Human AR / Androgen Receptor

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

Unconjugated

Unmodified

Synthetic peptide

• IHC - Paraffin (1:5 - 1:20)
• IHC - Frozen (1:5 - 1:20)

Heat pre-treatment of formalin-fixed tissue with antigen retrieval The antibody to androgen receptors binds to these proteins in nuclei of typical normal tissues. Over-expression may be observed in tumours like prostate carcinoma and osteosarcoma. For information transmission to the target cells male steroid hormones like Testosterone and DHT require a specific receptor. This specific receptor, called androgen receptor, is found in numerous human tissues like skin, mucous membranes, seminal vesicles, prostate gland and testis. Androgen receptors will also be found in human tumours like prostate carcinoma, osteosarcoma and others. In prostate carcinoma the clinical relevance has been proven by castration and androgen deprivation by Gn-RH-agonist and -antagonist treatment. In many cases androgen deprivation slows down tumour growth in androgen-dependent prostate carcinoma. Human androgen receptor, 110 kDa protein in lysate of LNCP cell line..

PBS, pH 7.3, 0.09% Sodium Azide

Store at 2°C to 8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P10275 NCBI: NM_000044 NP_000035.2