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SLC5A5 / NIS is a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.
Gene Name: | solute carrier family 5 (sodium/iodide cotransporter), member 5 |
Family/Subfamily: | Transporter , Solute:sodium symporter |
Synonyms: | SLC5A5, Sodium-iodide symporter, Na(+)/I(-) cotransporter, NIS, Sodium/iodide cotransporter, Na(+)/I(-) symporter, Na+/I- symporter, TDH1 |
Target Sequences: | NM_000453 NP_000444.1 Q92911 |
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