Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner.
Gene Name: | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
Synonyms: | PIN1, DOD, PPIase Pin1, Rotamase Pin1 |
Target Sequences: | NM_006221 NP_006212.1 Q13526 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.