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IFI16

interferon, gamma-inducible protein 16

Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Gene Name: interferon, gamma-inducible protein 16
Synonyms: IFI16, IFNGIP1, Ifi-16, PYHIN2
Target Sequences: NM_005531 NP_005522.2 Q16666

☰ Filters
Antibodies (33)
Proteins (6)
ELISA Kits (5)
Competitive EIA (1)
Over-Expression Lysate (2)
Primary (33)
Recombinant (4)
Sandwich (4)
IFI16 (44)
Human (36)
Mouse (2)
Rat (3)
IHC (6)
IHC-Fr (1)
IHC-P (3)
WB (33)
ELISA (7)
IF (4)
Peptide-ELISA (3)
rabbit (29)
mouse (4)
Product Group
IHCPlus (2)
IgG (13)
IgG2a,k (3)
IgG2b,k (1)
monoclonal mc (4)
polyclonal pc (29)
1B4 (1)
2E3 (1)
4E6 (1)
5C10 (1)
96-Well Microplate (1)
96-Well Strip Plate (4)
APC (1)
APC Conjugated (2)
Biotin Conjugated (3)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (2)
Unconjugated (18)
aa465-671 (8)
aa386-435 (4)
700-780 aa, C-terminal (1)
Asn772 (1)
aa723-772 (1)
aa731-780 (1)
No (44)
Plasma (5)
Serum (5)
Tissue Homogenates (1)
GST (1)
GST, N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
IFI16 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
IFI16 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
5 - 100 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
IFI16 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
IFI16 Mouse anti-Human Monoclonal (2E3) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
IFI16 Antibody - Immunoperoxidase of monoclonal antibody to IFI16 on formalin-fixed paraffin-embedded human prostate. [antibody concentration 0.5 ug/ml]
Select
IFI16 Mouse anti-Human Monoclonal (1B4) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
IFI16 Antibody - Immunofluorescence analysis of U2OS cell using IFI16 antibody. Blue: DAPI for nuclear staining.
Select
IFI16 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
IFI16 Antibody - IHC with IFI16 antibody on frozen human tonsil.
Select
IFI16 Mouse anti-Human Monoclonal (4E6) Antibody
Human
ELISA, IHC, IHC-Fr, WB
Unconjugated
50 µg/$460
Select
IFI16 Rabbit anti-Human Polyclonal (700-780 aa, C-terminal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
IFI16 Antibody - Immunoperoxidase of monoclonal antibody to IFI16 on formalin-fixed paraffin-embedded human prostate. [antibody concentration 1.2 ug/ml]
Select
IFI16 Mouse anti-Human Monoclonal (5C10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
IFI16 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
IFI16 Antibody - Immunohistochemistry of paraffin-embedded rat intestine using IFI16 Antibody at dilution of 1:100 (40x lens).
Select
IFI16 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
IFI16 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
Select
IFI16 Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
IFI16 Rabbit anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
IFI16 Antibody - The IFI16 Antibody is used in Western blot at 1:5000 dilution to detect purified recombinant human His-IFI16[6-102].
Select
IFI16 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$394
IFI16 Antibody - Western blot analysis of extracts from HeLa cells and HepG2 cells, using IFI16 antibody.
Select
IFI16 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
IFI16 Antibody - Western blot analysis of the lysates from HepG2 cells using IFI16 antibody.
Select
IFI16 Rabbit anti-Human Polyclonal (aa723-772) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
IFI16 Antibody - Western blot analysis of lysates from HeLa and HepG2 cells, using IFI16 Antibody. The lane on the right is blocked with the synthesized peptide.
Select
IFI16 Rabbit anti-Human Polyclonal (aa731-780) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
IFI16 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
Select
IFI16 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$937
Select
IFI16 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
Select
IFI16 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$937
Select
IFI16 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
Select
IFI16 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$386
IFI16 Antibody - IFI16 antibody Western Blot of Jurkat. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
IFI16 Rabbit anti-Human Polyclonal (aa386-435) Antibody
Human
WB
Unconjugated
100 µl/$424
IFI16 Antibody - Western blot of IFI-16 (N772) pAb in extracts from HepG2 cells.
Select
IFI16 Rabbit anti-Human Polyclonal (Asn772) Antibody
Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
IFI16 Antibody - Western blot of recombinant IFI16.
Select
IFI16 Rabbit anti-Human Polyclonal (aa465-671) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
Viewing 1-25 of 44 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).