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Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA3(Lys), the primer for reverse transcription initiation.
Gene Name: | lysyl-tRNA synthetase |
Synonyms: | KARS, CMTRIB, KARS1, KARS2, KRS, Lysine--tRNA ligase, LysRS, KIAA0070, Lysine tRNA ligase, Lysyl-tRNA synthetase |
Target Sequences: | NM_005548 NP_005539.1 Q15046 |
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