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WFDC2 / HE4 is a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
Gene Name: | WAP four-disulfide core domain 2 |
Synonyms: | WFDC2, Epididymis-specific he4, Epididymal protein 4, DJ461P17.6, EDDM4, HE4, WAP5 |
Target Sequences: | NM_006103 NP_006094.3 Q14508 |
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