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Catalog Number Size Price
LS-C22805-50 50 µg $725 
Antibody

Monoclonal Mouse anti‑Human DSC1 / Desmocollin 1 Antibody (Intracellular, IHC, WB) LS‑C22805

Monoclonal Mouse anti‑Human DSC1 / Desmocollin 1 Antibody (Intracellular, IHC, WB) LS‑C22805

Antibody:
DSC1 / Desmocollin 1 Mouse anti-Human Monoclonal (Intracellular) Antibody
Application:
IHC, IHC-P, IHC-Fr, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$725
LS-C22805-50
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
DSC1 / Desmocollin 1 Mouse anti-Human Monoclonal (Intracellular) Antibody
Application:
IHC, IHC-P, IHC-Fr, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
Desmocollin 1 antibody LS-C22805 is an unconjugated mouse monoclonal antibody to human Desmocollin 1 (DSC1) (Intracellular). Validated for IHC and WB.
Target
Human DSC1 / Desmocollin 1
Synonyms
DSC1 | Desmocollin-1 | Desmocollin 1 | Desmosomal glycoprotein 2/3 | DG2/DG3 | Cadherin family member 1 | CDHF1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Immunogen
Synthetic peptide corresponding to sequence present within the intracellular part of human desmocollin 1 (HQTLESVKGVGQGDTGRYATDWQC). Percent identity by BLAST analysis: Human, Gibbon, Monkey (96%); Gorilla (92%); Marmoset (88%).
Epitope
Intracellular
Specificity
Antigen recognized in species specific for human. Cell Lines (tested so far) of differentiated cells. All simple epithelia are negative. desmocollin 1; negative with bovine (tested so far) and rodent material. Reacts with 111kD (form 'a') and 103kD (form 'b') polypeptides (desmocollin1 splice forms, both at pI 5.2) from human epidermal desmosomes. Reactivities on Cultured Positive on primary keratinocytes, however, restricted to local piles.
Applications
  • IHC
  • IHC - Paraffin
  • IHC - Frozen
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Suitable for use in Immunohistochemistry and Western Blot. Immunohistochemistry (Frozen, Paraffin, HEIR): 1:10 in PBS, pH 7.4; Incubation Time 1 hr at RT or overnight at 4?C. Note: For better resolution on frozen sections preincubation (directly after fixation) with 0.05-0.2% Triton X-100, for 5-10 min, depending on tissue type, is recommended (see ref. 2). Without detergent pretreatment a cytoplasmic component might cross-react (e. g. in fibroblasts). (Paraffin: slight cross-reactivity with a lymphocyte subpopulation is abolished by mild trypsinization after the microwave step. Localization: Localizes Dsc1 present in suprabasal layers of interfollicular epidermis; specific cell layers (e. g. in hair follicle root sheath); Hassall bodies (spheroidal formations of densely packed reticulum-derived cells in the thymus).
Presentation
Lyophilized PBS, pH 7.4, 0.09% Sodium Azide, 0.5% BSA
Reconstitution
Reconstitute with 1.0 ml sterile ddH2O
Storage
Lyophilized powder may be stored at -20°C. Stable for 1 year at -20°C. Aliquot and store at -20°C. Reconstituted product is stable for 1 year at -20°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About DSC1 / Desmocollin 1
Q08554 NM_024421 NP_077739.1

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 8/15/2022