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PLN / Phospholamban Antibody (phospho‑Ser16) LS‑C38229
Note: This antibody replaces LS-C86189
Phospholamban antibody LS-C38229 is an unconjugated rabbit polyclonal antibody to Phospholamban (PLN) from human and bovine. Validated for ELISA and WB.
Antibody
Catalog
Size
Price
LS-C38229-100
100 µg (1 mg/ml)
$740

Popular PLN / Phospholamban Products

Anti-PLN / Phospholamban antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Species: Dog, Human, Bovine, Pig
Applications: IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation
Anti-PLN / Phospholamban antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Antibody
Species: Human
Applications: IHC, Western blot, Flow Cytometry, ELISA
Antibody
Species: Human
Applications: ELISA, Dot Blot

Product Description

Phospholamban antibody LS-C38229 is an unconjugated rabbit polyclonal antibody to Phospholamban (PLN) from human and bovine. Validated for ELISA and WB.

Specifications

Target
Human PLN / Phospholamban
Synonyms
PLN, CMD1P, CMH18, PLB, Cardiac phospholamban, Phospholamban
Host
Rabbit
Reactivity
Human, Bovine (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (0.5 - 2 µg/ml)
  • ELISA
  • (applications tested for the base form of this product only)
Immunogen
Synthetic peptide corresponding to aa14-25 of human cardiac phospholamban with a cysteine added at the C-terminal (RA[pS]TIEMPQQAR-C) (KLH).
Epitope
pSer16
Specificity
Recognizes human Phospholamban phosphorylated (Ser16) (Mr 5-25kD). Species cross-reactivity: bovine. Species sequence Homology: mouse, rat, rabbit, porcine and canine.
Usage
Suitable for use in ELISA and Western Blot. Proteins were visualized using a goat anti-rabbit IgG labeled with HRP and a chemiluminescence detection system. Note: Do not boil cardiac preparation. Boiling may reduce the 25kD pentamer in to tri-, di- or monomers. In addition, phosphorylation may disrupt the pentamer into dimers and monomers. Additional non-specific bands may be detected in some lysates (Mr 75 & 100kD).
Presentation
0.1 M Tris-Glycine, pH 7.4, 0.15 M NaCl, 0.05% Sodium Azide, 30% Glycerol
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About PLN / Phospholamban
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. P26678 NM_002667 NP_002658.1


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Requested From: United States
Date Requested: 11/13/2018

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