antibody (IHC, IF, WB) LS‑B439

Note: This antibody replaces LS-C346, LS-C69026, LS-C69021, LS-C56853
Antibody:
ACE2 / ACE-2 Rabbit anti-Human Polyclonal Antibody
Application:
IHC-P, IF, WB, ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Price
Catalog Number
$545
LS-B439-0.05
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
ACE2 / ACE-2 Rabbit anti-Human Polyclonal Antibody
Application:
IHC-P, IF, WB, ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified

Specifications

Description
Angiotensin-Converting Enzyme 2 (ACE2) is a transmembrane protein found in the lungs, intestines, heart, kidney, liver and arteries that plays a central role in vascular, renal, and myocardial physiology. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7. It is involved in controlling vascular function including blood pressure, and absence of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE2 is also the primary attachment receptor for HCoV-N63, SARS-CoV and SARS-CoV-2. The S1 portion of the coronavirus spike protein attaches to ACE2 presented on the host cell surface. The SARS-CoV-2 virus targets pneumocytes and macrophages expressing ACE2 in the lung, and it is believed to infect ACE2-positive cells in other tissues including the gastrointestinal tract and potentially the liver (in cholangiocytes). Hoffmann et al., 2020, Cell. 181, 1–10. April 16, 2020, DOI: 10.1016/j.cell.2020.02.052; Zhou, P et al. Nature.579, 270–273 (2020). DOI: 10.1038/s41586-020-2012-7; Xiaoqiang Chai et al. bioRxiv 2020.02.03.931766, DOI: 10.1101/2020.02.03.931766; Tikellis, Chris, and M C Thomas. Int J Pep. vol. 2012 (2012): 256294. doi:10.1155/2012/256294; Wrap et al. Science, 13 Mar 2020:Vol. 367, Issue 6483, pp. 1260-1263. DOI: 10.1126/science.abb2507;
Target
Human ACE2 / ACE-2
Synonyms
ACE2 | ACE-related carboxypeptidase | ACEH | Metalloprotease MPROT15 | SARS-CoV2 Coronavirus Receptor | SARS-CoV-2 Coronavirus Receptor | COVID-19 viral receptor
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Peptide Column Affinity Chromatography
Modifications
Unmodified
Immunogen
A synthetic peptide corresponding to amino acids near the center of human ACE2. The immunogen is located within aa 180-230 of ACE2.
Blocking Peptide
LS-E30041 - Liquid - 0.05 mg 200 µg/ml - $145.00
Immunizing peptide used to generate LS-B439. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Specificity
Anti-ACE2 has no cross response to ACE1.
Applications
  • IHC - Paraffin (2.5 µg/ml)
  • Immunofluorescence
  • Western blot (0.5 - 2 µg/ml)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
ACE2 antibody can be used for the detection of ACE2 by Western blot at 0.5 to 2 ug/mL. A 90 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 2 ug/mL. For immunofluorescence start at 20 ug/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Western Blot:
Presentation
PBS containing 0.02% Sodium Azide
Storage
Store at 4°C for up 3 months. Store at -20°C for up to 1 year. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ACE2 / ACE-2
Q9BYF1 NM_021804 NP_068576.1

Validation

ACE2 / ACE-2 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)

ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

LSBio Ratings

PathPlus™ ACE2 / ACE-2 Antibody for IHC, IF/Immunofluorescence, WB/Western, ELISA LS-B439 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 10/27/2020