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PTPN11 / SHP-2 / NS1

protein tyrosine phosphatase, non-receptor type 11

PTPN11 / SHP-2 / NS1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: protein tyrosine phosphatase, non-receptor type 11
Family/Subfamily: Protein Phosphatase , NT2
Synonyms: PTPN11, Bptp-3, BPTP3, CFC, Csw, Corkscrew csw, Gene corkscrew, Phosphatase corkscrew, PTP-2C, SHP2, PTP-1D, PTP2C, SHP-2, SHPTP2, Noonan syndrome 1, SH-PTP2, SH-PTP3
Target Sequences: NM_002834 NP_002825.3 Q06124

Publications (2)

1
The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells. Zhan Y, Counelis GJ, O'Rourke DM. Experimental cell research. 2009 315:2343-57. (WB) [PubMed:19427850] [PMC:PMC2724964]
2
Src homology phosphotyrosyl phosphatase-2 expression is an independent negative prognostic factor in human breast cancer. Muenst S, Obermann EC, Gao F, Oertli D, Viehl CT, Weber WP, Fleming T, Gillanders WE, Soysal SD. Histopathology. 2013 Jul;63:74-82. [Full Text Article] [PubMed:23672411] [PMC:PMC4100721] Related Antibodies: LS-B542.

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Products
Antibodies (117)
Primary (117)
PTPN11 / SHP-2 / NS1 (117)
Human (115)
Mouse (84)
Rat (69)
Bat (2)
Bovine (13)
Chicken (15)
Chimpanzee (3)
Dog (15)
Gibbon (3)
Guinea pig (10)
Hamster (2)
Horse (15)
Monkey (12)
Pig (16)
Rabbit (12)
Sheep (3)
Xenopus (7)
Zebrafish (7)
IHC (60)
IHC-P (28)
WB (110)
Flo (11)
ELISA (35)
ICC (9)
IF (9)
IP (7)
Neut (1)
Peptide-ELISA (10)
rabbit (99)
mouse (17)
goat (1)
Product Group
IHCPlus (6)
IgG (68)
IgG1 (7)
IgG1,k (8)
IgG2a (2)
monoclonal mc (17)
polyclonal pc (100)
246CT9.8.2 (7)
6D9 (2)
OTI1F7 (2)
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AP Conjugated (4)
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Azide-free (2)
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Carrier-free (3)
FITC Conjugated (7)
HRP Conjugated (7)
Magnetic beads Conjugated (1)
PE Conjugated (4)
Sepharose Conjugated (1)
Unconjugated (83)
pTyr542 (9)
pTyr580 (9)
C-Terminus (5)
N-Terminus (5)
aa143-192 (4)
480-560 aa (2)
520-600 aa (2)
290-370 aa, Internal (1)
Amino Acid: 263-329 (1)
Glu574 (1)
Internal (1)
Lys536 (1)
Ser350 (1)
Tyr542 (1)
aa2-216 (1)
aa321-370 (1)
aa508-557 (1)
aa520-547 (1)
aa543-593 (1)
aa546-595 (1)
aa578-592 (1)
aa582-597 (1)
aa584-597 (1)
aa69-99 (1)
p542 (1)
p580 (1)
pSer576 (1)
No (116)
Yes (1)
PTPN11 / SHP-2 / NS1 Antibody - Anti-PTPN11 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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PTPN11 / SHP-2 / NS1 Goat anti-Human Polyclonal (aa584-597) Antibody
Xenopus, Chicken, Bovine, Bat, Rabbit, Horse, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$440
PTPN11 / SHP-2 / NS1 Antibody - IHC of paraffin-embedded breast cancer tissues using PTPN11 mouse monoclonal antibody with DAB staining.
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PTPN11 / SHP-2 / NS1 Mouse anti-Human Monoclonal (6D9) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
0.1 mg/$436
PTPN11 / SHP-2 / NS1 Antibody - Anti-PTPN11 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
PTPN11 / SHP-2 / NS1 Antibody - Immunohistochemical analysis of SHPTP2 (pY542) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (pTyr542) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$315
PTPN11 / SHP-2 / NS1 Antibody - Formalin-fixed and paraffin-embedded human skeletal muscle reacted with PTPN11 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa520-547) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$386
PTPN11 / SHP-2 / NS1 Antibody - Western blot of SH-PTP2 antibody
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (290-370 aa, Internal) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$293; 100 µg/$329; 200 µg/$400
PTPN11 / SHP-2 / NS1 Antibody - SHP2 Antibody in Immunohistochemistry (IHC)
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PTPN11 / SHP-2 / NS1 Mouse anti-Human Monoclonal (Amino Acid: 263-329) (6D9) Antibody
Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µg/$470
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (pTyr542) Antibody
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Horse, Human, Monkey
IHC, WB
Unconjugated
50 µg/$489
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
200 µl/$652
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$892
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (pTyr580) Antibody
Human
IP, WB
Unconjugated
100 µl/$637
PTPN11 / SHP-2 / NS1 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa321-370) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
PTPN11 / SHP-2 / NS1 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa508-557) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
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PTPN11 / SHP-2 / NS1 Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$361; 100 µl/$421; 200 µl/$481
PTPN11 / SHP-2 / NS1 Antibody - 1:100 staining mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PTPN11 / SHP-2 / NS1 Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (pTyr542) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PTPN11 / SHP-2 / NS1 Antibody - 1:200 staining human kidney tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (pTyr580) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
PTPN11 / SHP-2 / NS1 Antibody - Anti-PTPN11 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa143-192) Antibody
Chicken, Mouse, Dog, Guinea pig, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PTPN11 / SHP-2 / NS1 Antibody - Anti-PTPN11 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa143-192) (Biotin) Antibody
Chicken, Mouse, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
PTPN11 / SHP-2 / NS1 Antibody - Anti-PTPN11 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
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PTPN11 / SHP-2 / NS1 Rabbit anti-Mouse Polyclonal (aa2-216) Antibody
Mouse, Rat, Human
ICC, IP, Neut, WB
Unconjugated
200 µg/$821
PTPN11 / SHP-2 / NS1 Antibody - Immunohistochemistry of paraffin-embedded Human ovarian cancer using PTPN11 Polyclonal Antibody at dilution of 1:25.
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$463
PTPN11 / SHP-2 / NS1 Antibody
Select
PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$541
PTPN11 / SHP-2 / NS1 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SHP-2 Antibody. The picture on the right is blocked with the synthesized peptide.
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PTPN11 / SHP-2 / NS1 Rabbit anti-Human Polyclonal (aa546-595) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$328; 100 µl/$388
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).