Human NQO1

Mouse

Human (tested or 100% immunogen sequence identity)

Mouse

IgG1 Monoclonal

A180

Unconjugated

Protein G purified

Unmodified

Purified recombinant human NQO1.

Recognizes human NQO1 (NAD(P)H: quinone oxidoreductase 1), a 31kD cytosolic flavoenzyme and member of the NAD(P)H dehydrogenase (quinone) family, involved in detoxification, which catalyzes the two-electron reduction of quinones to hydroquinones. NQO1 is expressed in a wide range of tissues and is overexpressed in many human tumors including lung, brain, liver, colon and breast. The ability of NQO1 to bioactivate anti-tumor quinones including mitomycin C and diaziquone, has become a focus area for chemotherapeutic studies. Mutations in the NQO1 gene are associated with an increased risk of certain cancers, and an increased risk of leukaemia has been associated with diminished NQO1 activity and the NQO1 *2 allele. Clone A180 detects endogenous levels of total NQO1, and does not cross-react with NQO2. Clone A180 is reported as suitable for use in immunofluorescence studies.

• IHC - Paraffin
• Western blot (1:100 - 1:1000)
• Immunoprecipitation

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P15559 NCBI: NM_000903 NP_000894.1