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IL10RA is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Gene Name: | interleukin 10 receptor, alpha |
Family/Subfamily: | Interleukin |
Synonyms: | IL10RA, CD210, CD210a, CD210 antigen, IBD28, IL-10R subunit 1, Il-10r, IL-10R subunit alpha, Interleukin 10 receptor, alpha, IL10R, Interleukin-10 receptor, HIL-10R, CDW210A, IL-10 receptor subunit alpha, IL-10R1, IL-10RA, Interleukin-10 receptors, IL-10 RA |
Target Sequences: | NM_001558 NP_001549.2 Q13651 |
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