CD2 | CD2 antigen | Erythrocyte receptor | LFA-3 receptor | LFA-2 | Lymphocyte-function antigen-2 | T11 | SRBC | CD2 molecule | Rosette receptor | T-cell surface antigen CD2
(tested or 100% immunogen sequence identity)
Equine peripheral blood lymphocytes.
Recognizes equine CD2, a 347 amino acid, single pass type-1 transmembrane glycoprotein containing single and domains. Equine CD2 is expressed by a large proportion of peripheral blood lymphocytes, most T-cells and few B-cells, it is not present on granulocytes. Immunohistochemical staining shows expression in most T cells of lymph node paracortex and occasional staining of lymphocytes in the follicular areas. In the thymus,stains the majority of mature thymocytes in the medulla and at least half of the immature thymocytes in the cortex. Recognizes CD2 in Haflinger and Lusitano horse breeds. Is a reliable pan T-cell marker for analysis of cell mediated immunity in horses infected with equine herpes virus by multi-parameter flow cytometry.