Human Ku70+Ku80 / XRCC6+XRCC5

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1,k Monoclonal

LKAP1-1

Unconjugated

Protein G purified

Azide-free, BSA-free. Also available Unmodified.

Human cell nuclear fraction.

Human Ku70+Ku80 / XRCC6+XRCC5

• Flow Cytometry (0.5 - 1 µg/10E6 cells)

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V (D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein. Titering of the Ku70 + Ku80 antibody may be required for optimal performance.

1X PBS

Store at 2°C to 8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.