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CBFA1 / RUNX2
runt-related transcription factor 2
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
| Gene Name: | runt-related transcription factor 2 |
| Synonyms: | RUNX2, AML3, CCD, CCD1, OSF2, PEBP2A1, PEBP2A2, PEA2-alpha A, PEBP2-alpha A, OSF-2, PEBP2A, PEBP2aA1, CBF-alpha-1, CBFA1, Oncogene AML-3, PEA2aA, PEBP2aA |
| Target Sequences: | NM_004348 NP_004339.3 Q13950 |
Publications (2)
1
Hydrostatic pressure induces osteogenic differentiation of adipose-derived mesenchymal stem cells through increasing lncRNA-PAGBC. Jiangying Ru, Lieping Guo, Yinjun Ji, Yunfei Niu. Aging. 2020 July;12:13477-13487. [Full Text Article]
[PubMed:32661199]
[PMC:PMC7377829]
2
Tourniquet use following blast-associated complex lower limb injury and traumatic amputation promotes end organ dysfunction and amplified heterotopic ossification formation. Philip J Spreadborough, Amy L Strong, John Mares, Benjamin Levi, Thomas A Davis. Journal of orthopaedic surgery and research. 2022 September;17:422. [Full Text Article]
[PubMed:36123728]
[PMC:PMC9484189]
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CBFA1 / RUNX2
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Publications
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(92)
CBFA1 / RUNX2 Mouse anti-Human Monoclonal (1D8) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$485
CBFA1 / RUNX2 Mouse anti-Human Monoclonal (3F5) Antibody
Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CBFA1 / RUNX2 Mouse anti-Human Monoclonal (4D5) Antibody
Rat, Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µg/$460
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IHC, IHC-P
Unconjugated
0.1 ml/$386
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
ICC, IHC, IHC-P
Biotin Conjugated
0.1 ml/$416
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Human
ICC, IHC, IHC-P
DY650 Conjugated
0.1 ml/$416
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (Asp198) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (aa250-300) Antibody
Chicken, Bovine, Hamster, Pig, Horse, Bat, Mouse, Dog, Human, Monkey
WB
Unconjugated
100 µg/$386
CBFA1 / RUNX2 Mouse anti-Human Monoclonal (1D2) Antibody
Human
ELISA, IF, IHC-P, WB
Unconjugated
50 µg/$460
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (aa343-392) Antibody
Human
WB
Unconjugated
100 µl/$397
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (aa343-392) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$442
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (Ser533) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IHC, IHC-P
Unconjugated
0.1 ml/$460
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
ICC, IHC, IHC-P
Biotin Conjugated
0.1 ml/$416
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Human
ICC, IHC, IHC-P
DY650 Conjugated
0.1 ml/$416
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Human
ICC, IHC, IHC-P
DY488 Conjugated
0.1 ml/$416
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Human
ICC, IHC, IHC-P
DY550 Conjugated
0.1 ml/$416
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (aa229-278) Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$564
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$832
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
![CBFA1 / RUNX2 Antibody - Immunoperoxidase of monoclonal antibody to RUNX2 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/cbfa1-runx2-antibody-clone-6e1-ls-c133869/53209_5023779.jpg)
CBFA1 / RUNX2 Mouse anti-Human Monoclonal (6E1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CBFA1 / RUNX2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
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product results
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