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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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ACE2 / ACE-2

angiotensin I converting enzyme 2

Angiotensin-Converting Enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE2 is also the attachment receptor for HCoV-N63, SARS-CoV and SARS-CoV-2. The S1 portion of the coronavirus spike protein attaches to ACE2 presented on the host cell surface. The SARS-CoV-2 virus targets pneumocytes and macrophages expressing ACE2 in the lung, and it is believed to infect ACE2-positive cells in other tissues including the gastrointestinal tract and potentially the liver (in cholangiocytes).

Gene Name: angiotensin I converting enzyme 2
Family/Subfamily: Protease , Metallopeptidase M2
Synonyms: ACE2, ACE-related carboxypeptidase, ACEH, Metalloprotease MPROT15, SARS-CoV2 Coronavirus Receptor, SARS-CoV-2 Coronavirus Receptor, COVID-19 viral receptor
Target Sequences: NM_021804 NP_068576.1 Q9BYF1

Publications (2)

1
Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. Adedeji AO, Severson W, Jonsson C, Singh K, Weiss SR, Sarafianos SG. Journal of virology. 2013 87:8017-28. (IHC; Human) [Full Text Article] [PubMed:23678171] [PMC:PMC3700180] Related Antibodies: LS-C122669.
2
Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice. Chhabra KH, Xia H, Pedersen KB, Speth RC, Lazartigues E. American journal of physiology. Endocrinology and metabolism. 2013 Apr;304:E874-84. [Full Text Article] [PubMed:23462816] [PMC:PMC3625779] Related Antibodies: LS-B3197.


ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human ACE2 / ACE-2
Human
ELISA, IF, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $545.00
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human ACE2 / ACE-2
Mouse, Human
ELISA, IF, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal to Human ACE2 / ACE-2
Human
IHC-P, WB
Unconjugated
200µl   $425.00
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human ACE2 / ACE-2
Pig, Human
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $485.00
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human ACE2 / ACE-2
Pig, Orangutan, Gibbon, Human
IHC, IHC-P, WB
HRP Conjugated
100µl   $405.00
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human ACE2 / ACE-2
Pig, Orangutan, Gibbon, Human
IHC, IHC-P, WB
FITC Conjugated
100µl   0.5mg/ml   $405.00
ACE2 / ACE-2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone 1G4] (IgG1) to Human ACE2 / ACE-2
Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
ACE2 / ACE-2 Antibody - Anti-ACE-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human ACE2 / ACE-2
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
ACE2 / ACE-2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone AC18F] (IgG1,k) to Human ACE2 / ACE-2
Human
ELISA, Flo, IHC-P, WB
Unconjugated
50µg   1mg/ml   $275.00; 100µg   1mg/ml   $325.00
ACE2 / ACE-2 Antibody - Western blot analysis using anti-ACE2 (human), mAb (AC18F) at 1: 2,000 dilution. 1. hACE2 (Fc protein). 2. hACE2 (Ecto domain) (FLAG-tagged). 3. Other hGITR (Fc protein) (control).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone AC18F] (IgG1,k) to Human ACE2 / ACE-2
Human
ELISA, Flo, WB
Biotin Conjugated
50µg   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Human ACE2 / ACE-2
Human
ELISA, Flo, IHC, WB
Unconjugated
200µl   2.24mg/ml   $590.00
Select
Rabbit Polyclonal (IgG) to Human ACE2 / ACE-2
Human
ELISA, IHC, WB
FITC Conjugated
200µl   0.5mg/ml   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACE2 / ACE-2
Human
ELISA, Flo, IHC, WB
APC Conjugated
200µl   0.5mg/ml   $740.00
Select
Rabbit Polyclonal (IgG) to Human ACE2 / ACE-2
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   0.5mg/ml   $740.00
Select
Goat Polyclonal (IgG) to Human ACE2 / ACE-2
Human
ELISA, IHC, IP, WB
Unconjugated
100µg   $785.00
Select
Rabbit Polyclonal (IgG) to Human ACE2 / ACE-2
Human
ELISA, IHC, WB
Unconjugated
200µl   1.62mg/ml   $590.00
Select
Rabbit Polyclonal (IgG) to Human ACE2 / ACE-2
Human
ELISA, IHC, WB
PE Conjugated
200µl   0.45mg/ml   $740.00
ACE2 / ACE-2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal to Human ACE2 / ACE-2
Human
IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Mouse ACE2 / ACE-2
Mouse
ELISA, WB
Unconjugated
100µg   $755.00
Select
Mouse Monoclonal (IgG2a) to Human ACE2 / ACE-2
Human
ELISA, WB
Unconjugated
100µg   $755.00
Select
Rabbit Polyclonal (IgG) to Mouse ACE2 / ACE-2
Mouse, Rat, Human
WB
Unconjugated
60µl   330µg/ml   $235.00; 120µl   0.33mg/ml   $295.00; 200µl   330µg/ml   $395.00
ACE2 / ACE-2 Antibody - IHC of human kidney tissue using ACE2 antibody at 2 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human ACE2 / ACE-2
Human
ELISA, IF, IHC, WB
Unconjugated
0.1mg   1mg/ml   $375.00
ACE2 / ACE-2 Antibody - Western blot analysis of ACE2 expression in HeLa (A); SP20 (B); PC12 (C) whole cell lysates.
Select
Rabbit Polyclonal to Human ACE2 / ACE-2
Mouse, Rat, Human
WB
Unconjugated
100µl   1mg/ml   $275.00
ACE2 / ACE-2 Antibody - Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ACE2 antibody. Counterstained with hematoxylin.
Select
Rabbit Recombinant Monoclonal [clone SN0754] (IgG) to Human ACE2 / ACE-2
Mouse, Rat, Hamster, Human
ICC, IHC, IP, WB
Unconjugated
50µl   1mg/ml   $275.00; 100µl   1mg/ml   $325.00
ACE2 / ACE-2 Antibody - Immunohistochemistry of paraffin-embedded human gastric cancer at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human ACE2 / ACE-2
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50µg   $285.00; 100µg   $385.00
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).