LSBio offers more than 1000 specific antibodies to G Protein-Coupled Receptors (GPCRs). Antibodies to this challenging group of transmembrane targets were generated by targeting unique peptide epitopes in the amino, carboxy, and extracellular or intracellular loops of these transmembrane proteins and synthesizing multiple antibodies to each GPCR. The resulting polyclonal antibodies were extensively validated, compared across different antibodies to each target, and only the antibodies showing the greatest specificity were offered for sale. In addition, antibodies to the most popular 340 targets were used in IHC to generate comprehensive localization reports across a broad panel of normal and diseased human tissue types.