Human PLN / Phospholamban

Rabbit

Human, Mouse, Rat, Bat, Horse, Rabbit (tested or 100% immunogen sequence identity)

Bovine, Dog, Guinea pig, Pig, Sheep (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide from the N-Terminus of human Phospholamban (EKVQYLTRSAIRRAS, aa2-16 of UniProt P26678). Percent identity by BLAST analysis: Human, Mouse, Rat, Cat, Bat, Rabbit, Horse, Opossum (100%); Sheep, Bovine, Dolphin, Elephant, Pig, Guinea pig, Dog (93%); Turkey, Chicken, Platypus, Lizard (87%); Zebra finch, Zebrafish (80%).

aa2-16

Human PLN / Phospholamban

• Western blot (0.5 - 1 µg/ml)

Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca (2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. McTiernan et al. (1999) observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P26678 NCBI: NM_002667 NP_002658.1