Bovine PIK3R1 / p85 Alpha
PIK3R1 | p85 | p85 Alpha | p85-ALPHA | PI3K regulatory subunit alpha | PI3-kinase subunit p85-alpha | GRB1
(tested or 100% immunogen sequence identity)
Balculovirus expressed (Recombinant) Bovine p85 alpha subunit of PI3 kinase.
Recognizes the SH3 domain of the p85 alpha subunit of bovine PI3 kinase, also known as Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kD regulatory subunit alpha or PtdIns-3-kinase regulatory subunit p85-alpha. p85 alpha PI3 kinase is a 724 amino acid ~85kD protein bearing a single domain, two domains and a single N-terminal domain. Multiple isoforms of the protein can be generated by alternative splicing,recognizes only those isoforms containing the SH3 domain (isoforms 1 and 4) but not those lacking the domain (isoforms 2,3 and 5). Deficiencies in the expression of the PIK3R1 gene can lead to immunodeficiency Agammaglobulinemia 7, autosomal recessive, due to the inhibition of B cell development and the developmental condition SHORT syndrome.