Human CBFA1 / RUNX2

Rabbit

Human, Chimpanzee, Orangutan, Gibbon, Monkey, Mouse, Rat, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Sheep (tested or 100% immunogen sequence identity)

Chicken (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

A synthetic peptide corresponding to a sequence in the middle region of human RUNX2(244-258 aa DRLSDLGRIPHPSMR). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Marmoset, Mouse, Ferret, Sheep, Hamster, Elephant, Rabbit, Horse, Pig, Guinea pig, Dog (100%); Turkey, Sparrow, Chicken, Platypus, Lizard (93%).

aa244-258

Human CBFA1 / RUNX2

• Western blot (0.5 - 1 µg/ml)

Core binding factor A1(CBFA1/RUNX2) is a runt-like transcription factor essential for osteoblast differentiation. This protein is a member of the RUNX family of transcription factors and has a Runt DNA-binding domain. It is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. D'Souza et al.(1999) indicate a non-redundant role for Cbfa1 in tooth development that may be distinct from that in bone formation. In odontogenesis, Cbfa1 is not involved in the early signaling networks regulating tooth initiation and early morphogenesis but regulates key epithelial-mesenchymal interactions that control advancing morphogenesis and histodifferentiation of the epithelial enamel organ.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q13950 NCBI: NM_004348 NP_004339.3