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EIF2B3 is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa |
Synonyms: | EIF2B3, EIF2Bgamma, EIF-2B |
Target Sequences: | NM_020365 NP_065098.1 Q9NR50 |
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