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Forkhead box C1 (FOXC1) belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of FOXC1 has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in FOXC1 cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.
Gene Name: | forkhead box C1 |
Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
Synonyms: | FOXC1, Forkhead-like 7, FREAC3, FKHL7, Forkhead-related activator 3, Forkhead-related protein FKHL7, IGDA, IHG1, IRID1, Forkhead box protein C1, Mesenchyme fork head protein 1, Myeloid factor-delta, ARA, Forkhead box C1, FREAC-3, RIEG3 |
Target Sequences: | NM_001453 NP_001444.2 Q12948 |
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