Human PTPN11 / SHP-2 / NS1

Rabbit

Human, Mouse, Rat, Guinea pig, Hamster, Horse, Chicken (tested or 100% immunogen sequence identity)

Bat, Bovine, Dog, Pig, Rabbit, Sheep (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide from the C-Terminus of human SHP2 (EDSARVYENVGLMQQ, aa578-592 of UniProt Q06124). Percent identity by BLAST analysis: Human, Mouse, Rat, Hamster, Horse, Guinea pig, Zebra finch, Chicken (100%); Ferret, Sheep, Cat, Bovine, Bat, Elephant, Rabbit, Pig, Opossum, Platypus, Lizard, Trout, Pufferfish, Stickleback, Dog (93%); Xenopus, Catfish, Zebrafish (87%).

aa578-592

Human PTPN11 / SHP-2 / NS1.

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

The tyrosine phosphatase SHP2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific phosphotyrosine motifs, concurrent with its re-localization and stimulation of phosphatase activity. It can potentiate signalling through the MAP-kinase pathway and is required during early mouse development for gastrulation. SHP2 is specifically required in mesenchyme cells of the progress zone (PZ), directly beneath the distal ectoderm of the limb bud. Rather than integrating proliferative signals, it probably exerts its effects on limb development by influencing cell shape, movement or adhesion. Furthermore, the branchial arches, which also use Fgfs during bud outgrowth, similarly require Shp2. Thus, it regulates phosphotyrosine-signalling events during the complex ectodermal-mesenchymal interactions that regulate mammalian budding morphogenesis.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q06124 NCBI: NM_002834 NP_002825.3