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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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GDNF Antibody (aa78‑211) LS‑C343939
Note: This antibody replaces LS-C388534
GDNF antibody LS-C343939 is an unconjugated rabbit polyclonal antibody to GDNF from human and rat. Validated for WB.
Catalog
Size
Price
LS-C343939-100
100 µg (0.5 mg/ml)
$325
Description
GDNF antibody LS-C343939 is an unconjugated rabbit polyclonal antibody to GDNF from human and rat. Validated for WB.
Target
Human GDNF
Host
Rabbit
Reactivity
Human, Rat (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunogen affinity purified
Modifications
Unmodified
Applications
  • Western blot
Immunogen
GDNF antibody was raised against e.coli-derived human GDNF recombinant protein (Position: S78-I211). Human GDNF shares 93% amino acid (aa) sequence identity with both mouse and rat GDNF.
Epitope
aa78-211
Specificity
In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. .
Presentation
Contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2 HPO4, 0.05 mg sodium azide per 100 ug antibody.
Reconstitution
200 µl Distilled water
Storage
At -20°C for 1 year. After reconstitution, at 4°C for 1 month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid freeze-thaw cycles.
Restrictions
For research use only.
About GDNF
P39905 NM_000514 NP_000505.1

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Images

Western blot

GDNF antibody Western blot. All lanes: Anti-GDNF at 0.5 ug/ml. WB: Rat Brain Tissue Lysate at 40 ug. Predicted band size: 24 kD. Observed band size: 24 kD.
GDNF antibody Western blot. All lanes: Anti-GDNF at 0.5 ug/ml. WB: Rat Brain Tissue Lysate at 40 ug. Predicted band size: 24 kD. Observed band size: 24 kD.

Western blot

GDNF antibody Western blot. All lanes: Anti-GDNF at 0.5 ug/ml. WB: Rat Brain Tissue Lysate at 40 ug. Predicted band size: 24 kD. Observed band size: 24 kD.
GDNF antibody Western blot. All lanes: Anti-GDNF at 0.5 ug/ml. WB: Rat Brain Tissue Lysate at 40 ug. Predicted band size: 24 kD. Observed band size: 24 kD.

Western blot

GDNF antibody Western blot. All lanes: Anti-GDNF at 0.5 ug/ml. WB: Rat Brain Tissue Lysate at 40 ug. Predicted band size: 24 kD. Observed band size: 24 kD.
GDNF antibody Western blot. All lanes: Anti-GDNF at 0.5 ug/ml. WB: Rat Brain Tissue Lysate at 40 ug. Predicted band size: 24 kD. Observed band size: 24 kD.

Western blot

GDNF antibody Western blot. All lanes: Anti-GDNF at 0.5 ug/ml. WB: Rat Brain Tissue Lysate at 40 ug. Predicted band size: 24 kD. Observed band size: 24 kD.
GDNF antibody Western blot. All lanes: Anti-GDNF at 0.5 ug/ml. WB: Rat Brain Tissue Lysate at 40 ug. Predicted band size: 24 kD. Observed band size: 24 kD.

Requested From: United States
Date Requested: 11/18/2018
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