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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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PTPN11 / SHP-2 / NS1

protein tyrosine phosphatase, non-receptor type 11

PTPN11 / SHP-2 / NS1 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: protein tyrosine phosphatase, non-receptor type 11
Family/Subfamily: Protein Phosphatase , NT2
Synonyms: PTPN11, Bptp-3, BPTP3, CFC, Csw, Corkscrew csw, Gene corkscrew, Phosphatase corkscrew, PTP-2C, SHP2, PTP-1D, PTP2C, SHP-2, SHPTP2, Noonan syndrome 1, SH-PTP2, SH-PTP3
Target Sequences: NM_002834 NP_002825.3 Q06124

Publications (2)

1
The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells. Zhan Y, Counelis GJ, O'Rourke DM. Experimental cell research. 2009 315:2343-57. (WB) [PubMed:19427850] [PMC:PMC2724964]
2
Src homology phosphotyrosyl phosphatase-2 expression is an independent negative prognostic factor in human breast cancer. Muenst S, Obermann EC, Gao F, Oertli D, Viehl CT, Weber WP, Fleming T, Gillanders WE, Soysal SD. Histopathology. 2013 Jul;63:74-82. [Full Text Article] [PubMed:23672411] [PMC:PMC4100721] Related Antibodies: LS-B542.

Viewing 1-25 of 121 items
PTPN11 / SHP-2 / NS1 Antibody - Anti-PTPN11 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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(1) Publication(s)
Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
PTPN11 / SHP-2 / NS1 Antibody - Anti-PTPN11 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Select
Goat Polyclonal to Human PTPN11 / SHP-2 / NS1
Xenopus, Chicken, Bovine, Bat, Rabbit, Horse, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
PTPN11 / SHP-2 / NS1 Antibody - Anti-PTPN11 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
PTPN11 / SHP-2 / NS1 Antibody - Anti-PTPN11 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.
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Rabbit Polyclonal to Human PTPN11 / SHP-2 / NS1
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   0.42mg/ml   $485.00
PTPN11 / SHP-2 / NS1 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl   1mg/ml   $505.00
PTPN11 / SHP-2 / NS1 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl   1mg/ml   $505.00
PTPN11 / SHP-2 / NS1 Antibody - Anti-PTPN11 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human PTPN11 / SHP-2 / NS1
Chicken, Mouse, Dog, Guinea pig, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
PTPN11 / SHP-2 / NS1 Antibody - Anti-PTPN11 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human PTPN11 / SHP-2 / NS1
Chicken, Mouse, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $385.00
PTPN11 / SHP-2 / NS1 Antibody - IHC of paraffin-embedded breast cancer tissues using PTPN11 mouse monoclonal antibody with DAB staining.
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Mouse Monoclonal [clone 6D9] (IgG1) to Human PTPN11 / SHP-2 / NS1
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100µg   1mg/ml   $365.00
PTPN11 / SHP-2 / NS1 Antibody - Immunohistochemical analysis of SHPTP2 (pY542) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human PTPN11 / SHP-2 / NS1
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $265.00
PTPN11 / SHP-2 / NS1 Antibody
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Mouse Monoclonal (IgG1,k) to Human PTPN11 / SHP-2 / NS1
Mouse, Rat, Human
IP, WB
Unconjugated
100µl   2mg/ml   $305.00
PTPN11 / SHP-2 / NS1 Antibody - Western blot of SH-PTP2 antibody
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Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
PTPN11 / SHP-2 / NS1 Antibody - Formalin-fixed and paraffin-embedded human skeletal muscle reacted with PTPN11 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human PTPN11 / SHP-2 / NS1
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
PTPN11 / SHP-2 / NS1 Antibody - SHP2 Antibody in Immunohistochemistry (IHC)
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Mouse Monoclonal [clone 6D9] (IgG1) to Human PTPN11 / SHP-2 / NS1
Human
Flo, ICC, IF, IHC, WB
Unconjugated
100µg   $405.00
Select
Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Horse, Human, Monkey
IHC, WB
Unconjugated
50µg   $435.00
Select
Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Human
IP, WB
Unconjugated
100µl   $575.00
Select
Mouse Monoclonal (IgG1) to Human PTPN11 / SHP-2 / NS1
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $375.00; 200µl   1mg/ml   $435.00
PTPN11 / SHP-2 / NS1 Antibody
Select
Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
PTPN11 / SHP-2 / NS1 Antibody
Select
Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
PTPN11 / SHP-2 / NS1 Antibody
Select
Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg   $335.00
Select
Rabbit Polyclonal (IgG) to Mouse PTPN11 / SHP-2 / NS1
Mouse, Rat, Human
ICC, IP, Neut, WB
Unconjugated
200µg   $710.00
PTPN11 / SHP-2 / NS1 Antibody - Immunohistochemistry of paraffin-embedded Human ovarian cancer using PTPN11 Polyclonal Antibody at dilution of 1:25.
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Rabbit Polyclonal (IgG) to Human PTPN11 / SHP-2 / NS1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl   0.3mg/ml   $205.00; 60µl   0.3mg/ml   $235.00; 120µl   0.3mg/ml   $295.00; 200µl   0.3mg/ml   $395.00

Viewing 1-25 of 121 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).